1HQV

STRUCTURE OF APOPTOSIS-LINKED PROTEIN ALG-2

Summary for 1HQV

• Entry DOI: 10.2210/pdb1hqv/pdb
• Descriptor: PROGRAMMED CELL DEATH PROTEIN 6, CALCIUM ION (3 entities in total)
• Functional Keywords: penta-ef-hand protein, calcium binding protein, apoptosis
• Biological source: Mus musculus (house mouse)
• Cellular location: Nucleus membrane; Peripheral membrane protein (By similarity): P12815
• Total number of polymer chains: 1
• Total formula weight: 22048.71

Authors

Jia, J.,Tarabykina, S.,Hansen, C.,Berchtold, M.,Cygler, M. (deposition date: 2000-12-19, release date: 2001-05-02, Last modification date: 2024-02-07)

Primary citation

Jia, J.,Tarabykina, S.,Hansen, C.,Berchtold, M.,Cygler, M.
Structure of apoptosis-linked protein ALG-2: insights into Ca2+-induced changes in penta-EF-hand proteins.
Structure, 9:267-275, 2001

PubMed Abstract: The Ca2+ binding apoptosis-linked gene-2 (ALG-2) protein acts as a proapoptotic factor in a variety of cell lines and is required either downstream or independently of caspases for apoptosis to occur. ALG-2 belongs to the penta-EF-hand (PEF) protein family and has two high-affinity and one low-affinity Ca2+ binding sites. Like other PEF proteins, its N terminus contains a Gly/Pro-rich segment. Ca2+ binding is required for the interaction with the target protein, ALG-2 interacting protein 1 (AIP1).

PubMed: 11525164
DOI: 10.1016/S0969-2126(01)00585-8

Experimental method

X-RAY DIFFRACTION (2.3 Å)