4X1S
The crystal structure of mupain-1-16-D9A in complex with murinised human uPA at pH7.4
Summary for 4X1S
Entry DOI | 10.2210/pdb4x1s/pdb |
Related | 4N1P 4N1Q 4N1R 4X0W 4X1N |
Descriptor | mupain-1-16, Urokinase-type plasminogen activator, piperidine-1-carboximidamide, ... (4 entities in total) |
Functional Keywords | serine protease, peptidic inhibitor, upa, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P00749 |
Total number of polymer chains | 2 |
Total formula weight | 29058.16 |
Authors | Jiang, L.,Zhao, B.,Xu, P.,Andreasen, P.,Huang, M. (deposition date: 2014-11-25, release date: 2015-10-28, Last modification date: 2023-11-08) |
Primary citation | Zhao, B.,Xu, P.,Jiang, L.,Paaske, B.,Kromann-Hansen, T.,Jensen, J.K.,Srensen, H.P.,Liu, Z.,Nielsen, J.T.,Christensen, A.,Hosseini, M.,Srensen, K.K.,Nielsen, N.C.,Jensen, K.J.,Huang, M.,Andreasen, P.A. A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One, 9:e115872-e115872, 2014 Cited by PubMed: 25545505DOI: 10.1371/journal.pone.0115872 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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