8PPB

Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-3-deoxy-myo-inositol 1,4,6-trisphosphate/ATP/Mn

Summary for 8PPB

• Entry DOI: 10.2210/pdb8ppb/pdb
• Related: 8PP8 8PP9 8PPA
• Descriptor: Inositol-trisphosphate 3-kinase A, D-3-deoxy-myo-inositol 1,4,6-trisphosphate, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: inositol polyphosphate, insp, inositol kinase, ip3k, calcium, insp3, ip3, ipk, ip3 3-k, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 66373.22

Authors

Marquez-Monino, M.A.,Gonzalez, B. (deposition date: 2023-07-07, release date: 2024-02-28, Last modification date: 2024-03-27)

• Primary citation: Marquez-Monino, M.A.,Ortega-Garcia, R.,Whitfield, H.,Riley, A.M.,Infantes, L.,Garrett, S.W.,Shipton, M.L.,Brearley, C.A.,Potter, B.V.L.,Gonzalez, B.; Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity.; Nat Commun, 15:1502-1502, 2024; PubMed: 38374076; DOI: 10.1038/s41467-024-45917-5

Experimental method

X-RAY DIFFRACTION (1.8 Å)