2LP5
 
 | | Native Structure of the Fyn SH3 A39V/N53P/V55L | | 分子名称: | Tyrosine-protein kinase Fyn | | 著者 | Neudecker, P, Robustelli, P, Cavalli, A, Vendruscolo, M, Kay, L.E. | | 登録日 | 2012-02-06 | | 公開日 | 2012-05-16 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of an intermediate state in protein folding and aggregation.
Science, 336, 2012
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2L3C
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2GNC
 | | Crystal structure of srGAP1 SH3 domain in the slit-robo signaling pathway | | 分子名称: | SLIT-ROBO Rho GTPase-activating protein 1 | | 著者 | Li, X, Liu, Y, Gao, F, Bartlam, M, Wu, J.Y, Rao, Z. | | 登録日 | 2006-04-10 | | 公開日 | 2006-07-18 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis of Robo Proline-rich Motif Recognition by the srGAP1 Src Homology 3 Domain in the Slit-Robo Signaling Pathway
J.Biol.Chem., 281, 2006
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2GNI
 | | PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077) | | 分子名称: | 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, cAMP-dependent protein kinase inhibitor alpha, cAMP-dependent protein kinase, ... | | 著者 | Bonn, S, Herrero, S, Breitenlechner, C.B, Engh, R.A, Gassel, M, Bossemeyer, D. | | 登録日 | 2006-04-10 | | 公開日 | 2006-05-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity
J.Biol.Chem., 281, 2006
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2GNV
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4MAO
 | | RSK2 T493M C-Terminal Kinase Domain in Complex with RMM58 | | 分子名称: | (2Z)-2-(1H-1,2,4-triazol-1-yl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]prop-2-enenitrile, Ribosomal protein S6 kinase alpha-3, SODIUM ION | | 著者 | Miller, R.M, Taunton, J. | | 登録日 | 2013-08-16 | | 公開日 | 2014-10-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design of reversible, cysteine-targeted Michael acceptors guided by kinetic and computational analysis.
J.Am.Chem.Soc., 136, 2014
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2GR6
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2LFO
 | | NMR structure of cl-BABP/SS complexed with glycochenodeoxycholic and glycocholic acids | | 分子名称: | Fatty acid-binding protein, liver, GLYCOCHENODEOXYCHOLIC ACID, ... | | 著者 | Tomaselli, S, Cogliati, C, Pagano, K, Zetta, L, Zanzoni, S, Assfalg, M, Molinari, H, Ragona, L. | | 登録日 | 2011-07-07 | | 公開日 | 2012-07-11 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A disulfide bridge allows for site-selective binding in liver bile acid binding protein thereby stabilising the orientation of key amino acid side chains.
Chemistry, 18, 2012
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2LKX
 | | NMR structure of the homeodomain of Pitx2 in complex with a TAATCC DNA binding site | | 分子名称: | DNA (5'-D(*CP*GP*GP*GP*GP*AP*TP*TP*AP*GP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*CP*TP*AP*AP*TP*CP*CP*CP*CP*G)-3'), Pituitary homeobox 3 | | 著者 | Baird-Titus, J.M, Doerdelmann, T, Chaney, B.A, Clark-Baldwin, K, Dave, V, Ma, J. | | 登録日 | 2011-10-21 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the K50 class homeodomain PITX2 bound to DNA and implications for mutations that cause Rieger syndrome
Biochemistry, 44, 2005
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2GYR
 | | Crystal structure of human artemin | | 分子名称: | Neurotrophic factor artemin, isoform 3 | | 著者 | Wang, X.Q. | | 登録日 | 2006-05-09 | | 公開日 | 2006-06-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14, 2006
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2LBS
 | | Solution structure of double-stranded RNA binding domain of S. cerevisiae RNase III (Rnt1p) in complex with AAGU tetraloop hairpin | | 分子名称: | RNA (32-MER), Ribonuclease 3 | | 著者 | Wang, Z, Hartman, E, Roy, K, Chanfreau, G, Feigon, J. | | 登録日 | 2011-04-06 | | 公開日 | 2011-08-31 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a Yeast RNase III dsRBD Complex with a Noncanonical RNA Substrate Provides New Insights into Binding Specificity of dsRBDs.
Structure, 19, 2011
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2GKG
 | | Receiver domain from Myxococcus xanthus social motility protein FrzS | | 分子名称: | response regulator homolog | | 著者 | Echols, N, Fraser, J, Merlie, J, Zusman, D, Alber, T. | | 登録日 | 2006-04-01 | | 公開日 | 2007-03-13 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | An atypical receiver domain controls the dynamic polar localization of the Myxococcus xanthus social motility protein FrzS.
Mol.Microbiol., 65, 2007
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2GKR
 | | Crystal structure of the N-terminally truncated OMTKY3-del(1-5) | | 分子名称: | CHLORIDE ION, Ovomucoid | | 著者 | Lee, T.W, Qasim, M.A, Laskowski Jr, M, James, M.N.G. | | 登録日 | 2006-04-03 | | 公開日 | 2007-02-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Structural Insights into the Non-additivity Effects in the Sequence-to-Reactivity Algorithm for Serine Peptidases and their Inhibitors.
J.Mol.Biol., 367, 2007
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2PKC
 | | CRYSTAL STRUCTURE OF CALCIUM-FREE PROTEINASE K AT 1.5 ANGSTROMS RESOLUTION | | 分子名称: | PROTEINASE K, SODIUM ION | | 著者 | Mueller, A, Hinrichs, W, Wolf, W.M, Saenger, W. | | 登録日 | 1993-06-04 | | 公開日 | 1994-01-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal structure of calcium-free proteinase K at 1.5-A resolution.
J.Biol.Chem., 269, 1994
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2PZG
 | | Minimal human CFTR first nucleotide binding domain as a monomer | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, GLYCEROL, ... | | 著者 | Atwell, S, Conners, K, Emtage, S, Gheyi, T, Glenn, N.R, Hendle, J, Lewis, H.A, Lu, F, Rodgers, L.A, Romero, R, Sauder, J.M, Smith, D, Tien, H, Wasserman, S.R, Zhao, X. | | 登録日 | 2007-05-18 | | 公開日 | 2007-10-09 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
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2H4R
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2Q0N
 | | Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, Serine/threonine-protein kinase PAK 4, ... | | 著者 | Filippakopoulos, P, Eswaran, J, Turnbull, A, Papagrigoriou, E, Pike, A.W, von Delft, F, Sundstrom, M, Edwards, A, Arrowsmith, C.H, Weigelt, J, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2007-05-22 | | 公開日 | 2007-06-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure of human p21 activating kinase 4 (PAK4) in complex with a consensus peptide.
To be Published
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2H5K
 | | Crystal Structure of Complex Between the Domain-Swapped Dimeric Grb2 SH2 Domain and Shc-Derived Ligand, Ac-NH-pTyr-Val-Asn-NH2 | | 分子名称: | CACODYLATE ION, Growth factor receptor-bound protein 2, Shc-Derived Ligand | | 著者 | Benfield, A.P, Whiddon, B.B, Martin, S.F. | | 登録日 | 2006-05-26 | | 公開日 | 2006-08-15 | | 最終更新日 | 2017-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Structural and energetic aspects of Grb2-SH2 domain-swapping.
Arch.Biochem.Biophys., 462, 2007
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2GJS
 | | The crystal structure of human RRAD in complex with GDP | | 分子名称: | GTP-binding protein RAD, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | Turnbull, A.P, Yang, X, Soundararajan, M, Schoch, G, Debreczeni, J, Elkins, J.M, Gileadi, C, Berridge, G, Pantic, N, Burgess, N, Smee, C.E.A, Bray, J, von Delft, F, Weigelt, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Doyle, D, Structural Genomics Consortium (SGC) | | 登録日 | 2006-03-31 | | 公開日 | 2006-04-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structure of human RRAD in complex with GDP
To be Published
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2GSX
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2PUU
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2GV0
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2GV6
 | | Crystal Structure of Matriptase with Inhibitor CJ-730 | | 分子名称: | (S)-3-(3-(4-(2-GUANIDINOETHYL)PIPERIDIN-1-YL)-2-(NAPHTHALENE-2-SULFONAMIDO)-3-OXOPROPYL)BENZIMIDAMIDE, Suppressor of tumorigenicity 14 | | 著者 | Bode, W. | | 登録日 | 2006-05-02 | | 公開日 | 2006-06-06 | | 最終更新日 | 2021-06-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Secondary Amides of Sulfonylated 3-Amidinophenylalanine. New Potent and Selective Inhibitors of Matriptase.
J.Med.Chem., 49, 2006
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2PH6
 | | Crystal Structure of Human Beta Secretase Complexed with inhibitor | | 分子名称: | 3-({[(1R)-1-(4-FLUOROPHENYL)ETHYL]AMINO}CARBONYL)-5-[METHYL(METHYLSULFONYL)AMINO]BENZYL ALPHA-METHYL-D-PHENYLALANINATE, Beta-secretase 1, SULFATE ION | | 著者 | Munshi, S. | | 登録日 | 2007-04-10 | | 公開日 | 2007-06-05 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
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2GO9
 | | RRM domains 1 and 2 of Prp24 from S. cerevisiae | | 分子名称: | U4/U6 snRNA-associated splicing factor PRP24 | | 著者 | Reiter, N.J, Lee, D.H, Tonelli, M, Kwan, S.K, Brow, D.A, Butcher, S.E. | | 登録日 | 2006-04-12 | | 公開日 | 2007-02-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and interactions of the first three RNA recognition motifs of splicing factor prp24.
J.Mol.Biol., 367, 2007
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