2G4G

Crystal structure of human transthyretin at pH 4.6

Summary for 2G4G

Entry DOI	10.2210/pdb2g4g/pdb
Related	1F41 2G3X 2G3Z 2G4E
Descriptor	Transthyretin (2 entities in total)
Functional Keywords	ttr, amyloid fibrils formation, point mutations, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	27554.72
Authors	Pasquato, N.,Folli, C.,Berni, R.,Zanotti, G. (deposition date: 2006-02-22, release date: 2007-01-16, Last modification date: 2023-10-25)
Primary citation	Pasquato, N.,Berni, R.,Folli, C.,Alfieri, B.,Cendron, L.,Zanotti, G. Acidic pH-induced conformational changes in amyloidogenic mutant transthyretin. J.Mol.Biol., 366:711-719, 2007 Cited by PubMed: 17196219 DOI: 10.1016/j.jmb.2006.11.076 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation