6P5I
| Structure of a mammalian 80S ribosome in complex with the Israeli Acute Paralysis Virus IRES (Class 1) | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | 著者 | Acosta-Reyes, F.J, Neupane, R, Frank, J, Fernandez, I.S. | 登録日 | 2019-05-30 | 公開日 | 2019-09-18 | 最終更新日 | 2020-02-26 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs. Embo J., 38, 2019
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6QAJ
| Structure of the tripartite motif of KAP1/TRIM28 | 分子名称: | Endolysin,Transcription intermediary factor 1-beta, ZINC ION | 著者 | Stoll, G.A, Oda, S, Yu, M, Modis, Y. | 登録日 | 2018-12-19 | 公開日 | 2019-07-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | 主引用文献 | Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing. Proc.Natl.Acad.Sci.USA, 116, 2019
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7AAV
| Human pre-Bact-2 spliceosome core structure | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | 登録日 | 2020-09-04 | 公開日 | 2020-12-09 | 最終更新日 | 2020-12-30 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7X3U
| cryo-EM structure of human TRiC-ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2022-03-01 | 公開日 | 2023-06-07 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X3J
| Cryo-EM structure of human TRiC-tubulin-S2 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, ... | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2022-03-01 | 公開日 | 2023-06-07 | 最終更新日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X6Q
| cryo-EM structure of human TRiC-ATP-closed state | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2022-03-08 | 公開日 | 2023-06-07 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7X7Y
| Cryo-EM structure of Human TRiC-ATP-open state | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Cong, Y, Liu, C.X. | 登録日 | 2022-03-10 | 公開日 | 2023-06-07 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Pathway and mechanism of tubulin folding mediated by TRiC/CCT along its ATPase cycle revealed using cryo-EM. Commun Biol, 6, 2023
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7YCX
| The structure of INTAC-PEC complex | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | 登録日 | 2022-07-02 | 公開日 | 2023-03-15 | 最終更新日 | 2023-09-27 | 実験手法 | ELECTRON MICROSCOPY (4.18 Å) | 主引用文献 | Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
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7DN3
| Structure of Human RNA Polymerase III elongation complex | 分子名称: | DNA (5'-D(P*TP*CP*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*TP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase III subunit RPC1, ... | 著者 | Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. | 登録日 | 2020-12-08 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of human RNA polymerase III elongation complex. Cell Res., 31, 2021
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4BKX
| The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex | 分子名称: | ACETATE ION, HISTONE DEACETYLASE 1, METASTASIS-ASSOCIATED PROTEIN MTA1, ... | 著者 | Millard, C.J, Watson, P.J, Celardo, I, Gordiyenko, Y, Cowley, S.M, Robinson, C.V, Fairall, L, Schwabe, J.W.R. | 登録日 | 2013-04-30 | 公開日 | 2013-07-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates. Mol.Cell, 51, 2013
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8ITY
| human RNA polymerase III pre-initiation complex closed DNA 1 | 分子名称: | DNA (82-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | 著者 | Hou, H, Jin, Q, Ren, Y, Wang, Q, Xu, Y. | 登録日 | 2023-03-23 | 公開日 | 2023-06-07 | 最終更新日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structure of the SNAPc-bound RNA polymerase III preinitiation complex. Cell Res., 33, 2023
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3RZW
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2VXD
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6QI9
| Truncated human R2TP complex, structure 4 (ADP-empty) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | 登録日 | 2019-01-18 | 公開日 | 2019-05-15 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.63 Å) | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Sci Adv, 5, 2019
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6QI8
| Truncated human R2TP complex, structure 3 (ADP-filled) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Munoz-Hernandez, H, Rodriguez, C.F, Llorca, O. | 登録日 | 2019-01-18 | 公開日 | 2019-04-10 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM. Sci Adv, 5, 2019
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6ID0
| Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | 登録日 | 2018-09-07 | 公開日 | 2019-03-13 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6XOG
| Structure of SUMO1-ML786519 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOH
| Structure of SUMO1-ML00789344 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOI
| Structure of SUMO1-ML00752641 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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1KPS
| Structural Basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin conjugating enzyme Ubc9 and RanGAP1 | 分子名称: | Ran-GTPase activating protein 1, SULFATE ION, Ubiquitin-like protein SUMO-1 conjugating enzyme | 著者 | Bernier-Villamor, V, Sampson, D.A, Matunis, M.J, Lima, C.D. | 登録日 | 2002-01-02 | 公開日 | 2002-02-13 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. Cell(Cambridge,Mass.), 108, 2002
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6Z2J
| The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | 分子名称: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-05-16 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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6ID1
| Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | 著者 | Zhang, X, Zhan, X, Yan, C, Shi, Y. | 登録日 | 2018-09-07 | 公開日 | 2019-03-13 | 最終更新日 | 2020-10-14 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6SWA
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7ABI
| Human pre-Bact-2 spliceosome | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | 登録日 | 2020-09-07 | 公開日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7AO9
| Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | 分子名称: | Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ... | 著者 | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-10-14 | 公開日 | 2020-11-11 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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