8S9H

Crystal structure of monkey TLR7 ectodomain with compound 14

Summary for 8S9H

• Entry DOI: 10.2210/pdb8s9h/pdb
• Descriptor: Toll-like receptor 7, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: toll-like receptor 7, pattern recognition receptor, immune system, agonist
• Biological source: Macaca mulatta (Rhesus monkey)
• Total number of polymer chains: 2
• Total formula weight: 194255.46

Authors

Critton, D.A. (deposition date: 2023-03-28, release date: 2024-02-07, Last modification date: 2024-02-28)

• Primary citation: He, L.,Zhang, M.Y.,Cox, M.,Zhang, Q.,Donnell, A.F.,Zhang, Y.,Tarby, C.,Gill, P.,Subbaiah, M.A.M.,Ramar, T.,Reddy, M.,Puttapaka, V.,Li, Y.X.,Sivaprakasam, P.,Critton, D.,Mulligan, D.,Xie, C.,Ramakrishnan, R.,Nagar, J.,Dudhgaonkar, S.,Murtaza, A.,Oderinde, M.S.,Schieven, G.L.,Mathur, A.,Gavai, A.V.,Vite, G.,Gangwar, S.,Poudel, Y.B.; Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.; Acs Med.Chem.Lett., 15:189-196, 2024; PubMed: 38352849; DOI: 10.1021/acsmedchemlett.3c00456

Experimental method

X-RAY DIFFRACTION (2.437 Å)