PDB: 1347 件ウェブページステータス検索Chemie searchBIRD

---

6WS4	Crystal structure of KRAS-G12D/K104Q mutant, GDP-bound 分子名称: 3,3',3''-phosphanetriyltripropanoic acid, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Tran, T.H, Simanshu, D.K. 登録日 2020-04-30 公開日 2021-11-10 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Allosteric regulation of switch-II domain controls KRAS oncogenicity. Cancer Res., 2023
6X1G	Crystal structure of a GEF domain from the Orientia tsutsugamushi protein OtDUB in complex with Rac1 分子名称: MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1, ULP_PROTEASE domain-containing protein 著者 Lim, C.S, Xiong, Y. 登録日 2020-05-18 公開日 2020-11-25 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushi . Proc.Natl.Acad.Sci.USA, 117, 2020
6X2M	Crystal Structure of unliganded CRM1-Ran-RanBP1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.351 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2O	Crystal Structure of unliganded CRM1(E571K)-Ran-RanBP1 分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.551 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2P	Crystal Structure of the Mek1NES peptide bound to CRM1 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.401 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2R	Crystal Structure of the 4E-TNES peptide bound to CRM1 分子名称: Eukaryotic translation initiation factor 4E transporter, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.299 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2S	Crystal Structure of Mek1(NQ)NES peptide bound to CRM 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-20 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.496 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2U	Crystal Structure of PKINES peptide bound to CRM1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2V	Crystal Structure of PKI(DE)NES peptide bound to CRM1 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.822 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2W	Crystal Structure of PKINES peptide bound to CRM1(E571K) 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.001 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2X	Crystal Structure of Mek1NES peptide bound to CRM1(E571K) 分子名称: Dual specificity mitogen-activated protein kinase kinase 1, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.458 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6X2Y	Crystal Structure of mDia2NES peptide bound to CRM1(E571K) 分子名称: 1,2-ETHANEDIOL, Exportin-1, GLYCEROL, ... 著者 Baumhardt, J.M. 登録日 2020-05-21 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.304 Å) 主引用文献 Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
6XGU	Crystal Structure of KRAS-Q61R (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF 分子名称: GLYCEROL, GTPase KRas, MAGNESIUM ION, ... 著者 Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. 登録日 2020-06-18 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6XGV	Crystal Structure of KRAS-G13D (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF 分子名称: CHLORIDE ION, GLYCEROL, GTPase KRas, ... 著者 Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. 登録日 2020-06-18 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6XHB	Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and cysteine-rich domain (CRD) of RAF1/CRAF (crystal form II) 分子名称: CHLORIDE ION, GLYCEROL, GTPase KRas, ... 著者 Tran, T.H, Chan, A.H, Dharmaiah, S, Simanshu, D.K. 登録日 2020-06-18 公開日 2021-01-13 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation. Nat Commun, 12, 2021
6XJP	Crystal Structure of KPT-185 bound to CRM1 (537-DLTVK-541 to GLCEQ) 分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.802 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJR	Crystal Structure of KPT-185 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) 分子名称: Exportin-1, GTP-binding nuclear protein Ran, MAGNESIUM ION, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.941 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJS	Crystal Structure of KPT-330 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) 分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.942 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJT	Crystal Structure of KPT-8602 bound to CRM1 (537-DLTVK-541 to GLCEQ) 分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.406 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6XJU	Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) 分子名称: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... 著者 Baumhardt, J.M, Chook, Y.M. 登録日 2020-06-24 公開日 2021-01-27 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.193 Å) 主引用文献 Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
6Y09	Crystal structure of Atg16L in complex with GTP-bound Rab33B (Q92L) 分子名称: 1,2-ETHANEDIOL, Autophagy-related protein 16-1, DI(HYDROXYETHYL)ETHER, ... 著者 Pantoom, S, Wu, Y.W. 登録日 2020-02-07 公開日 2020-09-30 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 RAB33B recruits the ATG16L1 complex to the phagophore via a noncanonical RAB binding protein. Autophagy, 17, 2021
6Y7G	Structure of the human RAB3C in complex with GDP 分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Diaz-Saez, L, Jung, S, Raux, B, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Huber, K.V.M, Structural Genomics Consortium (SGC) 登録日 2020-02-29 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the human RAB3C in complex with GDP To Be Published
6YR8	Affimer K6 - KRAS protein complex 分子名称: Affimer K6, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. 登録日 2020-04-19 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021
6YX5	Structure of DrrA from Legionella pneumophilia in complex with human Rab8a 分子名称: MAGNESIUM ION, Multifunctional virulence effector protein DrrA, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Schneider, S, Du, J, von Wrisberg, M.K, Lang, K, Itzen, A. 登録日 2020-04-30 公開日 2020-12-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1. Nat Commun, 12, 2021
6YXW	Affimer K3 - KRAS protein complex 分子名称: Affimer K3, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. 登録日 2020-05-04 公開日 2020-07-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021

<32333435363738394041424344454647>