4MZ6

Structure of importin-alpha: dUTPase S11E NLS mutant complex

Replaces:  4FDS

Summary for 4MZ6

Related1ELJ 3UKW 4MZ5
DescriptorDeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Importin subunit alpha-1 (3 entities in total)
Functional Keywordsarm repeat, protein transport, importin, nucleus
Biological sourceMus musculus (mouse)
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Cellular locationCytoplasm (By similarity) P33316
Isoform 2: Nucleus. Isoform 3: Mitochondrion P52293
Total number of polymer chains3
Total molecular weight57974.58
Authors
Marfori, M.,Rona, G.,Vertessy, B.G.,Kobe, B. (deposition date: 2013-09-29, release date: 2013-11-13, Last modification date: 2014-09-24)
Primary citation
Rona, G.,Marfori, M.,Borsos, M.,Scheer, I.,Takacs, E.,Toth, J.,Babos, F.,Magyar, A.,Erdei, A.,Bozoky, Z.,Buday, L.,Kobe, B.,Vertessy, B.G.
Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights.
Acta Crystallogr.,Sect.D, 69:2495-2505, 2013
PubMed: 24311590 (PDB entries with the same primary citation)
DOI: 10.1107/S0907444913023354
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.88 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.188303.0%8.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution