PDB: 95775 件ウェブページステータス検索Chemie searchBIRD

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8JPS	Structure of Duffy Antigen Receptor for Chemokines (DARC)/ACKR1 in complex with the chemokine, CCL7 (Composite map) 分子名称: Atypical chemokine receptor 1, C-C motif chemokine 7 著者 Banerjee, R, Khanppnavar, B, Maharana, J, Saha, S, Korkhov, V.M, Shukla, A.K. 登録日 2023-06-12 公開日 2024-07-31 最終更新日 2024-09-04 実験手法 ELECTRON MICROSCOPY (3.65 Å) 主引用文献 Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor. Cell, 187, 2024
8P8X	Crystal structure of a pathogenic mutant variant of human mitochodnrial PheRS 分子名称: PHENYLALANINE, Phenylalanine--tRNA ligase, mitochondrial 著者 Chen, W, Kuhle, B. 登録日 2023-06-03 公開日 2023-08-16 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 Clinical and molecular characterization of novel FARS2 variants causing neonatal mitochondrial disease. Mol.Genet.Metab., 140, 2023
8PKY	Structure of Chloroflexus aggregans flavin based fluorescent protein (CagFbFP) Q148V variant 分子名称: FLAVIN MONONUCLEOTIDE, histidine kinase 著者 Nikolaev, A, Remeeva, A, Gushchin, I. 登録日 2023-06-27 公開日 2023-07-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Two distinct mechanisms of flavoprotein spectral tuning revealed by low-temperature and time-dependent spectroscopy. Protein Sci., 33, 2024
8PM1	Structure of Chloroflexus aggregans flavin based fluorescent protein (CagFbFP) variant I52V A85Q 分子名称: FLAVIN MONONUCLEOTIDE, histidine kinase 著者 Nikolaev, A, Remeeva, A, Gushchin, I. 登録日 2023-06-27 公開日 2023-07-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Two distinct mechanisms of flavoprotein spectral tuning revealed by low-temperature and time-dependent spectroscopy. Protein Sci., 33, 2024
8PEK	Structure of the dimeric, periplasmic domain of ExbD 分子名称: Biopolymer transport protein ExbD 著者 Zinke, M, Bardiaux, B, Izadi-Pruneyre, N. 登録日 2023-06-14 公開日 2023-09-06 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake. Nat Commun, 15, 2024
8PX2	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 1,3-dimethyl-5-(1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one 分子名称: 1,3-dimethyl-5-[1-(oxan-4-ylmethyl)benzimidazol-2-yl]pyridin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Bromodomain-containing protein 2 著者 Chung, C.W. 登録日 2023-07-22 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.622 Å) 主引用文献 Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PX8	C-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH (S)-5-(1-((1-acetylpiperidin-3-yl)methyl)-5-bromo-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[5-bromanyl-1-[[(3~{S})-1-ethanoylpiperidin-3-yl]methyl]benzimidazol-2-yl]-1,3-dimethyl-pyridin-2-one, ... 著者 Chung, C.W. 登録日 2023-07-22 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.603 Å) 主引用文献 Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
8PXA	N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH (S)-5-(1-((1-(1-isopropylpiperidine-4-carbonyl)piperidin-3-yl)methyl)-1H-benzo[d]imidazol-2-yl)-1,3-dimethylpyridin-2(1H)-one 分子名称: 1,3-dimethyl-5-[1-[[(3~{S})-1-(1-propan-2-ylpiperidin-4-yl)carbonylpiperidin-3-yl]methyl]benzimidazol-2-yl]pyridin-2-one, Bromodomain-containing protein 4 著者 Chung, C. 登録日 2023-07-22 公開日 2023-10-18 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. J.Med.Chem., 66, 2023
3BLM	REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM STAPHYLOCOCCUS AUREUS PC1 AT 2.0 分子名称: BETA-LACTAMASE 著者 Herzberg, O, Moult, J. 登録日 1990-12-03 公開日 1991-01-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Refined crystal structure of beta-lactamase from Staphylococcus aureus PC1 at 2.0 A resolution. J.Mol.Biol., 217, 1991
8PPM	IL-12Rb1 neutralizing Fab4, crystal kappa variant 分子名称: Fab4 Light chain, crystal kappa variant, Fab4 heavy chain, ... 著者 Bloch, Y, Savvides, S.N. 登録日 2023-07-07 公開日 2024-02-07 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
8PND	The ES3 intermediate of hydroxymethylbilane synthase R167Q variant 分子名称: 1,2-ETHANEDIOL, 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid, GLYCEROL, ... 著者 Saeter, M.C, Bustad, H.J, Laitaoja, M, Janis, J, Martinez, A, Aarsand, A.K, Kallio, J.P. 登録日 2023-06-30 公開日 2023-11-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 One ring closer to a closure: the crystal structure of the ES 3 hydroxymethylbilane synthase intermediate. Febs J., 291, 2024
8OXU	Crystal Structure of the Hsp90-LA1011 Complex 分子名称: ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate 著者 Roe, S.M, Prodromou, C. 登録日 2023-05-02 公開日 2023-07-12 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease. Biomolecules, 13, 2023
8P01	Crystal structure of human STING ectodomain in complex with BI 7446, a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer 分子名称: 3-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-18-oxidanyl-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-6~{H}-imidazo[4,5-d]pyridazin-7-one, Stimulator of interferon genes protein 著者 Nar, H. 登録日 2023-05-09 公開日 2023-07-26 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.094 Å) 主引用文献 Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. J.Med.Chem., 66, 2023
8OLU	Leishmania tarentolae proteasome 20S subunit in complex with 1-Benzyl-N-(3-(cyclopropylcarbamoyl)phenyl)-6-oxo-1,6-dihydropyridazine-3-carboxamide 分子名称: Proteasome alpha 1 subunit, putative, Proteasome alpha 5 subunit, ... 著者 Rowland, P. 登録日 2023-03-30 公開日 2023-08-09 最終更新日 2023-08-23 実験手法 ELECTRON MICROSCOPY (2.59 Å) 主引用文献 Structure-Guided Design and Synthesis of a Pyridazinone Series of Trypanosoma cruzi Proteasome Inhibitors. J.Med.Chem., 66, 2023
8Q5E	Crystal structure of PpSB1-LOV protein from Pseudomonas putida with covalent FMN 分子名称: FLAVIN MONONUCLEOTIDE, NICKEL (II) ION, Sensory box protein 著者 Rozeboom, H.J, Fraaije, M.W. 登録日 2023-08-09 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor. J.Am.Chem.Soc., 145, 2023
8Q5F	Crystal structure of miniSOG protein from Arabidopsis thaliana with covalent FMN 分子名称: FLAVIN MONONUCLEOTIDE, miniSOG 著者 Rozeboom, H.J, Fraaije, M.W. 登録日 2023-08-09 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fixing Flavins: Hijacking a Flavin Transferase for Equipping Flavoproteins with a Covalent Flavin Cofactor. J.Am.Chem.Soc., 145, 2023
2XVA	Crystal structure of the tellurite detoxification protein TehB from E. coli in complex with sinefungin 分子名称: SINEFUNGIN, TELLURITE RESISTANCE PROTEIN TEHB, ZINC ION 著者 Choudhury, H.G, Cameron, A.D, Iwata, S, Beis, K. 登録日 2010-10-25 公開日 2011-02-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structure and Mechanism of the Chalcogen Detoxifying Protein Tehb from Escherichia Coli. Biochem.J., 435, 2011
8PB1	Cryo-EM structure of a pre-dimerized murine IL-12 complete extracellular signaling complex (Class 1), obtained after local refinement. 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1,Death-associated protein kinase 1, Interleukin-12 receptor subunit beta-2,Calmodulin-1, ... 著者 Felix, J, Bloch, Y, Savvides, S.N. 登録日 2023-06-08 公開日 2024-02-07 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31, 2024
1I83	BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN COMPLEXED WITH N1,N14-BIS((S-METHYL)ISOTHIOUREIDO)TETRADECANE (H4B FREE) 分子名称: ACETATE ION, GLYCEROL, N1,N14-BIS((S-METHYL)ISOTHIOUREIDO)TETRADECANE, ... 著者 Raman, C.S, Li, H, Martasek, P, Babu, B.R, Griffith, O.W, Masters, B.S.S, Poulos, T.L. 登録日 2001-03-12 公開日 2001-08-08 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase. J.Biol.Chem., 276, 2001
8PWH	Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, Pertuzumab Fab light chain, ... 著者 Ruedas, R, Vuillemot, R, Tubiana, T, Winter, J.M, Pieri, L, Arteni, A.A, Samson, C, Jonic, J, Mathieu, M, Bressanelli, S. 登録日 2023-07-20 公開日 2024-02-21 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.17 Å) 主引用文献 Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex. J.Struct.Biol., 216, 2024
8POK	Cryo-EM structure of cell-free synthesized human histamine H2 receptor coupled to heterotrimeric Gs protein in lipid environment 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, HISTAMINE, ... 著者 Schnelle, K, Koeck, Z, Persechino, M, Umbach, S, Schihada, H, Januliene, D, Parey, K, Pockes, S, Kolb, P, Doetsch, V, Moeller, A, Hilger, D, Bernhard, F. 登録日 2023-07-05 公開日 2024-03-06 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structure of cell-free synthesized human histamine 2 receptor/G s complex in nanodisc environment. Nat Commun, 15, 2024
1JQE	Crystal Structure Analysis of Human Histamine Methyltransferase (Ile105 Polymorphic Variant) Complexed with AdoHcy and Antimalarial Drug Quinacrine 分子名称: Histamine N-Methyltransferase, QUINACRINE, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Horton, J.R, Sawada, K, Nishibori, M, Zhang, X, Cheng, X. 登録日 2001-08-06 公開日 2002-08-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.91 Å) 主引用文献 Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons. Structure, 9, 2001
8Q56	PglX methyltransferase of Salmonella BREX phage defence system (aka BrxX) bound to inhibitor Ocr 分子名称: Protein Ocr, S-ADENOSYLMETHIONINE, site-specific DNA-methyltransferase (adenine-specific) 著者 Went, S.C, Blower, T.R. 登録日 2023-08-08 公開日 2024-08-21 最終更新日 2024-09-04 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure and rational engineering of the PglX methyltransferase and specificity factor for BREX phage defence. Nat Commun, 15, 2024
8QFC	UFL1 E3 ligase bound 60S ribosome 分子名称: 60S ribosomal protein L10a, CDK5 regulatory subunit-associated protein 3, DDRGK domain-containing protein 1, ... 著者 Makhlouf, L, Zeqiraj, E, Kulathu, Y. 登録日 2023-09-04 公開日 2024-02-21 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons. Nature, 627, 2024
8Q6J	Atomic structure and conformational variability of the HER2-Trastuzumab-Pertuzumab complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Pertuzumab Fab heavy chain, Pertuzumab Fab light chain, ... 著者 Ruedas, R, Vuillemot, R, Tubiana, T, Winter, J.M, Pieri, L, Arteni, A.A, Samson, C, Jonic, J, Mathieu, M, Bressanelli, S. 登録日 2023-08-11 公開日 2023-09-20 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Structure and conformational variability of the HER2-trastuzumab-pertuzumab complex. J.Struct.Biol., 216, 2024

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