8S9H
Crystal structure of monkey TLR7 ectodomain with compound 14
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Toll-like receptor 7 | polymer | 817 | 94014.7 | 2 | UniProt (G8E2R2) Pfam (PF13855) UniProt (by SIFTS) (B3Y653) In PDB | Macaca mulatta (Rhesus monkey) | |
2 | C | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
3 | D, E, F | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
4 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 14 | Chemie (NAG) | |||
5 | A, B | (3S)-3-{[5-amino-1-({3-methoxy-5-[1-(oxan-4-yl)piperidin-4-yl]pyridin-2-yl}methyl)-1H-pyrazolo[4,3-d]pyrimidin-7-yl]amino}hexan-1-ol | non-polymer | 538.7 | 2 | Chemie (ZWV) | |||
6 | A, B | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
7 | water | water | 18.0 | 711 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 839 (UniProt: G8E2R2)
PDB | External Database | Details |
---|---|---|
Arg 23 | - | expression tag |
Ser 24 | - | expression tag |
Pro 25 | - | expression tag |
Trp 26 | - | expression tag |
Gln 167 | Asn 166 | conflict |
Gln 389 | Asn 388 | conflict |
Gln 488 | Asn 487 | conflict |
Gln 799 | Asn 798 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 188029.3 | |
Branched | Number of molecules | 4 |
Total formula weight | 1859.7 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 4366.4 | |
All* | Total formula weight | 194255.5 |