PDB: 1845 件ウェブページステータス検索Chemie searchBIRD

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4OED	Crystal structure of AR-LBD bound with co-regulator peptide 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Protein BUD31 homolog, ... 著者 Liu, J.S, Hsu, C.L, Wu, W.G. 登録日 2014-01-13 公開日 2014-08-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OEA	Crystal structure of AR-LBD 分子名称: 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor 著者 Liu, J.S, Hsu, C.L, Wu, W.G. 登録日 2014-01-12 公開日 2014-08-20 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 Identification of a new androgen receptor (AR) co-regulator BUD31 and related peptides to suppress wild-type and mutated AR-mediated prostate cancer growth via peptide screening and X-ray structure analysis. Mol Oncol, 8, 2014
4OC7	Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2 分子名称: (2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Leysen, S, Scheepstra, M, Brunsveld, L, Milroy, L.G, Ottmann, C. 登録日 2014-01-08 公開日 2014-10-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A natural-product switch for a dynamic protein interface. Angew.Chem.Int.Ed.Engl., 53, 2014
4OAR	Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT 分子名称: Peptide from Nuclear receptor corepressor 2, Progesterone receptor, [(8S,11R,13S,14S,17R)-17-acetyl-11-[4-(dimethylamino)phenyl]-13-methyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopen ta[a]phenanthren-17-yl] acetate 著者 Petit-Topin, I, Fay, M.R, Resche-Rigon, M, Ulmann, A, Gainer, E, Rafestin-Oblin, M.-E, Fagart, J. 登録日 2014-01-06 公開日 2014-10-08 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors. J.Steroid Biochem.Mol.Biol., 144PB, 2014
4O8F	Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone 分子名称: 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), Peroxisome proliferator-activated receptor gamma 著者 Pochetti, G, Montanari, R, Capelli, D, Chiaraluce, R, Consalvi, V, Lori, C, Loiodice, F, Laghezza, A, Pasquo, A, Cervoni, L, Aschi, M. 登録日 2013-12-27 公開日 2014-07-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy. Acta Crystallogr.,Sect.D, 70, 2014
4NY9	Crystal Structure Of the Human PXR-LBD In Complex With N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide 分子名称: GLYCEROL, N-{(2R)-1-[(4S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl}-3-hydroxy-3-methylbutanamide, Nuclear receptor subfamily 1 group I member 2 著者 Khan, J.A, Camac, D.M. 登録日 2013-12-10 公開日 2014-08-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. J.Med.Chem., 57, 2014
4NUF	Crystal Structure of SHP/EID1 分子名称: EID1 peptide, Maltose ABC transporter periplasmic protein, Nuclear receptor subfamily 0 group B member 2 chimeric construct, ... 著者 Zhi, X, Zhou, X.E, He, Y, Zechner, C, Suino-Powell, K.M, Kliewer, S.A, Melcher, K, Mangelsdorf, D.J, Xu, H.E. 登録日 2013-12-03 公開日 2014-01-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structural insights into gene repression by the orphan nuclear receptor SHP. Proc.Natl.Acad.Sci.USA, 111, 2014
4NQA	Crystal structure of liganded hRXR-alpha/hLXR-beta heterodimer on DNA 分子名称: (9cis)-retinoic acid, 5'-D(*TP*AP*AP*GP*GP*TP*CP*AP*CP*TP*TP*CP*AP*GP*GP*TP*CP*A)-3', 5'-D(*TP*AP*TP*GP*AP*CP*CP*TP*GP*AP*AP*GP*TP*GP*AP*CP*CP*T)-3', ... 著者 Lou, X.H, Toresson, G, Benod, C, Suh, J.H, Phillips, K.J, Webb, P, Gustafsson, J.A. 登録日 2013-11-24 公開日 2014-02-26 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.102 Å) 主引用文献 Structure of the retinoid X receptor alpha-liver X receptor beta (RXR alpha-LXR beta ) heterodimer on DNA. Nat.Struct.Mol.Biol., 21, 2014
4NIE	Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand 分子名称: 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... 著者 Ma, Y.L, Yang, L.Q. 登録日 2013-11-06 公開日 2013-12-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 5, 2014
4NB6	Crystal structure of the ligand binding domain of RORC with T0901317 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear receptor ROR-gamma 著者 Hymowitz, S.G, Boenig-de Leon, G. 登録日 2013-10-22 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg.Med.Chem.Lett., 23, 2013
4N8R	Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 分子名称: 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-17 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
4N73	Crystal structure of the ligand binding domain (LBD) of REV-ERB beta bound to Cobalt Protoporphyrin IX 分子名称: Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING CO 著者 Matta-Camacho, E, Kojetin, D. 登録日 2013-10-14 公開日 2014-06-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8662 Å) 主引用文献 Structure of REV-ERB beta Ligand-binding Domain Bound to a Porphyrin Antagonist. J.Biol.Chem., 289, 2014
4N5G	Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 分子名称: 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha 著者 Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. 登録日 2013-10-09 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
4N1Y	Crystal Structure of the Pacific Oyster Estrogen Receptor Ligand Binding Domain 分子名称: Estrogen receptor 著者 Ortlund, E.O. 登録日 2013-10-04 公開日 2014-02-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.605 Å) 主引用文献 Vestigialization of an allosteric switch: genetic and structural mechanisms for the evolution of constitutive activity in a steroid hormone receptor. PLoS Genet, 10, 2014
4MGD	Crystal structure of hERa-LBD (Y537S) in complex with HPTE 分子名称: 1,2-ETHANEDIOL, 4,4'-(2,2,2-trichloroethane-1,1-diyl)diphenol, Estrogen receptor, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGC	Crystal structure of hERa-LBD (Y537S) in complex with benzophenone-2 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGB	Crystal structure of hERa-LBD (Y537S) in complex with TCBPA 分子名称: 4,4'-propane-2,2-diylbis(2,6-dichlorophenol), Estrogen receptor, GLYCEROL, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MGA	Crystal structure of hERa-LBD (Y537S) in complex with 4-tert-octylphenol 分子名称: 4-(2,4,4-trimethylpentan-2-yl)phenol, Estrogen receptor, Nuclear receptor coactivator 1 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG9	Crystal structure of hERa-LBD (Y537S) in complex with butylparaben 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG8	Crystal structure of hERa-LBD (Y537S) in complex with alpha-zearalanol 分子名称: 1,2-ETHANEDIOL, Estrogen receptor, GLYCEROL, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG7	Crystal structure of hERa-LBD (Y537S) in complex with ferutinine 分子名称: 1,2-ETHANEDIOL, Estrogen receptor, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG6	Crystal structure of hERa-LBD (Y537S) in complex with benzylbutylphtalate 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MG5	Crystal structure of hERa-LBD (Y537S) in complex with chlordecone 分子名称: Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... 著者 Delfosse, V, Grimaldi, M, Bourguet, W. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
4MDD	Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 分子名称: Glucocorticoid receptor, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, Nuclear receptor corepressor 1 著者 Coghlan, M.J, Luz, J.G. 登録日 2013-08-22 公開日 2014-12-03 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12 To be Published
4M8H	CRYSTAL STRUCTURE OF HUMAN RETINOID X RECEPTOR ALPHA-LIGAND BINDING DOMAIN COMPLEX WITH (R)4-METHYL 9cUAB30 AND COACTIVATOR PEPTIDE GRIP-1 分子名称: (2E,6Z,8E)-3,7-dimethyl-8-[(4R)-4-methyl-3,4-dihydronaphthalen-1(2H)-ylidene]octa-2,6-dienoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2013-08-13 公開日 2014-01-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorg.Med.Chem., 22, 2014

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