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1HQV

STRUCTURE OF APOPTOSIS-LINKED PROTEIN ALG-2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0001525biological_processangiogenesis
A0001938biological_processpositive regulation of endothelial cell proliferation
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0006886biological_processintracellular protein transport
A0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
A0006915biological_processapoptotic process
A0010595biological_processpositive regulation of endothelial cell migration
A0012507cellular_componentER to Golgi transport vesicle membrane
A0014029biological_processneural crest formation
A0014032biological_processneural crest cell development
A0016020cellular_componentmembrane
A0030127cellular_componentCOPII vesicle coat
A0030674molecular_functionprotein-macromolecule adaptor activity
A0030948biological_processnegative regulation of vascular endothelial growth factor receptor signaling pathway
A0031410cellular_componentcytoplasmic vesicle
A0031463cellular_componentCul3-RING ubiquitin ligase complex
A0032007biological_processnegative regulation of TOR signaling
A0034605biological_processcellular response to heat
A0036324biological_processvascular endothelial growth factor receptor-2 signaling pathway
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043495molecular_functionprotein-membrane adaptor activity
A0045766biological_processpositive regulation of angiogenesis
A0046872molecular_functionmetal ion binding
A0046983molecular_functionprotein dimerization activity
A0048208biological_processCOPII vesicle coating
A0048306molecular_functioncalcium-dependent protein binding
A0051592biological_processresponse to calcium ion
A0051898biological_processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0070971cellular_componentendoplasmic reticulum exit site
A1902527biological_processpositive regulation of protein monoubiquitination
A1990756molecular_functionubiquitin-like ligase-substrate adaptor activity
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE CA A 996
ChainResidue
AASN106
AASN106
AHOH436
AHOH436
AHOH437
AHOH437
AHOH444
AHOH444

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 997
ChainResidue
AASP38
ASER40
AVAL42
AGLU47
AHOH435
AASP36

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 998
ChainResidue
AASP103
AASP105
ASER107
AMET109
AGLU114
AHOH433

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 999
ChainResidue
AASP169
AASP171
AASP173
ATRP175
AHOH432
AHOH434

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDRSGVISdnEL
ChainResidueDetails
AASP36-LEU48
AASP103-LEU115

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues9
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:11525164, ECO:0007744|PDB:1HQV
ChainResidueDetails
AASP36
AASP38
ASER40
AGLU47
AASP103
AASP105
ASER107
AMET109
AGLU114

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:11525164, ECO:0007744|PDB:1HQV
ChainResidueDetails
AVAL42

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:27541325, ECO:0007744|PDB:1HQV, ECO:0007744|PDB:5JJG
ChainResidueDetails
AASP169
AASP171
AASP173
ATRP175

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:O75340
ChainResidueDetails
AALA2

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PDB entries from 2024-07-17

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