PDB: 1138 件ウェブページステータス検索Chemie searchBIRD

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2FA9	The crystal structure of Sar1[H79G]-GDP provides insight into the coat-controlled GTP hydrolysis in the disassembly of COP II 分子名称: GTP-binding protein SAR1b, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Rao, Y, Huang, M, Yuan, C, Bian, C, Hou, X. 登録日 2005-12-07 公開日 2006-09-05 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP II Chin.J.Struct.Chem., 25, 2006
2F8I	Human transthyretin (TTR) complexed with Benzoxazole 分子名称: 2-(2,6-DICHLOROPHENYL)-1,3-BENZOXAZOLE-6-CARBOXYLIC ACID, Transthyretin 著者 Palaninathan, S.K, Mohamedmohaideen, N.N, Sacchettini, J.C, Kelly, J.W. 登録日 2005-12-02 公開日 2005-12-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.541 Å) 主引用文献 Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action Angew.Chem.Int.Ed.Engl., 42, 2003
3CBR	Crystal structure of human Transthyretin (TTR) at pH3.5 分子名称: Transthyretin 著者 Mohamedmohaideen, N.N, Palaninathan, S.K, Snee, W.C, Kelly, J.W, C Sacchettini, J. 登録日 2008-02-22 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J.Mol.Biol., 382, 2008
2G3X	Crystal structure of Transthyretin mutant I84S at acidic pH 分子名称: Transthyretin 著者 Pasquato, N, Folli, C, Berni, R, Zanotti, G. 登録日 2006-02-21 公開日 2007-01-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin. J.Mol.Biol., 366, 2007
8W43	X-ray crystal structure of V30M-TTR in complex with piceatannol 分子名称: PICEATANNOL, SODIUM ION, Transthyretin 著者 Yokoyama, T. 登録日 2023-08-23 公開日 2023-11-22 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.302 Å) 主引用文献 Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
8W45	X-ray crystal structure of V30M-TTR in complex with pinostilbene 分子名称: 3-[(E)-2-(4-hydroxyphenyl)ethenyl]-5-methoxy-phenol, SODIUM ION, Transthyretin 著者 Yokoyama, T. 登録日 2023-08-23 公開日 2023-11-22 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.1 Å) 主引用文献 Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
8W47	X-ray crystal structure of V30M-TTR in complex with isorhapontigenin 分子名称: 5-[(~{E})-2-(3-methoxy-4-oxidanyl-phenyl)ethenyl]benzene-1,3-diol, SODIUM ION, Transthyretin 著者 Yokoyama, T. 登録日 2023-08-23 公開日 2023-11-22 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Resveratrol Derivatives Inhibit Transthyretin Fibrillization: Structural Insights into the Interactions between Resveratrol Derivatives and Transthyretin. J.Med.Chem., 66, 2023
2FLM	Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (6 carbon linker) 分子名称: 4'-{6-[4-(2-CARBOXYPHENYLAMINO)-PHENOXY]-HEXYLOXY}-BIPHENYL-4-CARBOXYLIC ACID, Transthyretin 著者 Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C. 登録日 2006-01-06 公開日 2006-02-28 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. J.Am.Chem.Soc., 125, 2003
8W1N	Structure of transthyretin pathogenic mutation A120S 分子名称: Transthyretin 著者 Ferguson, J.A, Stanfield, R.L, Wright, P.E. 登録日 2024-02-16 公開日 2024-02-28 最終更新日 2024-08-28 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer. Protein Sci., 33, 2024
8W2W	Structure of transthyretin synthetic mutation A120L 分子名称: Transthyretin 著者 Yang, K, Sun, X, Ferguson, J.A, Stanfield, R.L, Wright, P.E. 登録日 2024-02-21 公開日 2024-02-28 最終更新日 2024-08-28 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Mispacking of the F87 sidechain drives aggregation-promoting conformational fluctuations in the subunit interfaces of the transthyretin tetramer. Protein Sci., 33, 2024
2GAB	Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4-hydroxy-3,3',5,4'-tetrachlorobiphenyl 分子名称: 3,3',4',5-TETRACHLOROBIPHENYL-4-OL, Transthyretin 著者 Palaninathan, S.K, Smith, C, Safe, S.H, Kelly, J.W, Sacchettini, J.C. 登録日 2006-03-08 公開日 2006-03-21 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity Chem.Biol., 11, 2004
2G4G	Crystal structure of human transthyretin at pH 4.6 分子名称: Transthyretin 著者 Pasquato, N, Folli, C, Berni, R, Zanotti, G. 登録日 2006-02-22 公開日 2007-01-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin. J.Mol.Biol., 366, 2007
2FBR	Human transthyretin (TTR) complexed with bivalant amyloid inhibitor (4 carbon linker) 分子名称: 4'-(4-{4-[(2-CARBOXYPHENYL)AMINO]PHENOXY}BUTOXY)-1,1'-BIPHENYL-4-CARBOXYLIC ACID, Transthyretin 著者 Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C. 登録日 2005-12-09 公開日 2005-12-27 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization. J.Am.Chem.Soc., 125, 2003
2G4E	Crystal structure of transthyretin mutant I84A at neutral pH 分子名称: Transthyretin 著者 Pasquato, N, Folli, C, Berni, R, Zanotti, G. 登録日 2006-02-22 公開日 2007-01-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin. J.Mol.Biol., 366, 2007
2F7I	Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid 分子名称: 2',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID, Transthyretin 著者 Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C. 登録日 2005-11-30 公開日 2005-12-13 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis. J.Med.Chem., 47, 2004
3D7P	Crystal structure of human Transthyretin (TTR) at pH 4.0 分子名称: Transthyretin 著者 Palaninathan, S.K, Mohamedmohaideen, N.N, Snee, W.C, Kelly, J.W, Sacchettini, J.C. 登録日 2008-05-21 公開日 2008-08-12 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Structural insight into pH-induced conformational changes within the native human transthyretin tetramer. J.Mol.Biol., 382, 2008
2GFU	NMR solution structure of the PWWP domain of Mismatch repair protein hMSH6 分子名称: DNA mismatch repair protein MSH6 著者 Laguri, C, Friedrich, N, Axt, M, Gilquin, B, Zinn-Justin, S, Couprie, J. 登録日 2006-03-23 公開日 2007-04-10 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 The PWWP domain of Mismatch Repair protein hMSH6 is involved in double stranded and single stranded DNA binding To be Published
3CN3	Human transthyretin (TTR) in complex with 1,3-Dibromo-2-hydroxy-5-phenoxybenzene 分子名称: 2,6-dibromo-4-phenoxyphenol, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2008-03-24 公開日 2008-10-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
3CFQ	Crystal structure of human wild-type transthyretin in complex with diclofenac 分子名称: 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, Transthyretin 著者 Lima, L.-M.T.R, Foguel, D, Polikarpov, I. 登録日 2008-03-04 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010
3CXF	Crystal structure of transthyretin variant Y114H 分子名称: Transthyretin 著者 Cendron, L, Zanotti, G, Folli, C, Alfieri, B, Pasquato, N, Berni, R. 登録日 2008-04-24 公開日 2009-04-07 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and mutational analyses of protein-protein interactions between transthyretin and retinol-binding protein. Febs J., 275, 2008
3CN4	Human transthyretin (TTR) in complex with N-(3,5-Dibromo-4-hydroxyphenyl)benzamide 分子名称: N-(3,5-dibromo-4-hydroxyphenyl)benzamide, Transthyretin 著者 Connelly, S, Wilson, I.A. 登録日 2008-03-24 公開日 2008-10-28 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J.Med.Chem., 51, 2008
2H4E	Crystal structure of Cys10 sulfonated transthyretin 分子名称: SULFATE ION, Transthyretin 著者 Gales, L, Damas, A.M. 登録日 2006-05-24 公開日 2007-01-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Structural basis for the protective role of sulfite against transthyretin amyloid formation. Biochim.Biophys.Acta, 1774, 2007
2G3Z	Crystal structure of Transthyretin mutant I84A at low pH 分子名称: Transthyretin 著者 Pasquato, N, Folli, C, Berni, R, Zanotti, G. 登録日 2006-02-21 公開日 2007-01-16 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin. J.Mol.Biol., 366, 2007
2G5U	Human Transthyretin (TTR) Complexed with Hydroxylated polychlorinated Biphenyl-4,4'-dihydroxy-3,3',5,5'-tetrachlorobiphenyl 分子名称: 3,5,3',5'-TETRACHLORO-BIPHENYL-4,4'-DIOL, Transthyretin 著者 Palaninathan, S.K, Smith, C, Safe, S.H, Kelly, J.W, Sacchettini, J.C. 登録日 2006-02-23 公開日 2006-03-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity Chem.Biol., 11, 2004
3CFN	Crystal structure of human transthyretin in complex with 1-anilino-8-naphthalene sulfonate 分子名称: 8-ANILINO-1-NAPHTHALENE SULFONATE, Transthyretin 著者 Lima, L.-M.T.R, Foguel, D, Polikarpov, I. 登録日 2008-03-04 公開日 2009-03-03 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Identification of a novel ligand binding motif in the transthyretin channel. Bioorg.Med.Chem., 18, 2010

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