Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone

Summary for 4O8F

Related4L98 4L96 2PRG 3B3K
DescriptorPeroxisome proliferator-activated receptor gamma, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL) (3 entities in total)
Functional Keywordsbundle of alpha-helices, small four-stranded beta-sheet, transcription factor, rxralpha, transcription-transcription inhibitor complex, transcription/transcription inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight65930.27
Pochetti, G.,Montanari, R.,Capelli, D.,Chiaraluce, R.,Consalvi, V.,Lori, C.,Loiodice, F.,Laghezza, A.,Pasquo, A.,Cervoni, L.,Aschi, M. (deposition date: 2013-12-27, release date: 2014-07-23, Last modification date: 2019-07-17)
Primary citation
Lori, C.,Pasquo, A.,Montanari, R.,Capelli, D.,Consalvi, V.,Chiaraluce, R.,Cervoni, L.,Loiodice, F.,Laghezza, A.,Aschi, M.,Giorgi, A.,Pochetti, G.
Structural basis of the transactivation deficiency of the human PPAR gamma F360L mutant associated with familial partial lipodystrophy.
Acta Crystallogr.,Sect.D, 70:1965-1976, 2014
PubMed: 25004973 (PDB entries with the same primary citation)
DOI: 10.1107/S1399004714009638
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.29117 2.3% 3.8% 4.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report