4HS6
Hepatitus C envelope glycoprotein E2 fragment 412-423 with humanized and affinity-matured antibody MRCT10.v362
Summary for 4HS6
Entry DOI | 10.2210/pdb4hs6/pdb |
Related | 4HS8 |
Descriptor | E2-peptide, MRCT10.v362 Fab light chain, MRCT10.v362 Fab heavy chain, ... (4 entities in total) |
Functional Keywords | immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 99520.57 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2012-10-29, release date: 2013-04-03, Last modification date: 2023-09-20) |
Primary citation | Pantua, H.,Diao, J.,Ultsch, M.,Hazen, M.,Mathieu, M.,McCutcheon, K.,Takeda, K.,Date, S.,Cheung, T.K.,Phung, Q.,Hass, P.,Arnott, D.,Hongo, J.A.,Matthews, D.J.,Brown, A.,Patel, A.H.,Kelley, R.F.,Eigenbrot, C.,Kapadia, S.B. Glycan shifting on hepatitis C virus (HCV) e2 glycoprotein is a mechanism for escape from broadly neutralizing antibodies. J.Mol.Biol., 425:1899-1914, 2013 Cited by PubMed: 23458406DOI: 10.1016/j.jmb.2013.02.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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