4HS8

Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody hu5B3.v3

Summary for 4HS8

• Entry DOI: 10.2210/pdb4hs8/pdb
• Related: 4HS6
• Descriptor: E2-peptide, antibody hu5B3.v2 Fab heavy chain, antibody hu5B3.v2 Fab light chain, ... (6 entities in total)
• Functional Keywords: immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 50617.04

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2012-10-29, release date: 2013-04-03, Last modification date: 2023-09-20)

• Primary citation: Pantua, H.,Diao, J.,Ultsch, M.,Hazen, M.,Mathieu, M.,McCutcheon, K.,Takeda, K.,Date, S.,Cheung, T.K.,Phung, Q.,Hass, P.,Arnott, D.,Hongo, J.A.,Matthews, D.J.,Brown, A.,Patel, A.H.,Kelley, R.F.,Eigenbrot, C.,Kapadia, S.B.; Glycan shifting on hepatitis C virus (HCV) e2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies.; J.Mol.Biol., 425:1899-1914, 2013; PubMed: 23458406; DOI: 10.1016/j.jmb.2013.02.025

Experimental method

X-RAY DIFFRACTION (2.6 Å)