PDB: 1375 件ウェブページステータス検索Chemie searchBIRD

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3J82	Electron cryo-microscopy of DNGR-1 in complex with F-actin 分子名称: ADENOSINE-5'-DIPHOSPHATE, Actin, cytoplasmic 1, ... 著者 Hanc, P, Fujii, T, Yamada, Y, Huotari, J, Schulz, O, Ahrens, S, Kjaer, S, Way, M, Namba, K, Reis e Sousa, C. 登録日 2014-09-25 公開日 2015-05-20 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structure of the Complex of F-Actin and DNGR-1, a C-Type Lectin Receptor Involved in Dendritic Cell Cross-Presentation of Dead Cell-Associated Antigens. Immunity, 42, 2015
1U70	Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase 分子名称: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cody, V. 登録日 2004-08-02 公開日 2005-02-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005
1U72	Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH 分子名称: Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cody, V. 登録日 2004-08-02 公開日 2005-02-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005
2CI1	Crystal Structure of dimethylarginine dimethylaminohydrolase I in complex with S-nitroso-Lhomocysteine 分子名称: CITRIC ACID, NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1 著者 Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. 登録日 2006-03-17 公開日 2006-05-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.08 Å) 主引用文献 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors. Structure, 14, 2006
2CI5	Crystal structure of Dimethylarginine Dimethylaminohydrolase I in complex with L-homocysteine 分子名称: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, CITRIC ACID, NG, ... 著者 Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. 登録日 2006-03-17 公開日 2006-05-17 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inbitors Structure, 14, 2006
2OAD	Structure of Glutathione-S-Transferase C169A Mutant 分子名称: Glutathione S-transferase P 1, S-(P-NITROBENZYL)GLUTATHIONE 著者 Kyrieleis, O.J, McManus, G, Mantle, T.J, Khan, A.R. 登録日 2006-12-15 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and Kinetic Analyses of Glutathione S-Transferase Mutations TO BE PUBLISHED
1S3V	Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry 分子名称: (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, Dihydrofolate reductase, SULFATE ION 著者 Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. 登録日 2004-01-14 公開日 2004-03-30 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
2CI7	Crystal structure of Dimethylarginine Dimethylaminohydrolase I in complex with Zinc, high pH 分子名称: GLYCINE, NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1, ... 著者 Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. 登録日 2006-03-17 公開日 2006-05-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors. Structure, 14, 2006
1S3W	Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry 分子名称: 6-(OCTAHYDRO-1H-INDOL-1-YLMETHYL)DECAHYDROQUINAZOLINE-2,4-DIAMINE, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE 著者 Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. 登録日 2004-01-14 公開日 2004-03-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
2CI6	Crystal Structure of Dimethylarginine dimethylaminohydrolase I bound with Zinc low pH 分子名称: NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1, ZINC ION 著者 Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. 登録日 2006-03-17 公開日 2006-05-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inbitors Structure, 14, 2006
1S3U	Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry 分子名称: (2R,6S)-6-{[methyl(3,4,5-trimethoxyphenyl)amino]methyl}-1,2,5,6,7,8-hexahydroquinazoline-2,4-diamine, Dihydrofolate reductase, SULFATE ION 著者 Cody, V, Luft, J.R, Pangborn, W, Gangjee, A, Queener, S.F. 登録日 2004-01-14 公開日 2004-03-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Acta Crystallogr.,Sect.D, 60, 2004
2OA7	Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-hexyl glutathione 分子名称: Glutathione S-transferase P 1, S-HEXYLGLUTATHIONE 著者 Kyrieleis, O.J, McManus, G, Mantle, T.J, Khan, A.R. 登録日 2006-12-15 公開日 2007-01-30 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-hexyl glutathione TO BE PUBLISHED
1U71	Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22Arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes with Methotrexate and NADPH 分子名称: 6-(2,5-DIMETHOXY-BENZYL)-5-METHYL-PYRIDO[2,3-D]PYRIMIDINE-2,4-DIAMINE, Dihydrofolate reductase, SULFATE ION 著者 Cody, V, Luft, J.R, Pangborn, W. 登録日 2004-08-02 公開日 2005-02-01 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH. Acta Crystallogr.,Sect.D, 61, 2005
2CI4	Crystal Structure of Dimethylarginine dimethylaminohydrolase I crystal form II 分子名称: NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1 著者 Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. 登録日 2006-03-17 公開日 2006-05-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors. Structure, 14, 2006
2CI3	Crystal Structure of Dimethylarginine dimethylaminohydrolase crystal form I 分子名称: NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE 1 著者 Frey, D, Braun, O, Briand, C, Vasak, M, Grutter, M.G. 登録日 2006-03-17 公開日 2006-05-17 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the Mammalian Nos Regulator Dimethylarginine Dimethylaminohydrolase: A Basis for the Design of Specific Inhibitors. Structure, 14, 2006
2OAC	Mouse C14A Glutathione-S-Transferase Mutant in Complex with S-(p-nitrobenzyl) Glutathione 分子名称: Glutathione S-transferase P 1, S-(P-NITROBENZYL)GLUTATHIONE 著者 Kyrieleis, O.J, McManus, G, Mantle, T.J, Khan, A.R. 登録日 2006-12-15 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and Kinetic Analyses of Glutathione S-Transferase Mutants TO BE PUBLISHED
1EKU	CRYSTAL STRUCTURE OF A BIOLOGICALLY ACTIVE SINGLE CHAIN MUTANT OF HUMAN IFN-GAMMA 分子名称: Interferon gamma, SULFATE ION 著者 Landar, A, Curry, B, Parker, M.H, DiGiacomo, R, Indelicato, S.R, Walter, M.R. 登録日 2000-03-09 公開日 2000-09-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. J.Mol.Biol., 299, 2000
5WI0	Crystal structure of human NAMPT with fragment 2: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one 分子名称: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one, Nicotinamide phosphoribosyltransferase 著者 Longenecker, K.L, Raich, D, Korepanova, A.V. 登録日 2017-07-18 公開日 2018-01-10 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Fragment-based discovery of a potent NAMPT inhibitor. Bioorg. Med. Chem. Lett., 28, 2018
6XR4	Integrative in situ structure of Parkinsons disease-linked human LRRK2 分子名称: Leucine-rich repeat serine/threonine-protein kinase 2 著者 Villa, E, Lasker, K, Audagnotto, M. 登録日 2020-07-10 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (14 Å) 主引用文献 The In Situ Structure of Parkinson's Disease-Linked LRRK2. Cell, 182, 2020
2DHF	CRYSTAL STRUCTURES OF RECOMBINANT HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE AND 5-DEAZOFOLATE 分子名称: 5-DEAZAFOLIC ACID, DIHYDROFOLATE REDUCTASE 著者 Davies /II, J.F, Kraut, J. 登録日 1989-10-25 公開日 1990-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate. Biochemistry, 29, 1990
8VRD	Rigid body fitted model for free recombinant gamma tubulin ring complex. 分子名称: Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ... 著者 Aher, A, Urnavicius, L, Kapoor, T.M. 登録日 2024-01-21 公開日 2024-03-27 実験手法 ELECTRON MICROSCOPY (7 Å) 主引用文献 Rigid body fitted model for free recombinant gamma tubulin ring complex. To be published
8VRK	Rigid body fitted model for refined density map of gamma tubulin ring complex capped microtubule 分子名称: Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ... 著者 Aher, A, Urnavicius, L, Kapoor, T.M. 登録日 2024-01-22 公開日 2024-03-27 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (8.5 Å) 主引用文献 Structure of the gamma-tubulin ring complex-capped microtubule. Nat.Struct.Mol.Biol., 31, 2024
8VRJ	Rigid body fitted model for gamma tubulin ring complex capped microtubule 分子名称: Actin, cytoplasmic 1, Gamma-tubulin complex component 3, ... 著者 Aher, A, Urnavicius, L, Kapoor, T.M. 登録日 2024-01-22 公開日 2024-03-27 最終更新日 2024-07-31 実験手法 ELECTRON MICROSCOPY (7.7 Å) 主引用文献 Structure of the gamma-tubulin ring complex-capped microtubule. Nat.Struct.Mol.Biol., 31, 2024
2C2T	Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6-methylpyrimidine, a novel boron containing, nonclassical Antifolate 分子名称: (S)-2,4-DIAMINO-5-((7,8-DICARBAUNDECABORAN-7-YL)METHYL)-6-METHYLPYRIMIDINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... 著者 leung, A.K.W, reynolds, R.C, riordan, J.M, borhani, D.W. 登録日 2005-09-30 公開日 2007-04-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation. J.Med.Chem., 50, 2007
2C2S	Human Dihydrofolate Reductase Complexed With NADPH and 2,4-Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, A novel boron containing, nonclassical Antifolate 分子名称: 2,4-DIAMINO-5-(1-O-CARBORANYLMETHYL)-6-METHYLPYRIMIDINE, DIHYDROFOLATE REDUCTASE, GLYCEROL, ... 著者 Leung, A.K.W, Reynolds, R.C, Riordan, J.M, Borhani, D.W. 登録日 2005-09-29 公開日 2007-04-10 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation. J.Med.Chem., 50, 2007

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