PDB: 10970 件ウェブページステータス検索Chemie searchBIRD

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4PX6	SYK catalytic domain in complex with a potent pyridopyrimidinone inhibitor 分子名称: 7-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one, Tyrosine-protein kinase SYK 著者 Lee, C.C. 登録日 2014-03-21 公開日 2014-04-23 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Syk inhibitors with high potency in presence of blood. Bioorg.Med.Chem.Lett., 24, 2014
4HOR	Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligocytidine 分子名称: Interferon-induced protein with tetratricopeptide repeats 5, MAGNESIUM ION, RNA (5'-R(*(CTP)P*CP*CP*CP*C)-3') 著者 Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. 登録日 2012-10-22 公開日 2013-01-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.861 Å) 主引用文献 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
4QAC	X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 4-(4-methylpiperidin-1-yl)-6-(4-(trifluoromethyl)phenyl)pyrimidin-2-amine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(4-methylpiperidin-1-yl)-6-[4-(trifluoromethyl)phenyl]pyrimidin-2-amine, Acetylcholine-binding protein, ... 著者 Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P. 登録日 2014-05-03 公開日 2014-07-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc.Natl.Acad.Sci.USA, 111, 2014
6RRC	Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21 peptide 分子名称: Cohesin subunit SA-1, Double-strand-break repair protein rad21 homolog, SULFATE ION 著者 Newman, J.A, Katis, V.L, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Gileadi, O. 登録日 2019-05-17 公開日 2019-06-19 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 STAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers. Life Sci Alliance, 3, 2020
4HR3	Structure of a putative acyl-CoA dehydrogenase from Mycobacterium abscessus 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Putative acyl-CoA dehydrogenase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2012-10-26 公開日 2012-11-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
6RUM	Crystal structure of GFP-LAMA-G97 - a GFP enhancer nanobody with cpDHFR insertion and TMP and NADPH 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GFP-LAMA-G97 a GFP enhancer nanobody with cpDHFR insertion, ... 著者 Farrants, H, Tarnawski, M, Mueller, T.G, Otsuka, S, Hiblot, J, Koch, B, Kueblbeck, M, Kraeusslich, H.-G, Ellenberg, J, Johnsson, K. 登録日 2019-05-28 公開日 2020-02-12 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Chemogenetic Control of Nanobodies. Nat.Methods, 17, 2020
4HS6	Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody MRCT10.v362 分子名称: E2-peptide, MRCT10.v362 Fab heavy chain, MRCT10.v362 Fab light chain 著者 Eigenbrot, C, Ultsch, M. 登録日 2012-10-29 公開日 2013-04-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 Glycan shifting on hepatitis C virus (HCV) e2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies. J.Mol.Biol., 425, 2013
4HOU	Crystal Structure of N-terminal Human IFIT1 分子名称: Interferon-induced protein with tetratricopeptide repeats 1 著者 Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. 登録日 2012-10-22 公開日 2013-01-30 最終更新日 2013-02-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
4PYV	Crystal structure of renin in complex with compound4 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Renin, ... 著者 Ostermann, N, Zink, F. 登録日 2014-03-28 公開日 2014-10-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. ACS Med Chem Lett, 5, 2014
4Q1N	Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors 分子名称: (3S,4R,5R)-N-cyclopropyl-N'-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-N-[5-(propan-2-yl)pyridin-2-yl]piperidine-3,5-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... 著者 Schiering, N, D'Arcy, A, Irie, O, Yokokawa, F. 登録日 2014-04-04 公開日 2014-08-06 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors. ACS Med Chem Lett, 5, 2014
4MFK	The crystal structure of acyltransferase in complex with decanoyl-CoA 分子名称: Putative uncharacterized protein tcp24, SULFATE ION, decanoyl-CoA 著者 Lyu, S.Y, Liu, Y.C, Chang, C.Y, Huang, C.J, Li, T.L. 登録日 2013-08-28 公開日 2014-09-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus J.Am.Chem.Soc., 136, 2014
4Q38	The crystal structure of acyltransferase in complex with decanoyl-CoA and teicoplanin 分子名称: 2-amino-6-O-decanoyl-2-deoxy-beta-D-glucopyranose, COENZYME A, Putative uncharacterized protein tcp24, ... 著者 Li, T.-L, Lyu, S.-Y, Liu, Y.-C, Chang, C.-Y, Huang, C.-J. 登録日 2014-04-11 公開日 2014-09-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus J.Am.Chem.Soc., 136, 2014
4QAA	X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) IN COMPLEX WITH 6-(4-Methoxyphenyl)-N4-octylpyrimidine-2,4-diamine 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(4-methoxyphenyl)-N~4~-octylpyrimidine-2,4-diamine, Acetylcholine-binding protein, ... 著者 Kaczanowska, K, Harel, M, Radic, Z, Changeux, J.-P, Finn, M.G, Taylor, P. 登録日 2014-05-03 公開日 2014-07-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for cooperative interactions of substituted 2-aminopyrimidines with the acetylcholine binding protein. Proc.Natl.Acad.Sci.USA, 111, 2014
4HOT	Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligoadenine 分子名称: Interferon-induced protein with tetratricopeptide repeats 5, MAGNESIUM ION, RNA (5'-R(*(ATP)P*AP*AP*A)-3') 著者 Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. 登録日 2012-10-22 公開日 2013-01-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.501 Å) 主引用文献 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
4HON	Crystal structure of human JMJD2D/KDM4D in complex with an H3K9me3 peptide and 2-oxoglutarate 分子名称: 1,3-PROPANDIOL, 2-OXOGLUTARIC ACID, Histone H3 Peptide, ... 著者 Krishnan, S, Trievel, R.C. 登録日 2012-10-22 公開日 2012-11-21 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.799 Å) 主引用文献 Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases. Structure, 21, 2013
4HS8	Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody hu5B3.v3 分子名称: E2-peptide, GLYCEROL, SULFATE ION, ... 著者 Eigenbrot, C, Ultsch, M. 登録日 2012-10-29 公開日 2013-04-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Glycan shifting on hepatitis C virus (HCV) e2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies. J.Mol.Biol., 425, 2013
4Q25	Crystal structure of PhoU from Pseudomonas aeruginosa 分子名称: Phosphate-specific transport system accessory protein PhoU homolog 著者 Lee, S.J, Lee, B.-J, Suh, S.W. 登録日 2014-04-07 公開日 2015-02-18 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Crystal structure of PhoU from Pseudomonas aeruginosa, a negative regulator of the Pho regulon. J.Struct.Biol., 188, 2014
6IIL	USP14 catalytic domain bind to IU1-47 分子名称: 1-[1-(4-chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(piperidin-1-yl)ethan-1-one, Ubiquitin carboxyl-terminal hydrolase 14 著者 Mei, Z.Q, Wang, Y.W, Wang, F, Wang, J.W, He, W, Ding, S, Li, J.W. 登録日 2018-10-07 公開日 2018-12-12 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res., 28, 2018
2YAS	HYDROXYNITRILE LYASE FROM HEVEA BRASILIENSIS COMPLEXED WITH RHODANIDE 分子名称: PROTEIN (HYDROXYNITRILE LYASE), SULFATE ION, THIOCYANATE ION 著者 Gruber, K, Gugganig, M, Kratky, C. 登録日 1999-03-11 公開日 1999-10-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis. Protein Sci., 8, 1999
4HOS	Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligouridine 分子名称: Interferon-induced protein with tetratricopeptide repeats 5, RNA (5'-R(*(UTP)P*UP*UP*U)-3'), SODIUM ION 著者 Abbas, Y.M, Pichlmair, A, Gorna, M.W, Superti-Furga, G, Nagar, B. 登録日 2012-10-22 公開日 2013-01-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins. Nature, 494, 2013
4Q49	Room temperature neutron crystal structure of apo human carbonic anhydrase at pH 7.5 分子名称: Carbonic anhydrase 2, ZINC ION 著者 Fisher, S.Z, McKenna, R. 登録日 2014-04-14 公開日 2015-02-25 最終更新日 2023-09-20 実験手法 NEUTRON DIFFRACTION (1.8 Å) 主引用文献 Joint neutron crystallographic and NMR solution studies of Tyr residue ionization and hydrogen bonding: Implications for enzyme-mediated proton transfer. Proc.Natl.Acad.Sci.USA, 112, 2015
3TED	Crystal structure of the Chd1 DNA-binding domain in complex with a DNA duplex 分子名称: 5'-D(*CP*CP*AP*TP*AP*TP*AP*TP*AP*TP*GP*C)-3', 5'-D(*GP*CP*AP*TP*AP*TP*AP*TP*AP*TP*GP*G)-3', Chromo domain-containing protein 1 著者 Sharma, A, Jenkins, K.R, Heroux, A, Bowman, G.D. 登録日 2011-08-12 公開日 2011-11-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 DNA-binding domain of Chd1 in complex with a DNA duplex J.Biol.Chem., 2011
4Q36	The crystal structure of acyltransferase in complex with octanoyl-CoA and teicoplanin 分子名称: 2-amino-2-deoxy-beta-D-glucopyranose, OCTANOYL-COENZYME A, Putative uncharacterized protein tcp24, ... 著者 Li, T.-L, Lyu, S.-Y, Liu, Y.-C, Chang, C.-Y, Huang, C.-J. 登録日 2014-04-11 公開日 2014-09-10 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Multiple complexes of long aliphatic N-acyltransferases lead to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics, effectively killing vancomycin-resistant enterococcus J.Am.Chem.Soc., 136, 2014
6SCO	Cryo-EM Structure of Potato Leaf Roll Virus VLP 分子名称: Coat protein 著者 Byrne, M.J, Ranson, N.A. 登録日 2019-07-25 公開日 2019-10-02 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Combining Transient Expression and Cryo-EM to Obtain High-Resolution Structures of Luteovirid Particles. Structure, 27, 2019
6SGK	Nek2 kinase bound to inhibitor 102 分子名称: 2-phenylazanyl-9~{H}-purine-6-carbonitrile, Serine/threonine-protein kinase Nek2 著者 Richards, M.W, Mas-Droux, C.P, Bayliss, R. 登録日 2019-08-05 公開日 2020-06-17 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. Rsc Med Chem, 11, 2020

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