PDB: 1342 件ウェブページステータス検索Chemie searchBIRD

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7R0Q	KRasG12C in complex with GDP and compound 3 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Ostermann, N. 登録日 2022-02-02 公開日 2022-04-27 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov, 12, 2022
7R0M	KRasG12C in complex with GDP and JDQ443 分子名称: 1-[6-[4-(5-chloranyl-6-methyl-1~{H}-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ostermann, N. 登録日 2022-02-02 公開日 2022-04-27 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.611 Å) 主引用文献 Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov, 12, 2022
7U2P	Structure of TcdA GTD in complex with RhoA 分子名称: GUANOSINE-5'-DIPHOSPHATE, Glucosyltransferase TcdA, MAGNESIUM ION, ... 著者 Baohua, C, Zheng, L, Kay, P, Rongsheng, J. 登録日 2022-02-24 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.596 Å) 主引用文献 Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition. Sci Rep, 12, 2022
7TVF	Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom 分子名称: CHLORIDE ION, GLYCEROL, Leucine-rich repeat protein SHOC-2, ... 著者 Bonsor, D.A, Simanshu, D.K. 登録日 2022-02-04 公開日 2022-05-04 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Nat.Struct.Mol.Biol., 29, 2022
7UPI	Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex 分子名称: CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... 著者 Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. 登録日 2022-04-15 公開日 2022-05-04 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.89 Å) 主引用文献 Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
7MQU	The haddock model of GDP KRas in complex with promethazine using NMR chemical shift perturbations 分子名称: (2R)-N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Wang, X, Gorfe, A.A, Putkey, J.P. 登録日 2021-05-06 公開日 2022-05-11 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Antipsychotic phenothiazine drugs bind to KRAS in vitro. J.Biomol.Nmr, 75, 2021
7VV9	Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-05 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VVG	Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-06 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VV8	Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-04 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VVB	Crystal Structure of KRas4A(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-05 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7SCW	KRAS full length wild-type in complex with RGL1 Ras association domain 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... 著者 Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. 登録日 2021-09-29 公開日 2022-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
7SCX	KRAS full-length G12V in complex with RGL1 Ras association domain 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION, ... 著者 Eves, B.J, Kuntz, D.A, Ikura, M, Marshall, C.B. 登録日 2021-09-29 公開日 2022-05-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Structures of RGL1 RAS-Association Domain in Complex with KRAS and the Oncogenic G12V Mutant. J.Mol.Biol., 434, 2022
7EZE	Thorarchaeota Rab GTP-gamma-S/Mg2+ (soak) 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION, Thorarchaeota Rab 著者 Robinson, R.C, Tran, L.T. 登録日 2021-06-01 公開日 2022-06-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure of Thor-Rab To Be Published
7EZB	Thorarchaeota Rab bound to GDP 分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Thorarchaeota Rab 著者 Robinson, R.C, Tran, L.T. 登録日 2021-06-01 公開日 2022-06-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structure of Thor-Rab To Be Published
7EZD	Thorarchaeota Rab co-crystallized with GTP gamma-S 分子名称: 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, Chains: A,B, GUANOSINE-5'-DIPHOSPHATE 著者 Robinson, R.C, Tran, L.T. 登録日 2021-06-01 公開日 2022-06-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structure of Thor-Rab To Be Published
7KYZ	Solution structures of full-length K-RAS bound to GDP 分子名称: Isoform 2B of GTPase KRas 著者 Sharma, A.K, Maciag, A.E. 登録日 2020-12-09 公開日 2022-06-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structures of full-length K-RAS bound to GDP To Be Published
7MO1	Crystal Structure of the ZnF1 of Nucleoporin NUP153 in complex with Ran-GDP 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNW	Crystal Structure of Nup358/RanBP2 Ran-binding domain 1 in complex with Ran-GPPNHP 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNZ	Crystal Structure of Nup358/RanBP2 Ran-binding domain 4 in complex with Ran-GPPNHP 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNP	Crystal Structure of the ZnF2 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MO0	Crystal Structure of Nucleoporin NUP50 Ran-Binding Domain in Complex with Ran-GPPNHP 分子名称: GTP-binding nuclear protein Ran, MAGNESIUM ION, Nuclear pore complex protein Nup50, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2022-06-22 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNS	Crystal Structure of the ZnF4 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNR	Crystal Structure of the ZnF3 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNV	Crystal Structure of the ZnF8 of Nucleoporin NUP358/RanBP2 in complex with Ran-GDP 分子名称: E3 SUMO-protein ligase RanBP2, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022
7MNX	Crystal Structure of Nup358/RanBP2 Ran-binding domain 2 in complex with Ran-GPPNHP 分子名称: E3 SUMO-protein ligase RanBP2, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Bley, C.J, Nie, S, Mobbs, G.W, Petrovic, S, Gres, A.T, Liu, X, Mukherjee, S, Harvey, S, Huber, F.M, Lin, D.H, Brown, B, Tang, A.W, Rundlet, E.J, Correia, A.R, Chen, S, Regmi, S.G, Stevens, T.A, Jette, C.A, Dasso, M, Patke, A, Palazzo, A.F, Kossiakoff, A.A, Hoelz, A. 登録日 2021-05-01 公開日 2022-06-15 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Architecture of the cytoplasmic face of the nuclear pore. Science, 376, 2022

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