6WBC

Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex

Summary for 6WBC

Entry DOI	10.2210/pdb6wbc/pdb
Descriptor	Importin subunit alpha-1, DNA mismatch repair protein Mlh1 (3 entities in total)
Functional Keywords	importin alpha, nuclear import, nls, mlh1, protein transport, protein transport-nuclear protein complex, protein transport/nuclear protein
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	2
Total formula weight	51245.12
Authors	de Barros, A.C.,da Silva, T.D.,Oliveira, H.C.,Fukuda, C.A.,Fontes, M.R.M. (deposition date: 2020-03-26, release date: 2021-07-07, Last modification date: 2023-10-18)
Primary citation	de Oliveira, H.C.,da Silva, T.D.,Salvador, G.H.M.,Moraes, I.R.,Fukuda, C.A.,de Barros, A.C.,Fontes, M.R.M. Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochem.J., 478:2715-2732, 2021 Cited by PubMed: 34195786 DOI: 10.1042/BCJ20210401 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation