7YUZ

Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP8784

Summary for 7YUZ

• Entry DOI: 10.2210/pdb7yuz/pdb
• Descriptor: Isoform 2B of GTPase KRas, AP8784, GUANOSINE-5'-DIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: oncology, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 22180.53

Authors

Irie, M.,Fukami, T.A.,Tanada, M.,Ohta, A.,Torizawa, T. (deposition date: 2022-08-18, release date: 2023-07-26, Last modification date: 2023-11-22)

• Primary citation: Ohta, A.,Tanada, M.,Shinohara, S.,Morita, Y.,Nakano, K.,Yamagishi, Y.,Takano, R.,Kariyuki, S.,Iida, T.,Matsuo, A.,Ozeki, K.,Emura, T.,Sakurai, Y.,Takano, K.,Higashida, A.,Kojima, M.,Muraoka, T.,Takeyama, R.,Kato, T.,Kimura, K.,Ogawa, K.,Ohara, K.,Tanaka, S.,Kikuchi, Y.,Hisada, N.,Hayashi, R.,Nishimura, Y.,Nomura, K.,Tachibana, T.,Irie, M.,Kawada, H.,Torizawa, T.,Murao, N.,Kotake, T.,Tanaka, M.,Ishikawa, S.,Miyake, T.,Tamiya, M.,Arai, M.,Chiyoda, A.,Akai, S.,Sase, H.,Kuramoto, S.,Ito, T.,Shiraishi, T.,Kojima, T.,Iikura, H.; Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.; J.Am.Chem.Soc., 145:24035-24051, 2023; PubMed: 37874670; DOI: 10.1021/jacs.3c07145

Experimental method

X-RAY DIFFRACTION (1.878 Å)