PDB: 292 件ウェブページステータス検索Chemie searchBIRD

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4ZDU	Crystal structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein 分子名称: Importin subunit alpha-1, Peptide from Nucleoprotein 著者 Nakada, R, Hirano, H, Matsuura, Y. 登録日 2015-04-19 公開日 2015-10-21 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of importin-alpha bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein Sci Rep, 5, 2015
7CRU	hnRNPK NLS in complex with Importin alpha 1 (KPNA2) 分子名称: ACETATE ION, GLYCEROL, Heterogeneous nuclear ribonucleoprotein K, ... 著者 Yao, J, Sun, Q. 登録日 2020-08-14 公開日 2021-11-17 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Nuclear import receptors and hnRNPK mediates nuclear import and stress granule localization of SIRLOIN. Cell.Mol.Life Sci., 78, 2021
8QXX	HCMV DNA polymerase processivity factor UL44 phosphorylated NLS 410-433 bound to mouse importin alpha 2 分子名称: DNA polymerase processivity factor, Importin subunit alpha-1 著者 Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. 登録日 2023-10-25 公開日 2023-11-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
8QXW	HCMV DNA polymerase processivity factor UL44 unphosphorylated NLS 410-433 bound to mouse importin alpha 2 分子名称: DNA polymerase processivity factor, Importin subunit alpha-1 著者 Cross, E.M, Marin, O, Ariawan, D, Aragao, D, Cozza, G, Di Iorio, E, Forwood, J.K, Alvisi, G. 登録日 2023-10-25 公開日 2023-11-08 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural determinants of phosphorylation-dependent nuclear transport of HCMV DNA polymerase processivity factor UL44. Febs Lett., 598, 2024
8Q8K	KI Polyomavirus LTA NLS bound to importin alpha 2 分子名称: Importin subunit alpha-1, Large T antigen 著者 Cross, E.M, Forwood, J.K, Alvisi, G. 登録日 2023-08-18 公開日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin alpha-dependent nuclear localization signals. Protein Sci., 33, 2024
8SG7	Adeno-Associated Virus Bat origin capsid protein basic regions in complex with importin-alpha 2 分子名称: Importin subunit alpha-1, VP1 capsid 著者 Hoad, M, Forwood, J.K. 登録日 2023-04-11 公開日 2023-07-19 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for nuclear import of bat adeno-associated virus capsid protein. J.Gen.Virol., 105, 2024
5CTT	Crystal structure of human SART3/TIP110 NLS-mouse importin alpha complex 分子名称: Importin subunit alpha-1, Squamous cell carcinoma antigen recognized by T-cells 3 著者 Park, J.K, Kim, E.E. 登録日 2015-07-24 公開日 2016-04-27 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural basis for recruiting and shuttling of the spliceosomal deubiquitinase USP4 by SART3 Nucleic Acids Res., 44, 2016
7F6M	Crystal structure of APC complexed with a peptide inhibitor MAI-516 分子名称: Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Song, K, Zhang, J. 登録日 2021-06-25 公開日 2022-06-29 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Discovery of Efficient Adenomatous Polyposis Coli - Rho Guanine Nucleotide Exchange Factor 4 Inhibitors by Employing High Binding Affinity Tracer To Be Published
7F7O	APC-Asef FP assay tracer 分子名称: Adenomatous polyposis coli protein, N-[3',6'-bis(oxidanyl)-3-oxidanylidene-spiro[2-benzofuran-1,9'-xanthene]-5-yl]methanethioamide, Tracer 7 著者 Yang, X, Zhang, J. 登録日 2021-06-30 公開日 2022-07-06 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The tracer of FP assay for screening APC-Asef inhbitors To Be Published
7M60	Structure of Mouse Importin alpha MLH1-S467A NLS Peptide Complex 分子名称: DNA mismatch repair protein Mlh1 NLS peptide, Importin subunit alpha-1 著者 De Oliveira, H.C, Da Silva, T.D, Fukuda, C.A, Fontes, M.R.M. 登録日 2021-03-25 公開日 2021-07-07 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha. Biochem.J., 478, 2021
7LFC	Structure of importin a3 bound to p50 NLS 分子名称: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit 著者 Florio, T.J, Lokareddy, R.K, Cingolani, G. 登録日 2021-01-16 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LF4	Structure of importin a3 bound to the p50- and p65-NLSs 分子名称: Importin subunit alpha-3, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 著者 Florio, T.J, Lokareddy, R.K, Cingolani, G. 登録日 2021-01-15 公開日 2022-01-19 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LEU	Structure of importin a2 bound to p65-NLS 分子名称: Importin subunit alpha-1, Transcription factor p65 著者 Florio, T.J, Lokareddy, R.K, Cingolani, G. 登録日 2021-01-15 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LET	Structure of importin a2 bound to the p50- and p65-NLSs 分子名称: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit, Transcription factor p65 著者 Florio, T.J, Lokareddy, R.K, Cingolani, G. 登録日 2021-01-15 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
7LEQ	Structure of importin a2 bound to p50 NLS 分子名称: Importin subunit alpha-1, Nuclear factor NF-kappa-B p105 subunit 著者 Florio, T.J, Lokareddy, R.K, Cingolani, G. 登録日 2021-01-14 公開日 2022-01-19 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.24 Å) 主引用文献 Differential recognition of canonical NF-kappa B dimers by Importin alpha 3. Nat Commun, 13, 2022
6IWA	Crystal structure of Importin-alpha and phosphoserine GM130 分子名称: Importin subunit alpha-1, PHOSPHOSERINE GM130 著者 Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C. 登録日 2018-12-05 公開日 2019-10-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Nat Commun, 10, 2019
6IUA	Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D) 分子名称: Importin subunit alpha-1, Peptide from TP53-binding protein 1 著者 Matsuura, Y. 登録日 2018-11-27 公開日 2019-01-30 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural and biochemical characterization of the recognition of the 53BP1 nuclear localization signal by importin-alpha. Biochem. Biophys. Res. Commun., 510, 2019
6IW8	Crystal structure of Importin-alpha and wild-type GM130 分子名称: Importin subunit alpha-1, Peptide from Golgin subfamily A member 2 著者 Chang, C.-C, Chen, C.-J, Pien, Y.-C, Tsai, S.-Y, Hsia, K.-C. 登録日 2018-12-04 公開日 2019-10-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Ran pathway-independent regulation of mitotic Golgi disassembly by Importin-alpha. Nat Commun, 10, 2019
7N8J	Human importin alpha 1 in complex with Bimax2 peptide 分子名称: BIMAX2, Importin subunit alpha-1 著者 Donnelly, C.M, Cross, E.M, Tsimbalyuk, S, Forwood, J.K. 登録日 2021-06-15 公開日 2021-06-30 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Human importin alpha 1:Bimax2 peptide complex To Be Published
7JJL	Crystal structure of Importin Alpha 3 in complex with human LSD1 NLS 分子名称: Importin subunit alpha-3, Lysine-specific histone demethylase 1A 著者 Tu, W.J, McCuaig, R, Tan, H.Y.A, Hardy, K, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. 登録日 2020-07-27 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020
7JK7	Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant 分子名称: GLYCEROL, Importin subunit alpha-1, Lysine-specific histone demethylase 1A 著者 Tu, W.J, McCuaig, R, Tan, A.H.Y, Hardy, K, Seddiki, N, Ali, S, Dahlstron, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. 登録日 2020-07-27 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020
7L04	Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2 分子名称: Importin subunit alpha-1, VP1 著者 Hoad, M, Forwood, J. 登録日 2020-12-11 公開日 2021-02-24 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.26 Å) 主引用文献 Crystal Structure of Adeno-Associated Virus Porcine Origin capsid protein in complex with Importin-alpha 2 To Be Published
7N9H	Structure of the mammalian importin a1 bound to the TDP-43 NLS 分子名称: Importin subunit alpha-1, TAR DNA-binding protein 43 著者 Doll, S.G, Lokareddy, R.K, Cingolani, G. 登録日 2021-06-17 公開日 2022-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Recognition of the TDP-43 nuclear localization signal by importin alpha 1/ beta. Cell Rep, 39, 2022
7JVO	Importin alpha bound to the C-terminus of ACE2 分子名称: ARG-LYS-LYS-LYS-ASN-LYS-ALA, Importin subunit alpha-1 著者 Forwood, J.K, Cross, E.M, Tsimbalyuk, S. 登録日 2020-08-22 公開日 2020-10-14 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Targeting novel LSD1-dependent ACE2 demethylation domains inhibits SARS-CoV-2 replication. Cell Discov, 7, 2021
7JJM	Crystal structure of Importin alpha 2 in complex with LSD1 NLS 分子名称: CHLORIDE ION, Importin subunit alpha-1, Lysine-specific histone demethylase 1A 著者 Tu, W.J, McGuaig, R, Tan, H.Y.A, Hardy, C, Seddiki, N, Ali, S, Dahlstrom, J.E, Bean, E.G, Dunn, J, Forwood, J.K, Tsimbalyuk, S, Smith, K.M, Yip, D, Malik, L, Prasana, T, Milburn, P, Rao, S. 登録日 2020-07-27 公開日 2020-08-05 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Targeting Nuclear LSD1 to Reprogram Cancer Cells and Reinvigorate Exhausted T Cells via a Novel LSD1-EOMES Switch. Front Immunol, 11, 2020

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