4OC7
Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2
Summary for 4OC7
Entry DOI | 10.2210/pdb4oc7/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid, ... (4 entities in total) |
Functional Keywords | ligand binding domain, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus : P19793 Q15596 |
Total number of polymer chains | 2 |
Total formula weight | 30132.72 |
Authors | Leysen, S.,Scheepstra, M.,Brunsveld, L.,Milroy, L.G.,Ottmann, C. (deposition date: 2014-01-08, release date: 2014-10-08, Last modification date: 2024-02-28) |
Primary citation | Scheepstra, M.,Nieto, L.,Hirsch, A.K.,Fuchs, S.,Leysen, S.,Lam, C.V.,in het Panhuis, L.,van Boeckel, C.A.,Wienk, H.,Boelens, R.,Ottmann, C.,Milroy, L.G.,Brunsveld, L. A natural-product switch for a dynamic protein interface. Angew.Chem.Int.Ed.Engl., 53:6443-6448, 2014 Cited by PubMed: 24821627DOI: 10.1002/anie.201403773 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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