PDB: 109 件ウェブページステータス検索Chemie searchBIRD

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7WTC	Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... 著者 Chai, P, Lan, P, Wu, J, Lei, M. 登録日 2022-02-04 公開日 2022-11-09 最終更新日 2022-11-16 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA. Mol.Cell, 82, 2022
3GLK	The biotin carboxylase (BC) domain of human Acetyl-CoA Carboxylase 2 (ACC2) 分子名称: Acetyl-CoA carboxylase 2 著者 Price, A, Kulathila, R. 登録日 2009-03-12 公開日 2009-03-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Synthesis and characterization of a BODIPY-labeled derivative of Soraphen A that binds to acetyl-CoA carboxylase. Bioorg.Med.Chem.Lett., 19, 2009
3HBL	Crystal Structure of S. aureus Pyruvate Carboxylase T908A Mutant 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Tong, L, Yu, L.P.C. 登録日 2009-05-04 公開日 2009-06-30 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2.71 Å) 主引用文献 A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3HB9	Crystal Structure of S. aureus Pyruvate Carboxylase A610T Mutant 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ADENOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Tong, L, Yu, L.P.C. 登録日 2009-05-04 公開日 2009-06-30 最終更新日 2021-10-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3JZF	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazoles series 分子名称: 2-[(2-chlorobenzyl)amino]-1-(cyclohexylmethyl)-1H-benzimidazole-5-carboxamide, Biotin carboxylase, CARBONATE ION 著者 Orth, P. 登録日 2009-09-23 公開日 2009-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3HO8	Crystal Structure of S. aureus Pyruvate Carboxylase in complex with Coenzyme A 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, MANGANESE (II) ION, ... 著者 Tong, L, Yu, L.P.C. 登録日 2009-06-01 公開日 2009-06-30 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, 17, 2009
3JZI	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series 分子名称: 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide, Biotin carboxylase 著者 Cheng, C, Shipps, G.W, Yang, Z, Sun, B, Kawahata, N, Soucy, K, Soriano, A, Orth, P, Xiao, L, Mann, P, Black, T. 登録日 2009-09-23 公開日 2009-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
3JRW	Phosphorylated BC domain of ACC2 分子名称: Acetyl-CoA carboxylase 2 著者 Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. 登録日 2009-09-09 公開日 2010-01-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK Biochem.Biophys.Res.Commun., 391, 2010
3JRX	Crystal structure of the BC domain of ACC2 in complex with soraphen A 分子名称: Acetyl-CoA carboxylase 2, SORAPHEN A 著者 Cho, Y.S, Lee, J.I, Shin, D, Kim, H.T, Lee, T.G, Heo, Y.S. 登録日 2009-09-09 公開日 2010-01-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK. Biochem.Biophys.Res.Commun., 391, 2010
8HZ4	The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate 分子名称: Biotin carboxylase 著者 Shen, J, Wu, W, Xu, X. 登録日 2023-01-08 公開日 2024-01-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 The tetrameric structure of biotin carboxylase from Chloroflexus aurantiacus in complex with bicarbonate To be published
8HZ5	The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus 分子名称: Biotin carboxylase 著者 Shen, J, Wu, W, Xu, X. 登録日 2023-01-08 公開日 2024-01-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The homodimer of a biotin carboxylase isoform from chloroflexus aurantiacus To be published
8J7O	Human pyruvate carboxylase in BCCP-CTS state without BC 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial 著者 Liu, D.S, Su, J.Y. 登録日 2023-04-27 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.83 Å) 主引用文献 Human pyruvate carboxylase To Be Published
8J4Z	Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-04-21 公開日 2024-04-24 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCCP-CTS state with substrate To Be Published
8J7D	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-04-27 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state To Be Published
8J99	Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state 分子名称: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, Methylcrotonoyl-CoA carboxylase subunit alpha, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-05-02 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCS-mcoa state To Be Published
8J78	Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y. 登録日 2023-04-27 公開日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.88 Å) 主引用文献 Human 3-methylcrotonyl-CoA carboxylase in BCCP-H2 state To Be Published
8JAW	Human MCC in MCCD state 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y, Tian, X.Y. 登録日 2023-05-07 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.51 Å) 主引用文献 Human MCC in BCCP-CTS state To Be Published
8JAK	Human MCC in MCCU state 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial, ... 著者 Liu, D.S, Su, J.Y, Tian, X.Y. 登録日 2023-05-06 公開日 2024-05-15 実験手法 ELECTRON MICROSCOPY (2.52 Å) 主引用文献 Human MCC in BCCP-BCS state To Be Published
8PN7	Engineered glycolyl-CoA carboxylase (G20R variant) with bound CoA 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... 著者 Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. 登録日 2023-06-30 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.03 Å) 主引用文献 Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase. Acs Synth Biol, 12, 2023
8PN8	Engineered glycolyl-CoA carboxylase (L100N variant) with bound CoA 分子名称: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Propionyl-CoA carboxylase alpha subunit, ... 著者 Zarzycki, J, Marchal, D.G, Schulz, L, Prinz, S, Erb, T.J. 登録日 2023-06-30 公開日 2023-11-29 最終更新日 2023-12-27 実験手法 ELECTRON MICROSCOPY (2.31 Å) 主引用文献 Machine Learning-Supported Enzyme Engineering toward Improved CO 2 -Fixation of Glycolyl-CoA Carboxylase. Acs Synth Biol, 12, 2023
2V59	CRYSTAL STRUCTURE OF BIOTIN CARBOXYLASE FROM E.COLI IN COMPLEX WITH POTENT INHIBITOR 2 分子名称: 6-(2,6-DIMETHOXYPHENYL)PYRIDO[2,3-D]PYRIMIDINE-2,7-DIAMINE, BIOTIN CARBOXYLASE 著者 Mochalkin, I, Miller, J.R. 登録日 2008-10-02 公開日 2009-01-13 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Class of Selective Antibacterials Derived from a Protein Kinase Inhibitor Pharmacophore. Proc.Natl.Acad.Sci.USA, 106, 2009
2VQD	Crystal Structure of Biotin Carboxylase from Pseudomonas aeruginosa complexed with AMPCP 分子名称: BIOTIN CARBOXYLASE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... 著者 Mochalkin, I. 登録日 2008-03-13 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
2W6O	Crystal structure of Biotin carboxylase from E. coli in complex with 4-Amino-7,7-dimethyl-7,8-dihydro-quinazolinone fragment 分子名称: 4-amino-7,7-dimethyl-7,8-dihydroquinazolin-5(6H)-one, BIOTIN CARBOXYLASE, CHLORIDE ION 著者 Mochalkin, I, Miller, J.R. 登録日 2008-12-18 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009
2VPQ	Crystal structure of biotin carboxylase from S. aureus complexed with AMPPNP 分子名称: ACETYL-COA CARBOXYLASE, CHLORIDE ION, MAGNESIUM ION, ... 著者 Mochalkin, I. 登録日 2008-03-03 公開日 2008-09-09 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural Evidence for Substrate-Induced Synergism and Half-Sites Reactivity in Biotin Carboxylase. Protein Sci., 17, 2008
2W6M	Crystal structure of Biotin carboxylase from E. coli in complex with amino-oxazole fragment series 分子名称: (2-AMINO-1,3-OXAZOL-5-YL)-(3-BROMOPHENYL)METHANONE, BIOTIN CARBOXYLASE, CHLORIDE ION 著者 Mochalkin, I, Miller, J.R. 登録日 2008-12-18 公開日 2009-05-19 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Antibacterial Biotin Carboxylase Inhibitors by Virtual Screening and Fragment-Based Approaches. Acs Chem.Biol., 4, 2009

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