Structure of importin-alpha: dUTPase NLS complex

Replaces:  4FDR

Summary for 4MZ5

Related1ELJ 3UKW 4MZ6
DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1 (3 entities in total)
Functional Keywordsarm repeat, protein transport, importin, nucleus
Biological sourceMus musculus (mouse)
Cellular locationCytoplasm (By similarity) P33316
Isoform 2: Nucleus. Isoform 3: Mitochondrion P52293
Total number of polymer chains3
Total molecular weight57890.51
Marfori, M.,Rona, G.,Vertessy, B.G.,Kobe, B. (deposition date: 2013-09-29, release date: 2013-11-13, Last modification date: 2014-09-24)
Primary citation
Rona, G.,Marfori, M.,Borsos, M.,Scheer, I.,Takacs, E.,Toth, J.,Babos, F.,Magyar, A.,Erdei, A.,Bozoky, Z.,Buday, L.,Kobe, B.,Vertessy, B.G.
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Acta Crystallogr.,Sect.D, 69:2495-2505, 2013
PubMed: 24311590 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444913023354
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.222601.3%10.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report