5E8I

Crystal structure of the DNA binding domain of human transcription factor FLI1 in complex with a 10-mer DNA ACCGGAAGTG

Summary for 5E8I

• Entry DOI: 10.2210/pdb5e8i/pdb
• Related: 5E8G
• Descriptor: Friend leukemia integration 1 transcription factor, DNA (5'-D(*AP*CP*CP*GP*GP*AP*AP*GP*TP*G)-3'), DNA (5'-D(*CP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), ... (5 entities in total)
• Functional Keywords: transcription, dna binding, ewing sarcoma, winged helix, ets family, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: Q01543
• Total number of polymer chains: 12
• Total formula weight: 84467.98

Authors

Hou, C.,Tsodikov, O.V. (deposition date: 2015-10-14, release date: 2015-12-09, Last modification date: 2023-09-27)

• Primary citation: Hou, C.,Tsodikov, O.V.; Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1.; Biochemistry, 54:7365-7374, 2015; PubMed: 26618620; DOI: 10.1021/acs.biochem.5b01121

Experimental method

X-RAY DIFFRACTION (3.45 Å)