8IY5
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![BU of 8iy5 by Molmil](/molmil-images/mine/8iy5) | ETB-Gi complex bound to endothelin-1 | 分子名称: | Endothelin type B receptor, Endothelin-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Sano, F.K, Akasaka, H, Shihoya, W, Nureki, O. | 登録日 | 2023-04-04 | 公開日 | 2023-08-16 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structure of the endothelin-1-ET B -G i complex. Elife, 12, 2023
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6K7P
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![BU of 6k7p by Molmil](/molmil-images/mine/6k7p) | Crystal structure of human AFF4-THD domain | 分子名称: | AF4/FMR2 family member 4 | 著者 | Tang, D, Xue, Y, Li, S, Cheng, W, Duan, J, Wang, J, Qi, S. | 登録日 | 2019-06-08 | 公開日 | 2020-03-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription. Cell Discov, 6, 2020
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6H1I
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![BU of 6h1i by Molmil](/molmil-images/mine/6h1i) | Crystal structure of human Pirin in complex with bisamide compound 2 | 分子名称: | FE (III) ION, GLYCEROL, Pirin, ... | 著者 | Ali, S, Le Bihan, Y.V, van Montfort, R.L.M. | 登録日 | 2018-07-11 | 公開日 | 2018-11-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett, 9, 2018
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5E8I
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8JU6
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![BU of 8ju6 by Molmil](/molmil-images/mine/8ju6) | Structure of human TRPV4 with antagonist GSK279 | 分子名称: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-24 | 公開日 | 2024-05-08 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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8JU5
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![BU of 8ju5 by Molmil](/molmil-images/mine/8ju5) | Structure of human TRPV4 with antagonist A1 | 分子名称: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-24 | 公開日 | 2024-05-08 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.74 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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8JVI
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![BU of 8jvi by Molmil](/molmil-images/mine/8jvi) | Structure of human TRPV4 with antagonist A2 | 分子名称: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 最終更新日 | 2024-07-24 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
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6E49
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![BU of 6e49 by Molmil](/molmil-images/mine/6e49) | Pif1 peptide bound to PCNA trimer | 分子名称: | ATP-dependent DNA helicase PIF1, Proliferating cell nuclear antigen | 著者 | Buzovetsky, O, Kwon, Y, Pham, N.T, Kim, C, Ira, G, Sung, P, Xiong, Y. | 登録日 | 2018-07-17 | 公開日 | 2018-08-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Role of the Pif1-PCNA Complex in Pol delta-Dependent Strand Displacement DNA Synthesis and Break-Induced Replication. Cell Rep, 21, 2017
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3I4B
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![BU of 3i4b by Molmil](/molmil-images/mine/3i4b) | Crystal structure of GSK3b in complex with a pyrimidylpyrrole inhibitor | 分子名称: | Glycogen synthase kinase-3 beta, N-[(1S)-2-hydroxy-1-phenylethyl]-4-[5-methyl-2-(phenylamino)pyrimidin-4-yl]-1H-pyrrole-2-carboxamide | 著者 | Ter Haar, E. | 登録日 | 2009-07-01 | 公開日 | 2010-01-12 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control. J.Med.Chem., 52, 2009
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8J1N
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![BU of 8j1n by Molmil](/molmil-images/mine/8j1n) | Structure of human UCP1 in the DNP-bound state | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ... | 著者 | Chen, L, Kang, Y. | 登録日 | 2023-04-13 | 公開日 | 2023-06-21 | 最終更新日 | 2023-08-30 | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | 主引用文献 | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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5G49
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![BU of 5g49 by Molmil](/molmil-images/mine/5g49) | Crystal structure of the Arabodopsis thaliana histone-fold dimer L1L NF-YC3 | 分子名称: | ACETATE ION, CALCIUM ION, NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT B-6, ... | 著者 | Gnesutta, N, Saad, D, Chaves-Sanjuan, A, Mantovani, R, Nardini, M. | 登録日 | 2016-05-06 | 公開日 | 2016-12-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure of the Arabidopsis thaliana L1L/NF-YC3 Histone-fold Dimer Reveals Specificities of the LEC1 Family of NF-Y Subunits in Plants. Mol Plant, 10, 2017
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2KKW
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![BU of 2kkw by Molmil](/molmil-images/mine/2kkw) | SLAS-micelle bound alpha-synuclein | 分子名称: | Alpha-synuclein | 著者 | Rao, J, Jao, C.C, Hegde, B, Langen, R, Ulmer, T.S. | 登録日 | 2009-06-29 | 公開日 | 2010-06-16 | 最終更新日 | 2024-05-01 | 実験手法 | EPR, SOLUTION NMR | 主引用文献 | A combinatorial NMR and EPR approach for evaluating the structural ensemble of partially folded proteins. J.Am.Chem.Soc., 132, 2010
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6GHK
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![BU of 6ghk by Molmil](/molmil-images/mine/6ghk) | Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527 | 分子名称: | Poly [ADP-ribose] polymerase 1, SULFATE ION, ~{N}-[(1~{R})-1-(4-imidazol-1-ylphenyl)ethyl]-3-(4-oxidanylidene-1~{H}-quinazolin-2-yl)propanamide | 著者 | Karlberg, T, Thorsell, A.G, Lindgren, A.E.G, Moche, M, Brock, J, Ekblad, T, Spjut, S, Elofsson, M, Schuler, H. | 登録日 | 2018-05-08 | 公開日 | 2019-05-22 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527 To Be Published
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5GW9
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6K5W
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2VRR
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![BU of 2vrr by Molmil](/molmil-images/mine/2vrr) | Structure of SUMO modified Ubc9 | 分子名称: | FORMIC ACID, SMALL UBIQUITIN-RELATED MODIFIER 1, SODIUM ION, ... | 著者 | Knipscheer, P, Flotho, A, Klug, H, Olsen, J.V, van Dijk, W.J, Fish, A, Johnson, E.S, Mann, M, Sixma, T.K, Pichler, A. | 登録日 | 2008-04-13 | 公開日 | 2008-08-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Ubc9 sumoylation regulates SUMO target discrimination. Mol. Cell, 31, 2008
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5H6Y
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8JRN
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![BU of 8jrn by Molmil](/molmil-images/mine/8jrn) | Structure of E6AP-E6 complex in Att1 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRQ
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![BU of 8jrq by Molmil](/molmil-images/mine/8jrq) | Structure of E6AP-E6 complex in Det1 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRP
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![BU of 8jrp by Molmil](/molmil-images/mine/8jrp) | Structure of E6AP-E6 complex in Att3 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRR
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![BU of 8jrr by Molmil](/molmil-images/mine/8jrr) | Structure of E6AP-E6 complex in Det2 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.35 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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8JRO
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![BU of 8jro by Molmil](/molmil-images/mine/8jro) | Structure of E6AP-E6 complex in Att2 state | 分子名称: | Protein E6, Ubiquitin-protein ligase E3A, ZINC ION | 著者 | Wang, Z, Yu, X. | 登録日 | 2023-06-17 | 公開日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.01 Å) | 主引用文献 | Structural insights into the functional mechanism of the ubiquitin ligase E6AP. Nat Commun, 15, 2024
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6HRQ
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![BU of 6hrq by Molmil](/molmil-images/mine/6hrq) | Crystal structure of Schistosoma mansoni HDAC8 complexed with NCC-149 | 分子名称: | DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... | 著者 | Shaik, T.B, Marek, M, Romier, C. | 登録日 | 2018-09-28 | 公開日 | 2018-10-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.845 Å) | 主引用文献 | Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
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6HTI
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![BU of 6hti by Molmil](/molmil-images/mine/6hti) | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 6 | 分子名称: | GLYCEROL, Histone deacetylase, POTASSIUM ION, ... | 著者 | Shaik, T.B, Marek, M, Romier, C. | 登録日 | 2018-10-04 | 公開日 | 2018-10-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.693 Å) | 主引用文献 | Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
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6HTT
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![BU of 6htt by Molmil](/molmil-images/mine/6htt) | Crystal structure of Schistosoma mansoni HDAC8 complexed with a benzohydroxamate inhibitor 7 | 分子名称: | DIMETHYLFORMAMIDE, GLYCEROL, Histone deacetylase, ... | 著者 | Shaik, T.B, Marek, M, Romier, C. | 登録日 | 2018-10-04 | 公開日 | 2018-10-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.748 Å) | 主引用文献 | Characterization of Histone Deacetylase 8 (HDAC8) Selective Inhibition Reveals Specific Active Site Structural and Functional Determinants. J. Med. Chem., 61, 2018
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