8PPB
Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-3-deoxy-myo-inositol 1,4,6-trisphosphate/ATP/Mn
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Inositol-trisphosphate 3-kinase A | polymer | 279 | 31877.3 | 2 | UniProt (P23677) Pfam (PF03770) | Homo sapiens (human) | Inositol 1,4,5-trisphosphate 3-kinase A,IP3 3-kinase A,IP3K A,InsP 3-kinase A |
| 2 | C, J (A, B) | D-3-deoxy-myo-inositol 1,4,6-trisphosphate | non-polymer | 404.1 | 2 | Chemie (3I2) | |||
| 3 | D, K (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | E, F, L, M (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 5 | G, H, I, N, O... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | Q, R (A, B) | water | water | 18.0 | 346 | Chemie (HOH) |
Sequence modifications
A, B: 188 - 461 (UniProt: P23677)
| PDB | External Database | Details |
|---|---|---|
| Gly 183 | - | expression tag |
| Ser 184 | - | expression tag |
| His 185 | - | expression tag |
| Met 186 | - | expression tag |
| Ser 187 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63754.5 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2618.7 | |
| All* | Total formula weight | 66373.2 |
