8ZCJ
| Cryo-EM structure of the pasireotide-bound SSTR5-Gi complex | 分子名称: | 004-DTR-LYS-TYR-PHA-HYP, Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-29 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
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6DGT
| Selective PI3K beta inhibitor bound to PI3K delta | 分子名称: | 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 著者 | Somoza, J, Villasenor, A, McGrath, M. | 登録日 | 2018-05-18 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) beta Inhibitor. J. Med. Chem., 61, 2018
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7ZC9
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7YNT
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9AVU
| Bovine fetal muscle nAChR bound to ACh | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, ... | 著者 | Li, H, Hibbs, R.E. | 登録日 | 2024-03-05 | 公開日 | 2024-07-31 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Structural switch in acetylcholine receptors in developing muscle. Nature, 632, 2024
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7ZCB
| Human Pikachurin/EGFLAM N-terminal Fibronectin-III (1-2) domains | 分子名称: | CHLORIDE ION, Pikachurin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Pantalone, S, Savino, S, Viti, L.V, Forneris, F. | 登録日 | 2022-03-26 | 公開日 | 2023-07-19 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179. Sci.Signal., 16, 2023
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9AVV
| Bovine adult muscle nAChR resting state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ... | 著者 | Li, H, Hibbs, R.E. | 登録日 | 2024-03-05 | 公開日 | 2024-07-31 | 最終更新日 | 2024-09-18 | 実験手法 | ELECTRON MICROSCOPY (2.09 Å) | 主引用文献 | Structural switch in acetylcholine receptors in developing muscle. Nature, 632, 2024
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8WWF
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1E9Q
| Crystal structure of bovine Cu Zn SOD - (1 of 3) | 分子名称: | COPPER (II) ION, SUPEROXIDE DISMUTASE, ZINC ION | 著者 | Hough, M.A, Hasnain, S.S. | 登録日 | 2000-10-26 | 公開日 | 2000-12-03 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Conformational Variability of the Cu Site in One Subunit of Bovine Cuzn Superoxide Dismutase: The Importance of Mobility in the Glu119-Leu142 Loop Region for Catalytic Function J.Mol.Biol., 304, 2000
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8XB7
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7YUZ
| Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP8784 | 分子名称: | AP8784, GUANOSINE-5'-DIPHOSPHATE, IODIDE ION, ... | 著者 | Irie, M, Fukami, T.A, Tanada, M, Ohta, A, Torizawa, T. | 登録日 | 2022-08-18 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.878 Å) | 主引用文献 | Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets. J.Am.Chem.Soc., 145, 2023
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8XXL
| Cryo-EM structure of the human 40S ribosome with PDCD4 | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Ye, X, Huang, Z, Li, Y, Wang, M, Cheng, J. | 登録日 | 2024-01-18 | 公開日 | 2024-05-01 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation. Cell Res., 34, 2024
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9C57
| Reconstituted P400 Subcomplex of the human TIP60 complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Actin, cytoplasmic 1, ... | 著者 | Yang, Z, Mameri, A, Florez Ariza, A.J, Cote, J, Nogales, E. | 登録日 | 2024-06-05 | 公開日 | 2024-08-21 | 最終更新日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Structural insights into the human NuA4/TIP60 acetyltransferase and chromatin remodeling complex. Science, 385, 2024
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9BF0
| MID domain of human Argo2 bound to UTP | 分子名称: | Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE | 著者 | Harp, J.M, Egli, M. | 登録日 | 2024-04-16 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth. Curr Protoc, 4, 2024
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8YKW
| Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid | 分子名称: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | 登録日 | 2024-03-05 | 公開日 | 2024-05-29 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | 主引用文献 | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1. Cell Res., 34, 2024
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9FBW
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7YNM
| ThT-bound alpha-synuclein fibrils conformation 1 | 分子名称: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, Alpha-synuclein | 著者 | Tao, Y.Q, Zhao, Q.Y, Liu, C, Li, D. | 登録日 | 2022-07-31 | 公開日 | 2023-08-02 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | ThT-bound alpha-synuclein fibrils conformation 1 To Be Published
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8WWE
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7YV1
| Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor LUNA18 and KA30L Fab | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, KA30L Fab H-chain, ... | 著者 | Irie, M, Fukami, T.A, Matsuo, A, Saka, K, Nishimura, M, Saito, H, Torizawa, T, Tanada, M, Ohta, A. | 登録日 | 2022-08-18 | 公開日 | 2023-07-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.454 Å) | 主引用文献 | Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets. J.Am.Chem.Soc., 145, 2023
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9F0E
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7YN3
| Crystal structure of CcbD complex with CcbZ carrier protein domain | 分子名称: | 1,1'-ethane-1,2-diyldipyrrolidine-2,5-dione, 4'-PHOSPHOPANTETHEINE, CcbD, ... | 著者 | Mori, T, Lyu, S, Abe, I. | 登録日 | 2022-07-29 | 公開日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of CcbD complex with carrier protein To Be Published
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7YNQ
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8ZBE
| cryo-EM structure of the octreotide-bound SSTR5-Gi complex | 分子名称: | Beta-2 adrenergic receptor,Somatostatin receptor type 5,lgbit (fusion protein), Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Li, Y.G, Meng, X.Y, Yang, X.R, Ling, S.L, Shi, P, Tian, C.L, Yang, F. | 登録日 | 2024-04-26 | 公開日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Structural insights into somatostatin receptor 5 bound with cyclic peptides. Acta Pharmacol.Sin., 2024
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9AWJ
| Bovine adult muscle nAChR bound to ACh | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINE, ... | 著者 | Li, H, Hibbs, R.E. | 登録日 | 2024-03-05 | 公開日 | 2024-07-31 | 最終更新日 | 2024-09-18 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Structural switch in acetylcholine receptors in developing muscle. Nature, 632, 2024
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7YLQ
| Crystal structure of Microcystinase C from Sphingomonas sp. ACM-3962 at 2.6 A resolution | 分子名称: | CALCIUM ION, Microcystinase C, ZINC ION | 著者 | Guo, X, Li, Z, Ding, W, Yin, P, Feng, L. | 登録日 | 2022-07-26 | 公開日 | 2023-08-09 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Crystal structure of Microcystin C from Sphingomonas sp. ACM-3962 at 2.6 A resolution To Be Published
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