7YUZ
Human K-Ras G12D (GDP-bound) in complex with cyclic peptide inhibitor AP8784
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Isoform 2B of GTPase KRas | polymer | 179 | 20150.6 | 1 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (human) | |
| 2 | B (I) | AP8784 | polymer | 11 | 1435.5 | 1 | synthetic construct | ||
| 3 | C (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 5 | E (A) | IODIDE ION | non-polymer | 126.9 | 1 | Chemie (IOD) PubChem (30165) | |||
| 6 | F (A) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A: 2 - 174 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Ser 1 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21586.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 594.4 | |
| All* | Total formula weight | 22180.5 |
