4OIH
 
 | | Importin Alpha in Complex with the Bipartite NLS of Prp20 | | 分子名称: | Guanine nucleotide exchange factor SRM1, Importin subunit alpha-1 | | 著者 | Roman, N, Christie, M, Swarbrick, C.M.D, Kobe, B, Forwood, J.K. | | 登録日 | 2014-01-19 | | 公開日 | 2014-02-19 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
Plos One, 8, 2013
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8G8S
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4MZ5
 | | Structure of importin-alpha: dUTPase NLS complex | | 分子名称: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1 | | 著者 | Marfori, M, Rona, G, Vertessy, B.G, Kobe, B. | | 登録日 | 2013-09-29 | | 公開日 | 2013-11-13 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Acta Crystallogr.,Sect.D, 69, 2013
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1V18
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1EE4
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8VPU
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6BW0
 | | Nipah virus W protein C-terminus in complex with Importin alpha 1 | | 分子名称: | Importin subunit alpha-1, Protein W | | 著者 | Smith, K.M, Tsimbalyuk, S, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | | 登録日 | 2017-12-14 | | 公開日 | 2018-07-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
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8GSJ
 | | APC-Asef tripeptide inhibitor | | 分子名称: | (1R,2S)-2-phenylcyclopropanamine, 2-methylsulfanylpyrimidine-4-carbaldehyde, Adenomatous polyposis coli protein, ... | | 著者 | Zhang, J, Wang, X.F, Song, K. | | 登録日 | 2022-09-06 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | APC-Asef tripeptide inhibitor
To Be Published
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5FC8
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1G3J
 | | CRYSTAL STRUCTURE OF THE XTCF3-CBD/BETA-CATENIN ARMADILLO REPEAT COMPLEX | | 分子名称: | BETA-CATENIN ARMADILLO REPEAT REGION, TCF3-CBD (CATENIN BINDING DOMAIN) | | 著者 | Graham, T.A, Weaver, C, Mao, F, Kimelman, D, Xu, W. | | 登録日 | 2000-10-24 | | 公開日 | 2000-12-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of a beta-catenin/Tcf complex.
Cell(Cambridge,Mass.), 103, 2000
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3ZIO
 | | minor-site specific NLS (A28) | | 分子名称: | A28NLS, IMPORTIN SUBUNIT ALPHA-2 | | 著者 | Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. | | 登録日 | 2013-01-10 | | 公開日 | 2013-08-21 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha
Traffic, 14, 2013
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3AU3
 | | Crystal structure of armadillo repeat domain of APC | | 分子名称: | Adenomatous polyposis coli protein | | 著者 | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2011-01-28 | | 公開日 | 2011-11-02 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structures of the armadillo repeat domain of adenomatous polyposis coli and its complex with the tyrosine-rich domain of sam68
Structure, 19, 2011
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2YNS
 | | rImp_alpha_B54NLS | | 分子名称: | B54NLS, IMPORTIN SUBUNIT ALPHA-1A | | 著者 | Chang, C.-W, Counago, R.L.M, Williams, S.J, Boden, M, Kobe, B. | | 登録日 | 2012-10-18 | | 公開日 | 2013-01-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals.
Plant Cell, 24, 2012
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4YJL
 | | Crystal structure of APC-ARM in complexed with Amer1-A2 | | 分子名称: | 1,2-ETHANEDIOL, APC membrane recruitment protein 1, Adenomatous polyposis coli protein | | 著者 | Zhang, Z, Xiao, Y, Wu, G. | | 登録日 | 2015-03-03 | | 公開日 | 2016-03-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Cell Discov, 1, 2015
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1T08
 | | Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 | | 分子名称: | Adenomatous polyposis coli protein, Beta-catenin, Beta-catenin-interacting protein 1 | | 著者 | Ha, N.-C, Tonozuka, T, Stamos, J.L, Weis, W.I. | | 登録日 | 2004-04-07 | | 公開日 | 2004-10-12 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
Mol.Cell, 15, 2004
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3UKW
 | | Mouse importin alpha: Bimax1 peptide complex | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bimax1 peptide, Importin subunit alpha-2 | | 著者 | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | | 登録日 | 2011-11-10 | | 公開日 | 2012-10-03 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha
Traffic, 13, 2012
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7YCJ
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4U5S
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | 分子名称: | Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide | | 著者 | Stewart, M, Valkov, E, Holvey, R.S. | | 登録日 | 2014-07-25 | | 公開日 | 2015-05-13 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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7RG5
 | | Importin alpha3 in complex with p50 NLS | | 分子名称: | Importin subunit alpha-3, Isoform 3 of Nuclear factor NF-kappa-B p105 subunit | | 著者 | Smith, K.M, Tsimbalyuk, S, Aragao, D, Forwood, J.K. | | 登録日 | 2021-07-14 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | MERS-CoV ORF4b employs an unusual binding mechanism to target IMP alpha and block innate immunity.
Nat Commun, 13, 2022
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5X8N
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8TUR
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5IZ6
 | | Protein-protein interaction | | 分子名称: | Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, PHQ-ALA-GLY-GLU-ALA-LEU-TYR-GLU-NH2, ... | | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | | 登録日 | 2016-03-25 | | 公開日 | 2017-07-05 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Nat. Chem. Biol., 13, 2017
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6WBC
 | | Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex | | 分子名称: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | 著者 | de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | | 登録日 | 2020-03-26 | | 公開日 | 2021-07-07 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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5V5P
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6P6A
 | | Structure of Mouse Importin alpha - NIT2 NLS peptide complex | | 分子名称: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | | 著者 | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | | 登録日 | 2019-06-03 | | 公開日 | 2020-01-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.151 Å) | | 主引用文献 | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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