4HOT

Crystal Structure of Full-Length Human IFIT5 with 5`-triphosphate Oligoadenine

Summary for 4HOT

• Entry DOI: 10.2210/pdb4hot/pdb
• Related: 4HOQ 4HOR 4HOS 4HOU
• Descriptor: Interferon-induced protein with tetratricopeptide repeats 5, RNA (5'-R(*(ATP)P*AP*AP*A)-3'), MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: tpr, rna binding, antiviral, rna, rna binding protein-rna complex, rna binding protein/rna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 57389.85

Authors

Abbas, Y.M.,Pichlmair, A.,Gorna, M.W.,Superti-Furga, G.,Nagar, B. (deposition date: 2012-10-22, release date: 2013-01-23, Last modification date: 2024-02-28)

• Primary citation: Abbas, Y.M.,Pichlmair, A.,Gorna, M.W.,Superti-Furga, G.,Nagar, B.; Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.; Nature, 494:60-64, 2013; PubMed: 23334420; DOI: 10.1038/nature11783

Experimental method

X-RAY DIFFRACTION (2.501 Å)