6YR8
Affimer K6 - KRAS protein complex
Summary for 6YR8
Entry DOI | 10.2210/pdb6yr8/pdb |
Descriptor | GTPase KRas, Affimer K6, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | protein complex, affimer, kras, inhibitor, protein binding |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 32254.57 |
Authors | Trinh, C.H.,Haza, K.Z.,Rao, A.,Martin, H.L.,Tiede, C.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C. (deposition date: 2020-04-19, release date: 2020-07-08, Last modification date: 2024-01-24) |
Primary citation | Haza, K.Z.,Martin, H.L.,Rao, A.,Turner, A.L.,Saunders, S.E.,Petersen, B.,Tiede, C.,Tipping, K.,Tang, A.A.,Ajayi, M.,Taylor, T.,Harvey, M.,Fishwick, K.M.,Adams, T.L.,Gaule, T.G.,Trinh, C.H.,Johnson, M.,Breeze, A.L.,Edwards, T.A.,McPherson, M.J.,Tomlinson, D.C. RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12:4045-4045, 2021 Cited by PubMed: 34193876DOI: 10.1038/s41467-021-24316-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report