3G2F

Crystal structure of the kinase domain of bone morphogenetic protein receptor type II (BMPR2) at 2.35 A resolution

Summary for 3G2F

Entry DOI	10.2210/pdb3g2f/pdb
Descriptor	Bone morphogenetic protein receptor type-2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	kinase, structural genomics, structural genomics consortium, sgc, atp-binding, disease mutation, glycoprotein, magnesium, manganese, membrane, metal-binding, nucleotide-binding, phosphoprotein, receptor, serine/threonine-protein kinase, transferase, transmembrane
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	78894.50
Authors	Chaikuad, A.,Thangaratnarajah, C.,Roos, A.K.,Filippakopoulos, P.,Salah, E.,Phillips, C.,Keates, T.,Fedorov, O.,Chalk, R.,Petrie, K.,Pike, A.C.W.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2009-01-31, release date: 2009-02-17, Last modification date: 2023-09-06)
Primary citation	Chaikuad, A.,Thangaratnarajah, C.,von Delft, F.,Bullock, A.N. Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension. Sci Rep, 9:18351-18351, 2019 Cited by PubMed: 31797984 DOI: 10.1038/s41598-019-54830-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation