5L19
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![BU of 5l19 by Molmil](/molmil-images/mine/5l19) | |
5L36
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![BU of 5l36 by Molmil](/molmil-images/mine/5l36) | |
5CIR
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![BU of 5cir by Molmil](/molmil-images/mine/5cir) | |
5MU8
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![BU of 5mu8 by Molmil](/molmil-images/mine/5mu8) | HUMAN TNF-ALPHA IN COMPLEX WITH JNJ525 | 分子名称: | Tumor necrosis factor, ~{N}4-(phenylmethyl)-~{N}4-[2-[3-(2-piperazin-1-ylpyrimidin-5-yl)phenyl]phenyl]pyrimidine-2,4-diamine | 著者 | Blevitt, J.M, Hack, M.D, Herman, K.L, Jackson, P.F, Krawczuk, P.J, Lebsack, A.D, Liu, A.X, Mirzadegan, T, Nelen, M.I, Patrick, A.P, Steinbacher, S, Milla, M.E, Lumb, K.J. | 登録日 | 2017-01-12 | 公開日 | 2017-03-29 | 最終更新日 | 2019-02-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. J. Med. Chem., 60, 2017
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5WUX
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![BU of 5wux by Molmil](/molmil-images/mine/5wux) | TNFalpha-certolizumab Fab | 分子名称: | Tumor necrosis factor alpha, heavy, light | 著者 | Heo, Y.S, Lee, J.U. | 登録日 | 2016-12-21 | 公開日 | 2017-06-07 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Molecular Basis for the Neutralization of Tumor Necrosis Factor alpha by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases Int J Mol Sci, 18, 2017
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5UUI
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![BU of 5uui by Molmil](/molmil-images/mine/5uui) | Crystal Structure of Spin-Labeled T77C TNFa | 分子名称: | S-[(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate, Tumor necrosis factor | 著者 | Horanyi, P.S, Dranow, D.M, Ceska, T. | 登録日 | 2017-02-16 | 公開日 | 2017-08-02 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Natural Conformational Sampling of Human TNF alpha Visualized by Double Electron-Electron Resonance. Biophys. J., 113, 2017
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5M2I
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![BU of 5m2i by Molmil](/molmil-images/mine/5m2i) | Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 | 分子名称: | Tumor necrosis factor, VHH1 | 著者 | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | 登録日 | 2016-10-13 | 公開日 | 2017-08-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
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5M2J
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![BU of 5m2j by Molmil](/molmil-images/mine/5m2j) | Complex between human TNF alpha and Llama VHH2 | 分子名称: | Anti-(ED-B) scFV, Tumor necrosis factor | 著者 | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | 登録日 | 2016-10-13 | 公開日 | 2017-08-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
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5M2M
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![BU of 5m2m by Molmil](/molmil-images/mine/5m2m) | Complex between human TNF alpha and Llama VHH3 | 分子名称: | Llama nanobody VHH3, Tumor necrosis factor | 著者 | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | 登録日 | 2016-10-13 | 公開日 | 2017-08-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions. Front Immunol, 8, 2017
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5Y9J
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![BU of 5y9j by Molmil](/molmil-images/mine/5y9j) | BAFF in complex with belimumab | 分子名称: | Tumor necrosis factor ligand superfamily member 13B, belibumab light chain, belimumab heavy chain | 著者 | Heo, Y.-S, Shin, W. | 登録日 | 2017-08-25 | 公開日 | 2018-02-21 | 最終更新日 | 2019-09-04 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus. Nat Commun, 9, 2018
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6FXN
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![BU of 6fxn by Molmil](/molmil-images/mine/6fxn) | Crystal structure of human BAFF in complex with Fab fragment of anti-BAFF antibody belimumab | 分子名称: | Tumor necrosis factor ligand superfamily member 13B, belimumab heavy chain, belimumab light chain | 著者 | Lammens, A, Maskos, K, Willen, L, Jiang, X, Schneider, P. | 登録日 | 2018-03-09 | 公開日 | 2018-04-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors. Nat Commun, 9, 2018
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5YOY
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![BU of 5yoy by Molmil](/molmil-images/mine/5yoy) | Crystal structure of the human tumor necrosis factor in complex with golimumab Fv | 分子名称: | Golimumab heavy chain variable region, Golimumab light chain variable region, Tumor necrosis factor | 著者 | Ono, M, Horita, S, Sato, Y, Nomura, Y, Iwata, S, Nomura, N. | 登録日 | 2017-10-31 | 公開日 | 2018-05-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.727 Å) | 主引用文献 | Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab Protein Sci., 27, 2018
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6D3N
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![BU of 6d3n by Molmil](/molmil-images/mine/6d3n) | Crystal structure of h4-1BB ligand | 分子名称: | GLYCEROL, Tumor necrosis factor ligand superfamily member 9 | 著者 | Aruna, B, Zajonc, D.M, Doukov, T. | 登録日 | 2018-04-16 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
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6CPR
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![BU of 6cpr by Molmil](/molmil-images/mine/6cpr) | Crystal structure of 4-1BBL/4-1BB complex in C2 space group | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | 著者 | Aruna, B, Zajonc, D.M. | 登録日 | 2018-03-14 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
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6BWV
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![BU of 6bwv by Molmil](/molmil-images/mine/6bwv) | |
6CU0
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![BU of 6cu0 by Molmil](/molmil-images/mine/6cu0) | Crystal structure of 4-1BBL/4-1BB (C121S) complex in P21 space group | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | 著者 | Aruna, B, Zajonc, D.M, Doukov, T. | 登録日 | 2018-03-23 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structures of the human 4-1BB receptor bound to its ligand 4-1BBL reveal covalent receptor dimerization as a potential signaling amplifier. J. Biol. Chem., 293, 2018
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6A3V
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![BU of 6a3v by Molmil](/molmil-images/mine/6a3v) | Complex structure of human 4-1BB and 4-1BBL | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | 著者 | Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | 登録日 | 2018-06-17 | 公開日 | 2018-10-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.391 Å) | 主引用文献 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab. Cell Rep, 25, 2018
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6MGP
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![BU of 6mgp by Molmil](/molmil-images/mine/6mgp) | Structure of human 4-1BB / 4-1BBL complex | 分子名称: | ACETATE ION, GLYCEROL, Tumor necrosis factor ligand superfamily member 9, ... | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | 登録日 | 2018-09-14 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab Nat Commun, 9, 2018
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6MGE
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![BU of 6mge by Molmil](/molmil-images/mine/6mge) | Structure of human 4-1BBL | 分子名称: | GLYCEROL, PHOSPHATE ION, Tumor necrosis factor ligand superfamily member 9 | 著者 | Kimberlin, C.R, Chin, S.M, Roe-Zurz, Z, Xu, A, Yang, Y. | 登録日 | 2018-09-13 | 公開日 | 2018-11-21 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab. Nat Commun, 9, 2018
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6BRB
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![BU of 6brb by Molmil](/molmil-images/mine/6brb) | Novel non-antibody protein scaffold targeting CD40L | 分子名称: | CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. | 登録日 | 2017-11-30 | 公開日 | 2018-12-05 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.82 Å) | 主引用文献 | A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11, 2019
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6MKB
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![BU of 6mkb by Molmil](/molmil-images/mine/6mkb) | Crystal structure of murine 4-1BB ligand | 分子名称: | SODIUM ION, SULFATE ION, Tumor necrosis factor ligand superfamily member 9, ... | 著者 | Bitra, A, Zajonc, D.M, Doukov, T. | 登録日 | 2018-09-25 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding. J. Biol. Chem., 294, 2019
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6MKZ
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![BU of 6mkz by Molmil](/molmil-images/mine/6mkz) | Crystal structure of murine 4-1BB/4-1BBL complex | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Bitra, A, Zajonc, D.M, Doukov, T. | 登録日 | 2018-09-26 | 公開日 | 2018-12-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding. J. Biol. Chem., 294, 2019
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6FIB
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![BU of 6fib by Molmil](/molmil-images/mine/6fib) | Structure of human 4-1BB ligand | 分子名称: | Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor ligand superfamily member 9,4-1BBL -CH/CL fusion, Tumor necrosis factor ligand superfamily member 9,Uncharacterized protein | 著者 | Joseph, C, Claus, C, Ferrara, C, von Hirschheydt, T, Prince, C, Funk, D, Klein, C, Benz, J. | 登録日 | 2018-01-17 | 公開日 | 2019-03-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy. Sci Transl Med, 11, 2019
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6I50
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![BU of 6i50 by Molmil](/molmil-images/mine/6i50) | |
6RMJ
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![BU of 6rmj by Molmil](/molmil-images/mine/6rmj) | Crystal structure of human NGR-TNF | 分子名称: | Tumor necrosis factor | 著者 | Degano, M, Garau, G. | 登録日 | 2019-05-07 | 公開日 | 2019-10-09 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Mechanism of Action of the Tumor Vessel Targeting Agent NGR-hTNF: Role of Both NGR Peptide and hTNF in Cell Binding and Signaling. Int J Mol Sci, 20, 2019
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