4OC7

Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Retinoic acid receptor RXR-alpha	polymer	254	28272.5	1	UniProt (P19793) Pfam (PF00104) In PDB	Homo sapiens (human)	Nuclear receptor subfamily 2 group B member 1, Retinoid X receptor alpha
2	B	Nuclear receptor coactivator 2	polymer	13	1579.9	1	UniProt (Q15596) In PDB	Homo sapiens	NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2
3	A	(2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid	non-polymer		280.3	1	Chemie (2QO)
4		water	water		18.0	6	Chemie (HOH)

Sequence modifications

A: 223 - 462 (UniProt: P19793)

PDB	External Database	Details
Gly 209	-	expression tag
Ser 210	-	expression tag
His 211	-	expression tag
Met 212	-	expression tag
Thr 213	-	expression tag
Ser 214	-	expression tag
Ser 215	-	expression tag
Ala 216	-	expression tag
Asn 217	-	expression tag
Glu 218	-	expression tag
Gly 219	-	expression tag
Ser 220	-	expression tag
His 221	-	expression tag
Met 222	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	29852.4
Non-Polymers*	Number of molecules	1
	Total formula weight	280.3
All*	Total formula weight	30132.7

*Water molecules are not included.