PDB: 377 件ウェブページステータス検索Chemie searchBIRD

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6ZK6	Protein Phosphatase 1 (PP1) T320E mutant 分子名称: FE (III) ION, MANGANESE (II) ION, PHOSPHATE ION, ... 著者 Salvi, F, Barabas, O, Koehn, M. 登録日 2020-06-29 公開日 2020-11-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Towards Dissecting the Mechanism of Protein Phosphatase-1 Inhibition by Its C-Terminal Phosphorylation. Chembiochem, 22, 2021
6CZO	The KNL1-PP1 Holoenzyme 分子名称: CASC5 protein, MANGANESE (II) ION, PHOSPHATE ION, ... 著者 Bajaj, R, Peti, W, Page, R. 登録日 2018-04-09 公開日 2019-01-23 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.95 Å) 主引用文献 KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive. Structure, 26, 2018
3N5U	Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1 分子名称: CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ... 著者 Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M. 登録日 2010-05-25 公開日 2010-08-11 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein. Nat.Struct.Mol.Biol., 17, 2010
5W0W	Crystal structure of Protein Phosphatase 2A bound to TIPRL 分子名称: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ... 著者 Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y. 登録日 2017-06-01 公開日 2018-01-17 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 Methylation-regulated decommissioning of multimeric PP2A complexes. Nat Commun, 8, 2017
1KBP	KIDNEY BEAN PURPLE ACID PHOSPHATASE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PURPLE ACID PHOSPHATASE, ... 著者 Klabunde, T, Strater, N, Krebs, B. 登録日 1995-02-20 公開日 1996-10-14 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures. J.Mol.Biol., 259, 1996
6NUC	Structure of Calcineurin in complex with NHE1 peptide 分子名称: CALCIUM ION, Calcineurin subunit B type 1, DI(HYDROXYETHYL)ETHER, ... 著者 Wang, X, Page, R, Peti, W. 登録日 2019-01-31 公開日 2019-07-03 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Molecular basis for the binding and selective dephosphorylation of Na+/H+exchanger 1 by calcineurin. Nat Commun, 10, 2019
1AUI	HUMAN CALCINEURIN HETERODIMER 分子名称: CALCIUM ION, FE (III) ION, SERINE/THREONINE PHOSPHATASE 2B, ... 著者 Kissinger, C.R, Parge, H.E, Knighton, D.R, Pelletier, L.A, Lewis, C.T, Tempczyk, A, Villafranca, J.E. 登録日 1997-08-27 公開日 1997-12-03 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. Nature, 378, 1995
5EBE	Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with 5' CMP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-O-phosphono-beta-D-ribofuranose, ... 著者 Lim, S.M, Yeung, K, Tresaugues, L, Teo, H.L, Nordlund, P. 登録日 2015-10-19 公開日 2016-01-20 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity. Febs J., 283, 2016
2IE3	Structure of the Protein Phosphatase 2A Core Enzyme Bound to Tumor-inducing Toxins 分子名称: MANGANESE (II) ION, Protein Phosphatase 2, regulatory subunit A (PR 65), ... 著者 Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y. 登録日 2006-09-17 公開日 2006-11-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins Cell(Cambridge,Mass.), 127, 2006
5WG8	Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density 分子名称: (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... 著者 D'Arcy, B.M, Swingle, M.R, Honkanen, R.E, Prakash, A. 登録日 2017-07-13 公開日 2018-07-18 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C. Mol. Cancer Ther., 18, 2019
7SOY	The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex 分子名称: Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ... 著者 Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y. 登録日 2021-11-01 公開日 2022-08-31 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition. Elife, 11, 2022
2IE4	Structure of the Protein Phosphatase 2A Core Enzyme Bound to okadaic acid 分子名称: MANGANESE (II) ION, OKADAIC ACID, Protein Phosphatase 2, ... 著者 Xing, Y, Xu, Y, Chen, Y, Jeffrey, P.D, Chao, Y, Shi, Y. 登録日 2006-09-17 公開日 2006-11-07 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins Cell(Cambridge,Mass.), 127, 2006
4V0V	The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-660) 分子名称: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT, ... 著者 Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. 登録日 2014-09-18 公開日 2015-03-25 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
4UT3	X-ray structure of the human PP1 gamma catalytic subunit treated with hydrogen peroxide 分子名称: MANGANESE (II) ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT 著者 Zeh Silva, M, Kopec, J, Fotinou, D, Steiner, R.A. 登録日 2014-07-17 公開日 2015-07-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling. Embo J., 35, 2016
4UT2	X-ray structure of the human PP1 gamma catalytic subunit treated with ascorbate 分子名称: MANGANESE (II) ION, PHOSPHATE ION, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT 著者 Kopec, J, Zeh Silva, M, Fotinou, C, Steiner, R.A. 登録日 2014-07-17 公開日 2015-07-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Targeted Redox Inhibition of Protein Phosphatase 1 by Nox4 Regulates Eif2Alpha-Mediated Stress Signaling. Embo J., 35, 2016
4Q7F	1.98 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with Adenosine. 分子名称: (2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-tetrahydro-2-(hydroxymethyl)furan-3-ol, 5' nucleotidase family protein, MAGNESIUM ION, ... 著者 Minasov, G, Nocadello, S, Shuvalova, L, Dubrovska, I, Winsor, J, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) 登録日 2014-04-24 公開日 2014-05-07 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 1.98 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with Adenosine. TO BE PUBLISHED
4V0X	The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-684) 分子名称: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT 著者 Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. 登録日 2014-09-18 公開日 2015-03-25 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
4V0W	The crystal structure of mouse PP1G in complex with truncated human PPP1R15B (631-669) 分子名称: MANGANESE (II) ION, PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 15B, SERINE/THREONINE-PROTEIN PHOSPHATASE PP1-GAMMA CATALYTIC SUBUNIT 著者 Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. 登録日 2014-09-18 公開日 2015-03-25 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
7K36	Cryo-EM structure of STRIPAK complex 分子名称: INOSITOL HEXAKISPHOSPHATE, MANGANESE (II) ION, MOB-like protein phocein, ... 著者 Jeong, B.-C, Bai, X.C. 登録日 2020-09-10 公開日 2021-03-10 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Cryo-EM structure of the Hippo signaling integrator human STRIPAK. Nat.Struct.Mol.Biol., 28, 2021
8DWL	Inhibitor-3:PP1 coexpressed complex 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase PPP1R11, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, ... 著者 Choy, M.S, Srivastava, G, Page, R, Peti, W. 登録日 2022-08-01 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction. Nat Commun, 14, 2023
8DWK	Inhibitor-3:PP1 reconstituted complex 分子名称: E3 ubiquitin-protein ligase PPP1R11, MANGANESE (II) ION, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 著者 Choy, M.S, Srivastava, G, Page, R, Peti, W. 登録日 2022-08-01 公開日 2023-02-15 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein-protein interaction. Nat Commun, 14, 2023
8DZK	Dbr1 in complex with 5-mer cleavage product 分子名称: FE (II) ION, RNA (5'-R(P*(G46)P*UP*GP*UP*U)-3'), RNA lariat debranching enzyme, ... 著者 Clark, N.E, Taylor, A.B. 登録日 2022-08-08 公開日 2022-08-24 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product. Biochemistry, 61, 2022
7JV9	Human CD73 (ecto 5'-nucleotidase) in complex with compound 12 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, 6-chloro-N-[(2-chlorophenyl)methyl]-1-[5-O-(phosphonomethyl)-beta-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine, ... 著者 Gibbons, P, Du, X. 登録日 2020-08-20 公開日 2020-09-23 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production. J.Med.Chem., 63, 2020
1M63	Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes 分子名称: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CYCLOSPORIN A, ... 著者 Huai, Q, Kim, H.-Y, Liu, Y, Zhao, Y, Mondragon, A, Liu, J.O, Ke, H. 登録日 2002-07-12 公開日 2002-09-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes Proc.Natl.Acad.Sci.USA, 99, 2002
1MF8	Crystal Structure of human calcineurin complexed with cyclosporin A and human cyclophilin 分子名称: CALCINEURIN B SUBUNIT ISOFORM 1, CALCIUM ION, CALMODULIN-DEPENDENT CALCINEURIN A SUBUNIT, ... 著者 Jin, L, Harrison, S.C. 登録日 2002-08-09 公開日 2002-10-16 最終更新日 2012-12-12 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Crystal Structure of Human Calcineurin Complexed with Cyclosporin a and Human Cyclophilin Proc.Natl.Acad.Sci.USA, 99, 2002

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