PDB: 226707 件ウェブページステータス検索Chemie searchBIRD

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6QM1	Solution NMR of synthetic analogues of nisin and mutacin ring A and ring B - Nisin Ring B (Lan8,11) analogue 分子名称: DAL-PRO-GLY-CYS-LYS 著者 Dickman, R, Mitchell, S.A, Figueiredo, A, Hansen, D.F, Tabor, A.B. 登録日 2019-02-01 公開日 2019-09-11 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B. J.Org.Chem., 84, 2019
5KGQ	NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi 分子名称: Uncharacterized protein 著者 D'Andrea, E.D, Retel, J.S, Diehl, A, Schmieder, P, Oschkinat, H, Pires, J.R. 登録日 2016-06-13 公開日 2017-07-05 最終更新日 2024-06-12 実験手法 SOLUTION NMR 主引用文献 NMR structure and dynamics of Q4DY78, a conserved kinetoplasid-specific protein from Trypanosoma cruzi. J.Struct.Biol., 213, 2021
6YRI	THE CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH CAFFEIC ACID 分子名称: CAFFEIC ACID, Carbonic anhydrase 2, GLYCEROL, ... 著者 D'Ambrosio, K, De Simone, G. 登録日 2020-04-20 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Catechols: a new class of carbonic anhydrase inhibitors. Chem.Commun.(Camb.), 56, 2020
5UZZ	Structure of wild type pre-miR21 apical loop 分子名称: 14-mer Peptide, pre-miR21 著者 Shortridge, M.D, Varani, G. 登録日 2017-02-27 公開日 2017-06-14 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing. ACS Chem. Biol., 12, 2017
8AI6	Crystal structure of radical SAM epimerase EpeE D210A mutant from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and persulfurated cysteine bound 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ... 著者 Polsinelli, I, Legrand, P, Fyfe, C.D, Benjdia, A, Berteau, O. 登録日 2022-07-25 公開日 2024-01-10 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme. Nat.Chem.Biol., 20, 2024
8AI1	Crystal structure of radical SAM epimerase EpeE from Bacillus subtilis with [4Fe-4S] clusters and S-adenosyl-L-homocysteine bound. 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ... 著者 Kubiak, X, Polsinelli, I, Chavas, L.M.G, Legrand, P, Fyfe, C.D, Benjdia, A, Berteau, O. 登録日 2022-07-25 公開日 2024-01-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme. Nat.Chem.Biol., 20, 2024
8AI3	Crystal structure of radical SAM epimerase EpeE C223A mutant from Bacillus subtilis with [4Fe-4S] clusters and S-adenosyl-L-methionine bound 分子名称: 1,2-ETHANEDIOL, GLYCEROL, IRON/SULFUR CLUSTER, ... 著者 Kubiak, X, Chavas, L.M.G, Legrand, P, Polsinelli, I, Fyfe, C.D, Benjdia, A, Berteau, O. 登録日 2022-07-25 公開日 2024-01-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme. Nat.Chem.Biol., 20, 2024
7NPM	X-ray structure of the adduct formed upon reaction of oxaliplatin with human angiogenin 分子名称: Angiogenin, D(-)-TARTARIC ACID, PLATINUM (II) ION 著者 Ferraro, G, Merlino, A. 登録日 2021-02-27 公開日 2022-03-23 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.86 Å) 主引用文献 Oxaliplatin inhibits angiogenin proliferative and cell migration effects in prostate cancer cells. J.Inorg.Biochem., 226, 2022
8QPC	18mer DNA mimic Foldamer with an Aromatic linker in complex with Sac7d V26A/M29A protein 分子名称: DNA-binding protein 7b, N-[2-(2-methyl-1,3-dioxolan-2-yl)phenyl]-2-{[5-(trifluoromethyl)pyridin-2-yl]amino}pyridine-4-carboxamide 著者 Deepak, D, Corvaglia, V, Wu, J, Huc, I. 登録日 2023-10-01 公開日 2023-11-08 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (3.24 Å) 主引用文献 DNA-Mimic Foldamer Recognition of a Chromosomal Protein To Be Published
4QY3	THE CRYSTAL STRUCTURE OF THE COMPLEX of HCAII WITH AN ORTHO-SUBSTITUTED BENZOIC ACID 分子名称: 2-[(S)-benzylsulfinyl]benzoic acid, 4-(HYDROXYMERCURY)BENZOIC ACID, Carbonic anhydrase 2, ... 著者 D'Ambrosio, K, De Simone, G. 登録日 2014-07-23 公開日 2014-12-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Out of the active site binding pocket for carbonic anhydrase inhibitors. Chem.Commun.(Camb.), 51, 2014
7RCB	Crystal Structure of a PMS2 VUS 分子名称: Mismatch repair endonuclease PMS2 著者 D'Arcy, B.M, Prakash, A. 登録日 2021-07-07 公開日 2022-03-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 PMS2 variant results in loss of ATPase activity without compromising mismatch repair. Mol Genet Genomic Med, 10, 2022
7RCK	Crystal Structure of PMS2 with Substrate 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2 著者 D'Arcy, B.M, Prakash, A. 登録日 2021-07-07 公開日 2022-03-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 PMS2 variant results in loss of ATPase activity without compromising mismatch repair. Mol Genet Genomic Med, 10, 2022
7RCI	Crystal Structure of a PMS2 VUS with Substrate 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2 著者 D'Arcy, B.M, Prakash, A. 登録日 2021-07-07 公開日 2022-03-02 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.12 Å) 主引用文献 PMS2 variant results in loss of ATPase activity without compromising mismatch repair. Mol Genet Genomic Med, 10, 2022
8F43	HNH Nuclease Domain from G. stearothermophilus Cas9, K597A mutant 分子名称: CRISPR-associated endonuclease Cas9 著者 D'Ordine, A.M, Belato, H.B, Lisi, G.P, Jogl, G. 登録日 2022-11-10 公開日 2022-12-21 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Disruption of electrostatic contacts in the HNH nuclease from a thermophilic Cas9 rewires allosteric motions and enhances high-temperature DNA cleavage. J.Chem.Phys., 157, 2022
8SP5	LINE-1 retrotransposon endonuclease domain complex with Mn2+ 分子名称: LINE-1 retrotransposon endonuclease, MANGANESE (II) ION, SULFATE ION 著者 D'Ordine, A.M, Jogl, G, Sedivy, J.M. 登録日 2023-05-02 公開日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. Nat Commun, 15, 2024
4RO4	Sequence and structure of a self-assembled 3-D DNA crystal: D(GGAAACGTTGGAG) 分子名称: D(GGAAACGTTGGAG), MAGNESIUM ION 著者 Saoji, M.M, Paukstelis, P.J. 登録日 2014-10-27 公開日 2015-06-17 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Probing the role of sequence in the assembly of three-dimensional DNA crystals. Biopolymers, 103, 2015
7B4T	Broadly neutralizing DARPin bnD.1 in complex with the HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505) 分子名称: Broadly neutralizing DARPin bnD.1, HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505), SULFATE ION 著者 Friedrich, N, Stiegeler, E, Glogl, M, Lemmin, T, Hansen, S, Kadelka, C, Wu, Y, Ernst, P, Maliqi, L, Foulkes, C, Morin, M, Eroglu, M, Liechti, T, Ivan, B, Reinberg, T, Schaefer, J, Karakus, U, Ursprung, S, Mann, A, Rusert, P, Kouyos, R.D, Robinson, J.A, Gunthard, H.F, Pluckthun, A, Trkola, A. 登録日 2020-12-02 公開日 2021-11-24 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nat Commun, 12, 2021
8PPB	Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-3-deoxy-myo-inositol 1,4,6-trisphosphate/ATP/Mn 分子名称: ADENOSINE-5'-TRIPHOSPHATE, D-3-deoxy-myo-inositol 1,4,6-trisphosphate, Inositol-trisphosphate 3-kinase A, ... 著者 Marquez-Monino, M.A, Gonzalez, B. 登録日 2023-07-07 公開日 2024-02-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
8PPH	Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with alpha-D-glucopyranosyl 1,3,4-trisphosphate/ATP/Mn 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Inositol-trisphosphate 3-kinase A, MANGANESE (II) ION, ... 著者 Marquez-Monino, M.A, Gonzalez, B. 登録日 2023-07-07 公開日 2024-02-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
8PPI	Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosylmethanol 3,4,1'-trisphosphate/ATP/Mn 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Inositol-trisphosphate 3-kinase A, MANGANESE (II) ION, ... 著者 Marquez-Monino, M.A, Gonzalez, B. 登録日 2023-07-07 公開日 2024-02-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
8PPF	Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with beta-D-glucopyranosyl 1,3,4-trisphosphate/AMP-PNP/Mg 分子名称: Inositol-trisphosphate 3-kinase A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... 著者 Marquez-Monino, M.A, Gonzalez, B. 登録日 2023-07-07 公開日 2024-02-28 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
7AAV	Human pre-Bact-2 spliceosome core structure 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-04 公開日 2020-12-09 最終更新日 2020-12-30 実験手法 ELECTRON MICROSCOPY (4.2 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
8JIU	Cryo-EM structure of the GLP-1R/GCGR dual agonist SAR425899-bound human GCGR-Gs complex 分子名称: Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Yang, L, Zhou, Q.T, Dai, A.T, Zhao, F.H, Chang, R.L, Ying, T.L, Wu, B.L, Yang, D.H, Wang, M.W, Cong, Z.T. 登録日 2023-05-27 公開日 2023-09-13 最終更新日 2024-10-16 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Structural analysis of the dual agonism at GLP-1R and GCGR. Proc.Natl.Acad.Sci.USA, 120, 2023
8AI4	Crystal structure of radical SAM epimerase EpeE C223A mutant from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and RiPP peptide 5 bound 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Polsinelli, I, Fyfe, C.D, Legrand, P, Kubiak, X, Chavas, L.M.G, Berteau, O, Benjdia, A. 登録日 2022-07-25 公開日 2024-01-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme. Nat.Chem.Biol., 20, 2024
8AI2	Crystal structure of radical SAM epimerase EpeE from Bacillus subtilis with [4Fe-4S] clusters, S-adenosyl-L-homocysteine and RiPP peptide 5 bound 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IRON/SULFUR CLUSTER, ... 著者 Polsinelli, I, Fyfe, C.D, Legrand, P, Kubiak, X, Chavas, L.M.G, Berteau, O, Benjdia, A. 登録日 2022-07-25 公開日 2024-01-10 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.393 Å) 主引用文献 Structural and mechanistic basis for RiPP epimerization by a radical SAM enzyme. Nat.Chem.Biol., 20, 2024

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