PDB: 48062 件ウェブページステータス検索Chemie searchBIRD

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3S2R	ATChloroNEET (H87C mutant) 分子名称: AT5g51720/MIO24_14, FE2/S2 (INORGANIC) CLUSTER 著者 livnah, O, Eisenberg-Domovich, Y, nechushtai, R. 登録日 2011-05-17 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.14 Å) 主引用文献 Arabidopsis thaliana ChloroNEET, a Member of the New NEET Family of Human Proteins, is Involved in Development, Senescence and Iron Metabolism. To be Published
6SBS	YtrA from Sulfolobus acidocaldarius, a GntR-family transcription factor 分子名称: Regulatory protein 著者 Lemmens, L, Valegard, K, Lindas, A.C, Peeters, E, Maes, D. 登録日 2019-07-22 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.801 Å) 主引用文献 YtrASa, a GntR-Family Transcription Factor, Represses Two Genetic Loci Encoding Membrane Proteins inSulfolobus acidocaldarius. Front Microbiol, 10, 2019
3SAO	The Siderocalin Ex-FABP functions through dual ligand specificities 分子名称: (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, 2,3-DIHYDROXY-BENZOIC ACID, Extracellular fatty acid-binding protein, ... 著者 Correnti, C, Strong, R.K, Clifton, M.C. 登録日 2011-06-03 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Galline Ex-FABP Is an Antibacterial Siderocalin and a Lysophosphatidic Acid Sensor Functioning through Dual Ligand Specificities. Structure, 19, 2011
6SN1	Crystal structure of the human INTS13-INTS14 complex 分子名称: Integrator complex subunit 13, Integrator complex subunit 14, SULFATE ION 著者 Jonas, S, Sabath, K, Staeubli, M.L. 登録日 2019-08-23 公開日 2020-07-22 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module. Nat Commun, 11, 2020
6SLE	Structure of Reductive Aminase from Neosartorya fumigata in complex with NADP+ 分子名称: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxidoreductase, putative 著者 Sharma, M, Mangas-Sanchez, J, Turner, N.J, Grogan, G. 登録日 2019-08-19 公開日 2020-06-24 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.77 Å) 主引用文献 Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases. Chem Sci, 11, 2020
6SPT	High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity 分子名称: 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... 著者 Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G. 登録日 2019-09-02 公開日 2020-01-01 最終更新日 2020-02-05 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity. J.Med.Chem., 63, 2020
3STA	Crystal structure of ClpP in tetradecameric form from Staphylococcus aureus 分子名称: ATP-dependent Clp protease proteolytic subunit 著者 Zhang, J, Ye, F, Lan, L, Jiang, H, Luo, C, Yang, C.-G. 登録日 2011-07-09 公開日 2011-09-07 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Structural switching of Staphylococcus aureus Clp protease: a key to understanding protease dynamics J.Biol.Chem., 286, 2011
3T4W	The crystal structure of mandelate racemase/muconate lactonizing enzyme from Sulfitobacter sp 分子名称: Mandelate racemase/muconate lactonizing enzyme family protein 著者 Zhang, Z, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2011-07-26 公開日 2011-08-17 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.522 Å) 主引用文献 The crystal structure of mandelate racemase/muconate lactonizing enzyme from Sulfitobacter sp To be Published
8R1X	Solution structure and chemical shift assignments for HMG-D Y12F mutant complexed to a 14:12 dA2 bulge DNA 分子名称: DNA (5'-D(*CP*GP*AP*TP*AP*TP*TP*AP*AP*GP*AP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*TP*CP*AP*AP*TP*AP*TP*CP*G)-3'), High mobility group protein D 著者 Yang, J.C, Hill, G.R, Neuhaus, D. 登録日 2023-11-02 公開日 2024-09-11 実験手法 SOLUTION NMR 主引用文献 A Single Interfacial Point Mutation Rescues Solution Structure Determination of the Complex of HMG-D with a DNA Bulge. Chembiochem, 2024
6T0O	Crystal structure of YTHDC1 with fragment 14 (ACA_DC1_004) 分子名称: 2-methyl-3~{H}-pyrido[3,4-d]pyrimidin-4-one, SULFATE ION, YTHDC1 著者 Bedi, R.K, Huang, D, Sledz, P, Caflisch, A. 登録日 2019-10-03 公開日 2020-03-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments. Acs Chem.Biol., 15, 2020
6ST3	HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide 分子名称: 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, Egl nine homolog 1, FORMIC ACID, ... 著者 Chowdhury, R, Holt-Martyn, J.P, Schofield, C.J. 登録日 2019-09-10 公開日 2019-12-04 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.426 Å) 主引用文献 Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem, 15, 2020
3RQO	Structure of the endothelial nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-((1S,2R/1R,2S)-2-(3-Clorophenyl)cyclopropylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-chlorophenyl)cyclopropyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... 著者 Li, H, Delker, S.L, Poulos, T.L. 登録日 2011-04-28 公開日 2012-05-02 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase. Bioorg.Med.Chem., 21, 2013
3R8C	Crystal structure of cytidylate kinase (Cmk) from Mycobacterium abscessus 分子名称: Cytidylate kinase 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2011-03-23 公開日 2011-03-30 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Increasing the structural coverage of tuberculosis drug targets. Tuberculosis (Edinb), 95, 2015
3RM8	AMCase in complex with Compound 2 分子名称: 2-methyl-3-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1H-indole, Acidic mammalian chitinase 著者 Olland, A. 登録日 2011-04-20 公開日 2011-08-24 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification and Characterization of Acidic Mammalian Chitinase Inhibitors J.Med.Chem., 53, 2010
6RFZ	Photorhabdus laumondii lectin PLL2 in complex with D-glucose 分子名称: 1,2-ETHANEDIOL, ACETATE ION, SODIUM ION, ... 著者 Houser, J, Fujdiarova, E, Wimmerova, M. 登録日 2019-04-16 公開日 2020-07-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Heptabladed beta-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system. Febs J., 288, 2021
6RG1	Photorhabdus laumondii lectin PLL2 in complex with L-rhamnose 分子名称: 1,2-ETHANEDIOL, ACETATE ION, SODIUM ION, ... 著者 Houser, J, Fujdiarova, E, Wimmerova, M. 登録日 2019-04-16 公開日 2020-07-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Heptabladed beta-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system. Febs J., 288, 2021
6RG2	Photorhabdus laumondii lectin PLL2 in complex with 3-O-methyl-D-glucose 分子名称: 3-O-methyl-alpha-D-glucopyranose, 3-O-methyl-beta-D-glucopyranose, ACETATE ION, ... 著者 Houser, J, Fujdiarova, E, Wimmerova, M. 登録日 2019-04-16 公開日 2020-07-01 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 Heptabladed beta-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system. Febs J., 288, 2021
6RN5	PptA from Streptomyces chartreusis 分子名称: CARBONATE ION, CHAD domain protein, CHLORIDE ION, ... 著者 Werten, S, Rustmeier, N.H, Hinrichs, W. 登録日 2019-05-08 公開日 2019-06-19 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.037 Å) 主引用文献 Structural and biochemical analysis of a phosin from Streptomyces chartreusis reveals a combined polyphosphate- and metal-binding fold. Febs Lett., 593, 2019
3RZ6	Neutron structure of perdeuterated rubredoxin using 40 hours 1st pass data 分子名称: FE (III) ION, Rubredoxin 著者 Munshi, P, Chung, C.-L, Weiss, K.L, Blakeley, M.P, Myles, D.A.A, Meilleur, F. 登録日 2011-05-11 公開日 2011-12-28 最終更新日 2023-09-13 実験手法 NEUTRON DIFFRACTION (1.75 Å) 主引用文献 Rapid visualization of hydrogen positions in protein neutron crystallographic structures. Acta Crystallogr.,Sect.D, 68, 2012
6S52	The crystal structure of glycogen phosphorylase in complex with 14 分子名称: (2~{R},3~{S},4~{S},5~{R},6~{R})-2-(hydroxymethyl)-6-(5-phenyl-1,2,3,4-tetrazol-2-yl)oxane-3,4,5-triol, Glycogen phosphorylase, muscle form, ... 著者 Kyriakis, E, Solovou, T.G.A, Papaioannou, O.S.E, Skamnaki, V.T, Leonidas, D.D. 登録日 2019-06-29 公開日 2020-02-19 実験手法 X-RAY DIFFRACTION (2.37 Å) 主引用文献 The architecture of hydrogen and sulfur sigma-hole interactions explain differences in the inhibitory potency of C-beta-d-glucopyranosyl thiazoles, imidazoles and an N-beta-d glucopyranosyl tetrazole for human liver glycogen phosphorylase and offer new insights to structure-based design. Bioorg.Med.Chem., 28, 2020
3SM4	Crystal Structure of the K131A Mutant of Lambda Exonuclease in Complex with a 5'-Phosphorylated 14-mer/12-mer Duplex and Magnesium 分子名称: 5'-D(*TP*CP*GP*GP*TP*AP*CP*AP*GP*TP*AP*G)-3', 5'-D(P*AP*GP*CP*TP*AP*CP*TP*GP*TP*AP*CP*CP*GP*A)-3', CHLORIDE ION, ... 著者 Bell, C.E, Zhang, J. 登録日 2011-06-27 公開日 2011-07-20 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity. Proc.Natl.Acad.Sci.USA, 108, 2011
8S9H	Crystal structure of monkey TLR7 ectodomain with compound 14 分子名称: (3S)-3-{[5-amino-1-({3-methoxy-5-[1-(oxan-4-yl)piperidin-4-yl]pyridin-2-yl}methyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl]amino}hexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Critton, D.A. 登録日 2023-03-28 公開日 2024-02-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.437 Å) 主引用文献 Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology. Acs Med.Chem.Lett., 15, 2024
6QL7	Structure of fatty acid synthase complex with bound gamma subunit from Saccharomyces cerevisiae at 4.6 angstrom 分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, Translation machinery-associated protein 17 著者 Singh, K, Graf, B, Linden, A, Sautner, V, Urlaub, H, Tittmann, K, Stark, H, Chari, A. 登録日 2019-01-31 公開日 2020-03-18 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (4.6 Å) 主引用文献 Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase. Cell, 180, 2020
6PTD	PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C MUTANT H32L 分子名称: PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C 著者 Heinz, D.W. 登録日 1997-07-18 公開日 1998-01-21 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry, 36, 1997
8R5U	VIM-2 metallo-beta-lactamase in complex with benzebisheterocycle compound 14 分子名称: Beta-lactamase VIM-2, FORMIC ACID, ZINC ION, ... 著者 Hinchliffe, P, Spencer, J. 登録日 2023-11-17 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Rational Design of Benzobisheterocycle Metallo-beta-Lactamase Inhibitors: A Tricyclic Scaffold Enhances Potency against Target Enzymes. J.Med.Chem., 67, 2024

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