6VYQ
 
 | | Escherichia coli transcription-translation complex A1 (TTC-A1) containing an 15 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | | 著者 | Molodtsov, V, Wang, C, Su, M, Ebright, R.H. | | 登録日 | 2020-02-27 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of transcription-translation coupling.
Science, 369, 2020
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8FIX
 | | Cryo-EM structure of E. coli RNA polymerase backtracked elongation complex harboring a terminal mismatch | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Florez Ariza, A, Wee, L, Tong, A, Canari, C, Grob, P, Nogales, E, Bustamante, C. | | 登録日 | 2022-12-17 | | 公開日 | 2023-03-29 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery.
Cell, 186, 2023
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6E05
 | | Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with cytidine triphosphate solved by precipitant-ligand exchange (crystals grown in sulfate precipitant) | | 分子名称: | ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Thompson, A.P, Wegener, K.L, Bruning, J.B, Polyak, S.W. | | 登録日 | 2018-07-06 | | 公開日 | 2018-10-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Precipitant-ligand exchange technique reveals the ADP binding mode in Mycobacterium tuberculosis dethiobiotin synthetase.
Acta Crystallogr D Struct Biol, 74, 2018
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8F1I
 | | SigN RNA polymerase early-melted intermediate bound to mismatch fragment dhsU36mm1 (-12T) | | 分子名称: | DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Mueller, A.U, Chen, J, Darst, S.A. | | 登録日 | 2022-11-05 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A general mechanism for transcription bubble nucleation in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1J
 | | SigN RNA polymerase early-melted intermediate bound to mismatch DNA fragment dhsU36mm2 (-12A) | | 分子名称: | DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Mueller, A.U, Chen, J, Darst, S.A. | | 登録日 | 2022-11-05 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | A general mechanism for transcription bubble nucleation in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8F1K
 | | SigN RNA polymerase early-melted intermediate bound to full duplex DNA fragment dhsU36 (-12T) | | 分子名称: | DNA (36-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | | 著者 | Mueller, A.U, Chen, J, Darst, S.A. | | 登録日 | 2022-11-05 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | A general mechanism for transcription bubble nucleation in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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2WZ0
 | | L38V SOD1 mutant complexed with aniline. | | 分子名称: | 2-METHOXY-5-METHYLANILINE, COPPER (II) ION, D-SERINE, ... | | 著者 | Antonyuk, S, Strange, R.W, Hasnain, S.S. | | 登録日 | 2009-11-20 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
J.Med.Chem., 53, 2010
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6VCM
 | | Crystal structure of E.coli RppH-DapF in complex with GTP, Mg2+ and F- | | 分子名称: | CHLORIDE ION, Diaminopimelate epimerase, FLUORIDE ION, ... | | 著者 | Gao, A, Vasilyev, N, Kaushik, A, Duan, W, Serganov, A. | | 登録日 | 2019-12-21 | | 公開日 | 2020-02-05 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Principles of RNA and nucleotide discrimination by the RNA processing enzyme RppH.
Nucleic Acids Res., 48, 2020
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2WZ6
 | | G93A SOD1 mutant complexed with Quinazoline. | | 分子名称: | 4-(4-METHYL-1,4-DIAZEPAN-1-YL)-2-(TRIFLUOROMETHYL)QUINAZOLINE, COPPER (II) ION, SULFATE ION, ... | | 著者 | Antonyuk, S.V, Strange, R.W, Hasnain, S.S. | | 登録日 | 2009-11-23 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
J.Med.Chem., 53, 2010
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6VZ7
 | | Escherichia coli transcription-translation complex C1 (TTC-C1) containing a 27 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | | 著者 | Molodtsov, V, Wang, C, Su, M, Ebright, R.H. | | 登録日 | 2020-02-27 | | 公開日 | 2020-09-02 | | 最終更新日 | 2025-03-19 | | 実験手法 | ELECTRON MICROSCOPY (7 Å) | | 主引用文献 | Structural basis of transcription-translation coupling.
Science, 369, 2020
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3G2F
 | | Crystal structure of the kinase domain of bone morphogenetic protein receptor type II (BMPR2) at 2.35 A resolution | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bone morphogenetic protein receptor type-2, ... | | 著者 | Chaikuad, A, Thangaratnarajah, C, Roos, A.K, Filippakopoulos, P, Salah, E, Phillips, C, Keates, T, Fedorov, O, Chalk, R, Petrie, K, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Bullock, A, Structural Genomics Consortium (SGC) | | 登録日 | 2009-01-31 | | 公開日 | 2009-02-17 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
Sci Rep, 9, 2019
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1UXL
 | | I113T mutant of human SOD1 | | 分子名称: | COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ... | | 著者 | Hough, M.A, Grossmann, J.G, Antonyuk, S.V, Strange, R.W, Doucette, P.A, Rodriguez, J.A, Whitson, L.J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S. | | 登録日 | 2004-02-25 | | 公開日 | 2004-03-19 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
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6W6L
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2WZ5
 | | L38V SOD1 mutant complexed with L-methionine. | | 分子名称: | COPPER (II) ION, METHIONINE, SULFATE ION, ... | | 著者 | Antonyuk, S.V, Strange, R.W, Hasnain, S.S. | | 登録日 | 2009-11-23 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
J.Med.Chem., 53, 2010
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6VQH
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4G74
 | | Crystal structure of NDH with Quinone | | 分子名称: | 2,3-DIMETHOXY-5-METHYL-6-(3,11,15,19-TETRAMETHYL-EICOSA-2,6,10,14,18-PENTAENYL)-[1,4]BENZOQUINONE, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... | | 著者 | Li, W, Feng, Y, Ge, J, Yang, M. | | 登録日 | 2012-07-19 | | 公開日 | 2012-10-24 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Structural insight into the type-II mitochondrial NADH dehydrogenases.
Nature, 491, 2012
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2WYZ
 | | L38V SOD1 mutant complexed with UMP | | 分子名称: | COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ... | | 著者 | Antonyuk, S.V, Strange, R.W, Hasnain, S.S. | | 登録日 | 2009-11-20 | | 公開日 | 2010-10-27 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural Discovery of Small Molecule Binding Sites in Cu-Zn Human Superoxide Dismutase Familial Amyotrophic Lateral Sclerosis Mutants Provides Insights for Lead Optimization.
J.Med.Chem., 53, 2010
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3FBY
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4C89
 | | Crystal structure of carboxylesterase LpEst1 from Lactobacillus plantarum: high resolution model | | 分子名称: | ESTERASE, GLYCEROL, MALONATE ION | | 著者 | Alvarez, Y, Esteban-Torres, M, Cortes-Cabrera, A, Gago, F, Acebron, I, Benavente, R, Mardo, K, de-las-Rivas, B, Munoz, R, Mancheno, J.M. | | 登録日 | 2013-09-30 | | 公開日 | 2014-04-02 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Esterase Lpest1 from Lactobacillus Plantarum: A Novel and Atypical Member of the Alpha Beta Hydrolase Superfamily of Enzymes
Plos One, 9, 2014
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8F3C
 | | Cryo-EM consensus structure of Escherichia coli que-PEC (paused elongation complex) RNA Polymerase minus preQ1 ligand | | 分子名称: | DNA (38-MER), DNA (39-MER), DNA-directed RNA polymerase subunit alpha, ... | | 著者 | Porta, J.C, Chauvier, A, Deb, I, Ellinger, E, Frank, A.T, Meze, K, Ohi, M.D, Walter, N.G. | | 登録日 | 2022-11-09 | | 公開日 | 2023-06-21 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis for control of bacterial RNA polymerase pausing by a riboswitch and its ligand.
Nat.Struct.Mol.Biol., 30, 2023
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6VYT
 | | Escherichia coli transcription-translation complex A2 (TTC-A2) containing a 15 nt long mRNA spacer, NusG, and fMet-tRNAs at P-site and E-site | | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ... | | 著者 | Molodtsov, V, Wang, C, Ebright, R.H, Su, M. | | 登録日 | 2020-02-27 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (14 Å) | | 主引用文献 | Structural basis of transcription-translation coupling.
Science, 369, 2020
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4C88
 | | Esterase LpEst1 from Lactobacillus plantarum: native structure | | 分子名称: | ESTERASE | | 著者 | Alvarez, Y, Esteban-Torres, M, Cortes-Cabrera, A, Gago, F, Acebron, I, Benavente, R, Mardo, K, de-las-Rivas, B, Munoz, R, Mancheno, J.M. | | 登録日 | 2013-09-30 | | 公開日 | 2014-04-02 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Esterase Lpest1 from Lactobacillus Plantarum: A Novel and Atypical Member of the Alpha Beta Hydrolase Superfamily of Enzymes
Plos One, 9, 2014
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3GRB
 | | Crystal structure of the F87M/L110M mutant of human transthyretin at pH 6.5 | | 分子名称: | ACETATE ION, GLYCEROL, Transthyretin, ... | | 著者 | Palmieri, L.C, Freire, J.B.B, Foguel, D, Lima, L.M.T.R. | | 登録日 | 2009-03-25 | | 公開日 | 2010-04-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Novel Zn2+-binding sites in human transthyretin: implications for amyloidogenesis and retinol-binding protein recognition.
J.Biol.Chem., 285, 2010
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3H0G
 | | RNA Polymerase II from Schizosaccharomyces pombe | | 分子名称: | DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, DNA-directed RNA polymerase II subunit RPB3, ... | | 著者 | Spahr, H, Calero, G, Bushnell, D.A, Kornberg, R.D. | | 登録日 | 2009-04-09 | | 公開日 | 2009-08-25 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3.65 Å) | | 主引用文献 | Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6UTX
 | | E. coli sigma-S transcription initiation complex with an empty bubble ("Old" crystal) | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Zuo, Y, De, S, Steitz, T.A. | | 登録日 | 2019-10-30 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (4.05 Å) | | 主引用文献 | Structural Insights into Transcription Initiation from De Novo RNA Synthesis to Transitioning into Elongation.
Iscience, 23, 2020
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