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1GSI
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (TMP)
分子名称: ACETATE ION, MAGNESIUM ION, SULFATE ION, ...
著者Ursby, T, Weik, M, Fioravanti, E, Delarue, M, Goeldner, M, Bourgeois, D.
登録日2002-01-03
公開日2002-03-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Cryophotolysis of Caged Compounds: A Technique for Trapping Intermediate States in Protein Crystals
Acta Crystallogr.,Sect.D, 58, 2002
1GYU
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Gamma-adaptin appendage domain from clathrin adaptor AP1
分子名称: ADAPTER-RELATED PROTEIN COMPLEX 1 GAMMA 1 SUBUNIT
著者Evans, P.R, Owen, D.J, McMahon, H.M, Kent, H.M.
登録日2002-04-30
公開日2002-08-22
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Gamma-Adaptin Appendage Domain. Structure and Binding Site for Eps15 and Gamma-Synergin
Structure, 10, 2002
6OW4
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BU of 6ow4 by Molmil
Structure of the NADH-bound form of 20beta-Hydroxysteroid Dehydrogenase from Bifidobacterium adolescentis strain L2-32
分子名称: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Oxidoreductase, short chain dehydrogenase/reductase family protein
著者Mythen, S.M, Pollet, R.M, Koropatkin, N.M, Ridlon, J.M.
登録日2019-05-09
公開日2019-06-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Structural and biochemical characterization of 20 beta-hydroxysteroid dehydrogenase fromBifidobacterium adolescentisstrain L2-32.
J.Biol.Chem., 294, 2019
8C1V
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BU of 8c1v by Molmil
SARS-CoV-2 S-trimer (3 RBDs up) bound to TriSb92, fitted into cryo-EM map
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sb92, ...
著者Huiskonen, J.T, Rissanen, I, Hannula, L.
登録日2022-12-21
公開日2023-04-19
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Intranasal trimeric sherpabody inhibits SARS-CoV-2 including recent immunoevasive Omicron subvariants.
Nat Commun, 14, 2023
1HA6
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BU of 1ha6 by Molmil
NMR Solution Structure of Murine CCL20/MIP-3a Chemokine
分子名称: MACROPHAGE INFLAMMATORY PROTEIN 3 ALPHA
著者Perez-Canadillas, J.M, Zaballos, A, Gutierrez, J, Varona, R, Roncal, F, Albar, J.P, Marquez, G, Bruix, M.
登録日2001-03-28
公開日2001-08-22
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of Murine Ccl20/Mip3-A, a Chemiokine that Specifically Chemoattracs Immature Dendritic Cells and Lymphocytes Through its Highly Specific Interaction with the Beta-Chemokine Receptor Ccr6
J.Biol.Chem., 276, 2001
8CNH
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BU of 8cnh by Molmil
Crystal structure of human soluble adenylyl cyclase (sAC) in complex with inhibitor TDI-10512
分子名称: 1,2-ETHANEDIOL, ACETATE ION, Adenylate cyclase type 10, ...
著者Steegborn, C.
登録日2023-02-23
公開日2023-04-26
最終更新日2023-05-17
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J.Chem.Inf.Model., 63, 2023
8COJ
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Crystal structure of human soluble adenylyl cyclase catalytic domain in complex with the inhibitor TDI-10228
分子名称: 1,2-ETHANEDIOL, 4-chloranyl-6-[4-[(3-fluorophenyl)methyl]-1-methyl-pyrazol-3-yl]pyrimidin-2-amine, ACETATE ION, ...
著者Steegborn, C, Fushimi, M.
登録日2023-02-28
公開日2023-04-26
最終更新日2023-05-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.
J.Chem.Inf.Model., 63, 2023
3O70
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PHD-type zinc finger of human PHD finger protein 13
分子名称: GLYCEROL, PHD finger protein 13, ZINC ION
著者Lam, R, Bian, C.B, Xu, C, Kania, J, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Structural Genomics Consortium (SGC)
登録日2010-07-29
公開日2010-09-29
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献PHF13 is a molecular reader and transcriptional co-regulator of H3K4me2/3.
Elife, 5, 2016
3AB3
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Crystal structure of p115RhoGEF RGS domain in complex with G alpha 13
分子名称: GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(k) subunit alpha, Guanine nucleotide-binding protein subunit alpha-13, ...
著者Kukimoto-Niino, M, Mishima, C, Shirouzu, M, Kozasa, T, Yokoyama, S.
登録日2009-11-30
公開日2010-12-29
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Identification of critical residues in G(alpha)13 for stimulation of p115RhoGEF activity and the structure of the G(alpha)13-p115RhoGEF regulator of G protein signaling homology (RH) domain complex.
J.Biol.Chem., 286, 2011
3AGM
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Complex of PKA with the bisubstrate protein kinase inhibitor ARC-670
分子名称: N~2~-{8-OXO-8-[4-(9H-PURIN-6-YL)PIPERAZIN-1-YL]OCTANOYL}-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGINYL-D-ARGININAMIDE, cAMP-dependent protein kinase catalytic subunit alpha
著者Pflug, A, Ragozina, J, Uri, A, Bossemeyer, D, Engh, R.A.
登録日2010-04-02
公開日2010-09-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Diversity of bisubstrate binding modes of adenosine analogue-oligoarginine conjugates in protein kinase a and implications for protein substrate interactions.
J.Mol.Biol., 403, 2010
1GVL
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BU of 1gvl by Molmil
Human prokallikrein 6 (hK6)/ prozyme/ proprotease M/ proneurosin
分子名称: KALLIKREIN 6
著者Gomis-Ruth, F.X, Bayes, A, Sotiropoulou, G, Pampalakis, G, Tsetsenis, T, Villegas, V, Aviles, F.X, Coll, M.
登録日2002-02-14
公開日2002-05-16
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Structure of Human Prokallikrein 6 Reveals a Novel Activation Mechanism for the Kallikrein Family.
J.Biol.Chem., 277, 2002
8FYV
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Salmonella enterica serovar Typhimurium chemoreceptor Tsr (taxis to serine and repellents) ligand-binding domain in complex with l-serine
分子名称: CHLORIDE ION, Methyl-accepting chemotaxis protein, SERINE, ...
著者Baylink, A, Gentry-Lear, Z, Glenn, S.
登録日2023-01-26
公開日2024-05-15
最終更新日2024-06-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Bacterial vampirism mediated through taxis to serum.
Elife, 12, 2024
1H8X
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Domain-swapped Dimer of a Human Pancreatic Ribonuclease Variant
分子名称: RIBONUCLEASE 1
著者Canals, A, Pous, J, Guasch, A, Benito, A, Ribo, M, Vilanova, M, Coll, M.
登録日2001-02-16
公開日2002-02-14
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Structure of an Engineered Domain-Swapped Ribonuclease Dimer and its Implications for the Evolution of Proteins Toward Oligomerization
Structure, 9, 2001
1H3G
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BU of 1h3g by Molmil
Cyclomaltodextrinase from Flavobacterium sp. No. 92: from DNA sequence to protein structure
分子名称: CALCIUM ION, Cyclomaltodextrinase
著者Fritzsche, H.B, Schwede, T, Jelakovic, S, Schulz, G.E.
登録日2002-09-03
公開日2003-08-14
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Covalent and Three-Dimensional Structure of the Cyclodextrinase from Flavobacterium Sp. No. 92.
Eur.J.Biochem., 270, 2003
6K1J
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Human nucleosome core particle with H2A.X variant
分子名称: CHLORIDE ION, DNA (145-MER), Histone H2AX, ...
著者Sharma, D, De Falco, L, Davey, C.A.
登録日2019-05-10
公開日2020-01-15
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献PARP1 exhibits enhanced association and catalytic efficiency with gamma H2A.X-nucleosome.
Nat Commun, 10, 2019
1HAQ
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BU of 1haq by Molmil
FOUR MODELS OF HUMAN FACTOR H DETERMINED BY SOLUTION SCATTERING CURVE-FITTING AND HOMOLOGY MODELLING
分子名称: COMPLEMENT FACTOR H
著者Aslam, M, Perkins, S.J.
登録日2001-04-06
公開日2002-04-05
最終更新日2024-05-08
実験手法SOLUTION SCATTERING
主引用文献Folded-Back Solution Structure of Monomeric Factor H of Human Complement by Synchrotron X-Ray and Neutron Scattering, Analytical Ultracentrifugation and Constrained Molecular Modelling.
J.Mol.Biol., 309, 2001
1HQV
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STRUCTURE OF APOPTOSIS-LINKED PROTEIN ALG-2
分子名称: CALCIUM ION, PROGRAMMED CELL DEATH PROTEIN 6
著者Jia, J, Tarabykina, S, Hansen, C, Berchtold, M, Cygler, M.
登録日2000-12-19
公開日2001-05-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of apoptosis-linked protein ALG-2: insights into Ca2+-induced changes in penta-EF-hand proteins.
Structure, 9, 2001
1HW3
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STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS
分子名称: 1,2-ETHANEDIOL, SULFATE ION, THYMIDYLATE SYNTHASE
著者Phan, J, Steadman, J.D, Koli, S, Ding, W.C, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L.
登録日2001-01-09
公開日2001-01-24
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of human thymidylate synthase suggests advantages of chemotherapy with noncompetitive inhibitors.
J.Biol.Chem., 276, 2001
1HMF
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BU of 1hmf by Molmil
STRUCTURE OF THE HMG BOX MOTIF IN THE B-DOMAIN OF HMG1
分子名称: HIGH MOBILITY GROUP PROTEIN FRAGMENT-B
著者Weir, H.M, Kraulis, P.J, Hill, C.S, Raine, A.R.C, Laue, E.D, Thomas, J.O.
登録日1994-03-07
公開日1994-05-31
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the HMG box motif in the B-domain of HMG1.
EMBO J., 12, 1993
1HLL
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BU of 1hll by Molmil
NMR STRUCTURE OF T3-I2, A 32 RESIDUE PEPTIDE FROM THE ALPHA-2A ADRENERGIC RECEPTOR
分子名称: ALPHA-2A ADRENERGIC RECEPTOR
著者Chung, D.A, Zuiderweg, E.R.P, Neubig, R.R.
登録日2000-12-01
公開日2002-04-10
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix.
Biochemistry, 41, 2002
6HGD
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-0: a new binding globulin variant that is devoid of any cortisol-binding capabilities
分子名称: Alpha-1-antichymotrypsin
著者Gardill, B.R, Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6HGG
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-III: a new binding globulin in complex with cortisol
分子名称: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin
著者Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.787 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6HGM
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Crystal structure of Alpha1-antichymotrypsin variant NewBG-III-allo: an allosterically controlled new binding globulin with an unprecedentedly high ligand release efficacy
分子名称: 1,2-ETHANEDIOL, Alpha-1-antichymotrypsin, CALCIUM ION, ...
著者Schmidt, K, Muller, Y.A.
登録日2018-08-23
公開日2019-05-29
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.369 Å)
主引用文献NewBG: A surrogate corticosteroid-binding globulin with an unprecedentedly high ligand release efficacy.
J.Struct.Biol., 207, 2019
6HNJ
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The ligand-bound, open structure of CD0873, a substrate binding protein with adhesive properties from Clostridium difficile.
分子名称: 1,2-ETHANEDIOL, ABC-type transport system, sugar-family extracellular solute-binding protein, ...
著者Bradshaw, W.J, Kovacs-Simon, A, Harmer, N.J, Michell, S.L, Acharya, K.R.
登録日2018-09-15
公開日2019-08-28
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular features of lipoprotein CD0873: A potential vaccine against the human pathogenClostridioides difficile.
J.Biol.Chem., 294, 2019
1HVY
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Human thymidylate synthase complexed with dUMP and Raltitrexed, an antifolate drug, is in the closed conformation
分子名称: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, BETA-MERCAPTOETHANOL, THYMIDYLATE SYNTHASE, ...
著者Phan, J, Koli, S, Minor, W, Dunlap, R.B, Berger, S.H, Lebioda, L.
登録日2001-01-08
公開日2001-01-31
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug
Biochemistry, 40, 2001

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