5WI0

Crystal structure of human NAMPT with fragment 2: 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one

Summary for 5WI0

Entry DOI	10.2210/pdb5wi0/pdb
Descriptor	Nicotinamide phosphoribosyltransferase, 2-[(2-fluorophenyl)amino]-6-propylpyrimidin-4(3H)-one (3 entities in total)
Functional Keywords	nampt, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	111684.41
Authors	Longenecker, K.L.,Raich, D.,Korepanova, A.V. (deposition date: 2017-07-18, release date: 2018-01-10, Last modification date: 2023-10-04)
Primary citation	Korepanova, A.,Longenecker, K.L.,Pratt, S.D.,Panchal, S.C.,Clark, R.F.,Lake, M.,Gopalakrishnan, S.M.,Raich, D.,Sun, C.,Petros, A.M. Fragment-based discovery of a potent NAMPT inhibitor. Bioorg. Med. Chem. Lett., 28:437-440, 2018 Cited by PubMed: 29287958 DOI: 10.1016/j.bmcl.2017.12.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation