PDB: 93 件ウェブページステータス検索Chemie searchBIRD

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8QKG	PvSub1 Catalytic Domain in Complex with Peptidomimetic Inhibitor (MAM-125) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Peptidomimetic Inhibitor (MAM-125), ... 著者 Batista, F.A, Martinez, M, Bouillon, A, Mechaly, A, Alzari, P.M, Haouz, A, Barale, J.C. 登録日 2023-09-15 公開日 2024-03-20 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.538 Å) 主引用文献 Insights from structure-activity relationships and the binding mode of peptidic alpha-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1. Eur.J.Med.Chem., 269, 2024
5JWB	Structure of NDH2 from plasmodium falciparum in complex with NADH 分子名称: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Yu, Y, Li, X.L. 登録日 2016-05-12 公開日 2017-03-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem., 60, 2017
5JWA	the structure of malaria PfNDH2 分子名称: ACETATE ION, FLAVIN-ADENINE DINUCLEOTIDE, FRAGMENT OF TRITON X-100, ... 著者 Yu, Y, Yang, Y.Q, Li, X.L, Yu, J, Ge, J.P, Li, J, Rao, Y, Yang, M.J. 登録日 2016-05-11 公開日 2017-03-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.162 Å) 主引用文献 Target Elucidation by Cocrystal Structures of NADH-Ubiquinone Oxidoreductase of Plasmodium falciparum (PfNDH2) with Small Molecule To Eliminate Drug-Resistant Malaria J. Med. Chem., 60, 2017
6MUV	The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators 分子名称: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... 著者 Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. 登録日 2018-10-23 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
6MUX	The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator 分子名称: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... 著者 Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. 登録日 2018-10-23 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
6MUW	The structure of the Plasmodium falciparum 20S proteasome. 分子名称: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... 著者 Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. 登録日 2018-10-23 公開日 2019-08-07 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
5FOD	Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) containing deletions of insertions 1 and 3 分子名称: 1,2-ETHANEDIOL, LEUCYL-TRNA SYNTHETASE 著者 Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. 登録日 2015-11-19 公開日 2016-06-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
5FO4	Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P1) 分子名称: LEUCYL TRNA SYNTHASE 著者 Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. 登録日 2015-11-18 公開日 2016-06-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
5FOC	Crystal structure of the P.falciparum cytosolic leucyl-tRNA synthetase editing domain (space group P21) 分子名称: LEUCYL-TRNA SYNTHETASE 著者 Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. 登録日 2015-11-19 公開日 2016-06-22 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
5FOF	Crystal structure of the P.knowlesi cytosolic leucyl-tRNA synthetase editing domain 分子名称: LEUCYL-TRNA SYNTHETASE 著者 Palencia, A, Sonoiki, E, Guo, D, Ahyong, V, Dong, C, Li, X, Hernandez, V.S, Gut, J, Legac, J, Cooper, R, Alley, M.R.K, Freund, Y.R, DeRisi, J, Cusack, S, Rosenthal, P.J. 登録日 2015-11-19 公開日 2016-06-22 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Anti-Malarial Benzoxaboroles Target P. Falciparum Leucyl-tRNA Synthetase. Antimicrob.Agents Chemother., 60, 2016
4QT2	Crystal Structure of the FK506-Binding Domain of Plasmodium Falciparum FKBP35 in complex with Rapamycin 分子名称: FK506-binding protein (FKBP)-type peptidyl-propyl isomerase, IMIDAZOLE, RAPAMYCIN IMMUNOSUPPRESSANT DRUG 著者 Bianchin, A, Allemand, F, Bell, A, Chubb, A.J, Guichou, J.-F. 登録日 2014-07-07 公開日 2015-06-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution Acta Crystallogr.,Sect.D, 71, 2015
4R7M	Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor 分子名称: 4-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, DIMETHYL SULFOXIDE, ... 著者 Drinkwater, N, Mcgowan, S. 登録日 2014-08-28 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R5V	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor 分子名称: GLYCEROL, M1 family aminopeptidase, N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}-2,2-dimethylpropanamide, ... 著者 Drinkwater, N, Mcgowan, S. 登録日 2014-08-22 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4QT3	Crystal structure resolution of Plasmodium falciparum FK506 binding domain (FKBP35) in complex with Rapamycin at 1.4A resolution 分子名称: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, FK506-binding protein (FKBP)-type peptidyl-propyl isomerase, RAPAMYCIN IMMUNOSUPPRESSANT DRUG 著者 Bianchin, A, Allemand, F, Bell, A, Chubb, A.J, Guichou, J.-F. 登録日 2014-07-07 公開日 2015-06-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Two crystal structures of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with rapamycin at high resolution Acta Crystallogr.,Sect.D, 71, 2015
4R5X	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor 分子名称: 3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, DIMETHYL SULFOXIDE, GLYCEROL, ... 著者 Drinkwater, N, Mcgowan, S. 登録日 2014-08-22 公開日 2014-10-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R76	Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor 分子名称: 3-amino-N-{(1R)-2-(hydroxyamino)-2-oxo-1-[4-(1H-pyrazol-1-yl)phenyl]ethyl}benzamide, CARBONATE ION, M17 family aminopeptidase, ... 著者 Drinkwater, N, Mcgowan, S. 登録日 2014-08-27 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R5T	Structure of the m1 alanylaminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... 著者 Drinkwater, N, Mcgowan, S. 登録日 2014-08-22 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014
4R6T	Structure of the m17 leucyl aminopeptidase from malaria complexed with a hydroxamic acid-based inhibitor 分子名称: CARBONATE ION, DIMETHYL SULFOXIDE, M17 leucyl aminopeptidase, ... 著者 Drinkwater, N, Mcgowan, S. 登録日 2014-08-26 公開日 2014-10-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors. J.Med.Chem., 57, 2014

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