7FBP

FXIIa-cMCoFx1 complex

Summary for 7FBP

Entry DOI	10.2210/pdb7fbp/pdb
Descriptor	Coagulation factor XIIa light chain, cMCoFx1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	serine protease, inhibitor, macrocyclic peptide, cyclotide, blood clotting
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	30738.48
Authors	Sengoku, T.,Liu, W.,de Veer, S.J.,Huang, Y.H.,Okada, C.,Zdenek, C.N.,Fry, B.G.,Swedberg, J.E.,Passioura, T.,Craik, D.J.,Suga, H.,Ogata, K. (deposition date: 2021-07-12, release date: 2021-11-10, Last modification date: 2023-11-29)
Primary citation	Liu, W.,de Veer, S.J.,Huang, Y.H.,Sengoku, T.,Okada, C.,Ogata, K.,Zdenek, C.N.,Fry, B.G.,Swedberg, J.E.,Passioura, T.,Craik, D.J.,Suga, H. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human beta-Factor XIIa in a Cyclotide Scaffold. J.Am.Chem.Soc., 143:18481-18489, 2021 Cited by PubMed: 34723512 DOI: 10.1021/jacs.1c07574 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.99 Å)

Structure validation