8PPH

Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with alpha-D-glucopyranosyl 1,3,4-trisphosphate/ATP/Mn

Summary for 8PPH

Entry DOI	10.2210/pdb8pph/pdb
Related	8PP8 8PP9 8PPA 8PPB 8PPC 8PPD 8PPE 8PPF 8PPG
Descriptor	Inositol-trisphosphate 3-kinase A, ADENOSINE-5'-TRIPHOSPHATE, alpha-D-glucopyranosyl 1,3,4-trisphosphate, ... (6 entities in total)
Functional Keywords	inositol polyphosphate, insp, inositol kinase, ip3k, calcium, insp3, ip3, ipk, ip3 3-k, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	65971.31
Authors	Marquez-Monino, M.A.,Gonzalez, B. (deposition date: 2023-07-07, release date: 2024-02-28, Last modification date: 2024-03-27)
Primary citation	Marquez-Monino, M.A.,Ortega-Garcia, R.,Whitfield, H.,Riley, A.M.,Infantes, L.,Garrett, S.W.,Shipton, M.L.,Brearley, C.A.,Potter, B.V.L.,Gonzalez, B. Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15:1502-1502, 2024 Cited by PubMed: 38374076 DOI: 10.1038/s41467-024-45917-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation