6H1I

Crystal structure of human Pirin in complex with bisamide compound 2

Summary for 6H1I

Entry DOI	10.2210/pdb6h1i/pdb
Descriptor	Pirin, FE (III) ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	transcriptional coregulator, quercetin 2, 3-dioxygenase, inhibitor, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33227.28
Authors	Ali, S.,Le Bihan, Y.V.,van Montfort, R.L.M. (deposition date: 2018-07-11, release date: 2018-11-28, Last modification date: 2024-01-17)
Primary citation	Meyers, J.,Chessum, N.E.A.,Ali, S.,Mok, N.Y.,Wilding, B.,Pasqua, A.E.,Rowlands, M.,Tucker, M.J.,Evans, L.E.,Rye, C.S.,O'Fee, L.,Le Bihan, Y.V.,Burke, R.,Carter, M.,Workman, P.,Blagg, J.,Brown, N.,van Montfort, R.L.M.,Jones, K.,Cheeseman, M.D. Privileged Structures and Polypharmacology within and between Protein Families. ACS Med Chem Lett, 9:1199-1204, 2018 Cited by PubMed: 30613326 DOI: 10.1021/acsmedchemlett.8b00364 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.69 Å)

Structure validation