PDB: 2569 件ウェブページステータス検索Chemie searchBIRD

---

7BSA	Bovine Pancreatic Trypsin with 5-Chlorotryptamine (Cryo) 分子名称: 2-(5-chloranyl-1~{H}-indol-3-yl)ethanamine, CALCIUM ION, Cationic trypsin, ... 著者 Maeki, M, Ito, S, Takeda, R, Funakubo, T, Ueno, G, Ishida, A, Tani, H, Yamamoto, M, Tokeshi, M. 登録日 2020-03-30 公開日 2020-08-26 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.22 Å) 主引用文献 Room-temperature crystallography using a microfluidic protein crystal array device and its application to protein-ligand complex structure analysis. Chem Sci, 11, 2020
4X1N	The crystal structure of mupain-1-16 in complex with murinised human uPA at pH7.4 分子名称: Urokinase-type plasminogen activator, mupain-1-16, piperidine-1-carboximidamide 著者 Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. 登録日 2014-11-25 公開日 2015-03-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One, 9, 2014
4X6M	FACTOR XIA IN COMPLEX WITH THE INHIBITOR 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[2-(aminomethyl)-5-chlorobenzyl]urea 分子名称: 1,2-ETHANEDIOL, 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[2-(aminomethyl)-5-chlorobenzyl]urea, Coagulation factor XI, ... 著者 Wei, A. 登録日 2014-12-08 公開日 2015-02-18 最終更新日 2015-04-01 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg.Med.Chem.Lett., 25, 2015
4X6N	FACTOR XIA IN COMPLEX WITH THE INHIBITOR 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]urea 分子名称: 1,2-ETHANEDIOL, 1-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)benzyl]urea, Coagulation factor XI, ... 著者 Wei, A. 登録日 2014-12-08 公開日 2015-02-18 最終更新日 2015-04-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg.Med.Chem.Lett., 25, 2015
4X6O	FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl (4-{4-chloro-2-[(1S)-1-({3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]propanoyl}amino)-2-phenylethyl]-1H-imidazol-5-yl}phenyl)carbamate 分子名称: 1,2-ETHANEDIOL, Coagulation factor XI, light chain, ... 著者 Wei, A. 登録日 2014-12-08 公開日 2015-02-18 最終更新日 2015-04-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg.Med.Chem.Lett., 25, 2015
4WXI	FACTOR XIA IN COMPLEX WITH THE INHIBITOR trans-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)pyridin-2-yl]-2-phenylethyl}-4-(aminomethyl)cyclohexanecarboxamide 分子名称: 1,2-ETHANEDIOL, COAGULATION FACTOR XI, LIGHT CHAIN, ... 著者 Wei, A. 登録日 2014-11-13 公開日 2015-01-28 最終更新日 2018-08-29 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Pyridine and pyridinone-based factor XIa inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
4X1Q	The crystal structure of mupain-1 in complex with murinised human uPA at pH7.4 分子名称: Urokinase-type plasminogen activator, mupain-1 著者 Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. 登録日 2014-11-25 公開日 2015-03-25 最終更新日 2015-11-04 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One, 9, 2014
4X0W	The crystal structure of mupain-1-17 in complex with murinised human uPA 分子名称: SULFATE ION, Urokinase-type plasminogen activator, mupain-1-17, ... 著者 Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. 登録日 2014-11-24 公開日 2015-10-21 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int.J.Biochem.Cell Biol., 62, 2015
4X1P	The crystal structure of mupain-1-17 in complex with murinised human uPA at pH4.6 分子名称: MUPAIN-1-17, SULFATE ION, TRIETHYLENE GLYCOL, ... 著者 Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. 登録日 2014-11-25 公開日 2015-10-21 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. Int.J.Biochem.Cell Biol., 62, 2015
4X1S	The crystal structure of mupain-1-16-D9A in complex with murinised human uPA at pH7.4 分子名称: Urokinase-type plasminogen activator, mupain-1-16, piperidine-1-carboximidamide 著者 Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. 登録日 2014-11-25 公開日 2015-10-28 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One, 9, 2014
4WVP	Crystal structure of an activity-based probe HNE complex 分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BTN-3V3-NLB-OMT-OIC-3V2, ... 著者 Lechtenberg, B.C, Kasperkiewicz, P, Robinson, H.R, Drag, M, Riedl, S.J. 登録日 2014-11-06 公開日 2015-02-11 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 The Elastase-PK101 Structure: Mechanism of an Ultrasensitive Activity-based Probe Revealed. Acs Chem.Biol., 10, 2015
4X6P	FACTOR XIA (PICHIA PASTORIS; C500S [C122S]) IN COMPLEX WITH THE INHIBITOR (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide 分子名称: (2E)-N-{(1S)-1-[4-(3-amino-1H-indazol-6-yl)-1H-imidazol-2-yl]-2-phenylethyl}-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ... 著者 Sheriff, S. 登録日 2014-12-08 公開日 2015-02-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. Bioorg.Med.Chem.Lett., 25, 2015
4X1R	The crystal structure of mupain-1-12 in complex with murinised human uPA at pH7.4 分子名称: 1-phenylguanidine, Urokinase-type plasminogen activator, mupain-1-12 著者 Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. 登録日 2014-11-25 公開日 2015-03-25 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One, 9, 2014
4XE4	Coagulation Factor XII protease domain crystal structure 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XII, GLYCEROL 著者 Pathak, M, Wilmann, P, Awford, J, Li, C, Fisher, P.M, Dreveny, I, Dekker, L.V, Emsley, J. 登録日 2014-12-22 公開日 2015-02-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Coagulation factor XII protease domain crystal structure. J.Thromb.Haemost., 13, 2015
4XOJ	Structure of bovine trypsin in complex with analogues of sunflower inhibitor 1 (SFTI-1) 分子名称: 1,2-ETHANEDIOL, AMMONIUM ION, CALCIUM ION, ... 著者 Golik, P, Malicki, S, Grudnik, P, Karna, N, Debowski, D, Legowska, A, Wladyka, B, Gitlin, A, Brzozowski, K, Dubin, G, Rolka, K. 登録日 2015-01-16 公開日 2015-08-12 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (0.91 Å) 主引用文献 Investigation of Serine-Proteinase-Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI-1). Chembiochem, 16, 2015
4XDE	Coagulation Factor XII protease domain crystal structure 分子名称: CITRATE ANION, Coagulation factor XII, ISOPROPYL ALCOHOL 著者 Pathak, M, Wilmann, P, Awford, J, Li, C, Fisher, P.M, Dreveny, I, Dekker, L.V, Emsley, J. 登録日 2014-12-19 公開日 2015-02-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Coagulation factor XII protease domain crystal structure. J.Thromb.Haemost., 13, 2015
7CJ1	The crystal structure of FXIa serine protease domain in complex with benzamidine 分子名称: BENZAMIDINE, Coagulation factor XI 著者 Jiang, L, Huang, M. 登録日 2020-07-09 公開日 2022-04-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The crystal structure of FXIa serine protease domain in complex with benzamidine. To Be Published
7DZD	Crystal structure of uPA in complex with cleaved camostat 分子名称: 4-carbamimidamidobenzoic acid, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator 著者 Jiang, L.G, Huang, M.D. 登録日 2021-01-25 公開日 2021-07-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of uPA in complex with cleaved camostat To Be Published
7FBP	FXIIa-cMCoFx1 complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Coagulation factor XIIa light chain, cMCoFx1 著者 Sengoku, T, Liu, W, de Veer, S.J, Huang, Y.H, Okada, C, Zdenek, C.N, Fry, B.G, Swedberg, J.E, Passioura, T, Craik, D.J, Suga, H, Ogata, K. 登録日 2021-07-12 公開日 2021-11-10 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold. J.Am.Chem.Soc., 143, 2021
4TPY	High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density 分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, ... 著者 Teplitsky, E, Joshi, K, Mullen, J.D, Soares, A.S. 登録日 2014-06-10 公開日 2014-10-22 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 High throughput screening using acoustic droplet ejection to combine protein crystals and chemical libraries on crystallization plates at high density. J.Struct.Biol., 191, 2015
4SGA	STRUCTURES OF PRODUCT AND INHIBITOR COMPLEXES OF STREPTOMYCES GRISEUS PROTEASE A AT 1.8 ANGSTROMS RESOLUTION. A MODEL FOR SERINE PROTEASE CATALYSIS 分子名称: PROTEINASE A (SGPA), TETRAPEPTIDE ACE-PRO-ALA-PRO-PHE 著者 Sielecki, A.R, James, M.N.G. 登録日 1990-05-29 公開日 1991-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structures of product and inhibitor complexes of Streptomyces griseus protease A at 1.8 A resolution. A model for serine protease catalysis. J.Mol.Biol., 144, 1980
4TY7	Factor XIa in complex with the inhibitor (2S)-6-amino-N-{(1S)-1-[4-(3-amino-2H-indazol-6-yl)-5-chloro-1H-imidazol-2-yl]-2-phenylethyl}-2-ethylhexanamide 分子名称: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ... 著者 Wei, A. 登録日 2014-07-08 公開日 2014-12-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity. J.Med.Chem., 57, 2014
4TY6	Factor XIa in complex with the inhibitor 4-{2-[(1S)-1-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1H-imidazol-4-yl}benzamide 分子名称: 1,2-ETHANEDIOL, 4-{2-[(1S)-1-({[trans-4-(aminomethyl)cyclohexyl]carbonyl}amino)-2-phenylethyl]-1H-imidazol-4-yl}benzamide, CYS-THR-THR-LYS-ILE-LYS-PRO, ... 著者 Wei, A. 登録日 2014-07-07 公開日 2014-12-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity. J.Med.Chem., 57, 2014
4VGC	GAMMA-CHYMOTRYPSIN D-NAPHTHYL-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX 分子名称: D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION 著者 Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F. 登録日 1997-05-01 公開日 1997-11-12 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes. Biochemistry, 37, 1998
6NMB	Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator 分子名称: NITRATE ION, TRANS-4-AMINOMETHYLCYCLOHEXANE-1-CARBOXYLIC ACID, Urokinase-type plasminogen activator 著者 Law, R.H.P, Wu, G. 登録日 2019-01-10 公開日 2019-03-06 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Tranexamic acid is an active site inhibitor of urokinase plasminogen activator. Blood Adv, 3, 2019

<12345678910111213141516>