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4PX6

SYK catalytic domain in complex with a potent pyridopyrimidinone inhibitor

Summary for 4PX6
Entry DOI10.2210/pdb4px6/pdb
DescriptorTyrosine-protein kinase SYK, 7-{[(1R,2S)-2-aminocyclohexyl]amino}-5-(1H-indol-7-ylamino)pyrido[4,3-d]pyrimidin-4(3H)-one (3 entities in total)
Functional Keywordskinase domain, phosphotransferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCell membrane (Probable): P43405
Total number of polymer chains1
Total formula weight34245.38
Authors
Lee, C.C. (deposition date: 2014-03-21, release date: 2014-04-23, Last modification date: 2023-09-20)
Primary citationThoma, G.,Blanz, J.,Buhlmayer, P.,Druckes, P.,Kittelmann, M.,Smith, A.B.,van Eis, M.,Vangrevelinghe, E.,Zerwes, H.G.,Che, J.J.,He, X.,Jin, Y.,Lee, C.C.,Michellys, P.Y.,Uno, T.,Liu, H.
Syk inhibitors with high potency in presence of blood.
Bioorg.Med.Chem.Lett., 24:2278-2282, 2014
Cited by
PubMed: 24726806
DOI: 10.1016/j.bmcl.2014.03.075
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

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