3RM8

AMCase in complex with Compound 2

Summary for 3RM8

Entry DOI	10.2210/pdb3rm8/pdb
Related	3RM4 3RM9 3RME
Descriptor	Acidic mammalian chitinase, 2-methyl-3-{[4-(pyridin-2-yl)piperazin-1-yl]methyl}-1H-indole (3 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: Q9BZP6
Total number of polymer chains	2
Total formula weight	89019.55
Authors	Olland, A. (deposition date: 2011-04-20, release date: 2011-08-24, Last modification date: 2023-09-13)
Primary citation	Cole, D.C.,Olland, A.M.,Jacob, J.,Brooks, J.,Bursavich, M.G.,Czerwinski, R.,Declercq, C.,Johnson, M.,Joseph-McCarthy, D.,Ellingboe, J.W.,Lin, L.,Nowak, P.,Presman, E.,Strand, J.,Tam, A.,Williams, C.M.M.,Yao, S.,Tsao, D.H.H.,Fitz, L.J. Identification and Characterization of Acidic Mammalian Chitinase Inhibitors J.Med.Chem., 53:6122-6128, 2010 Cited by PubMed: 20666458 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation